- Basic information
- CohesinDB ID: CDBP00415381
- Locus: chr21-26022497-26023913
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Data sourse: ENCSR000BLD, ENCSR000BTQ, GSE206145-GSE177045, GSE67783, GSE72082, GSE76893, GSE105028, ENCSR703TNG, GSE25021
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Cell type: MCF-7, H1-hESC, HSPC, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 8% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: Mau2,SA1,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: False
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 62%,
"4_Tx": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, PGR, FOXA2, PAF1, SIN3A, ZFX, SOX2, SMAD3, FOXA1, CDK9, TFAP4, HNRNPK, ZBTB7B, RUNX2, MYC, ZFP64, RFX1, GR, PRDM1, ARNT, HIF1A, PBX4, GRHL3, OTX2, GATA3, PRDM9, ZNF10, ZNF143, MED1, TLE3, NR3C1, ESRRA, CEBPB, TEAD1, NR2F2, CREB1, TCF7L2, SNAI2, ESR1, GRHL2, CTCF, RBM22, TCF12, EP300, USF1, AR, KLF17, HDAC2, REST, PRDM4, IRF4, EGLN2, POU2F3, BRD4, SMARCA5, E2F1, TEAD4, TFAP2C
- Target gene symbol (double-evidenced CRMs): APP,MRPL39
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 128
- Number of somatic mutations (non-coding): 0
- Related genes and loops