- Basic information
- CohesinDB ID: CDBP00415411
- Locus: chr21-26115274-26117937
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BLY, GSE25021, GSE165895, GSE115602, ENCSR000BTU, GSE138405, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, ENCSR000EHW, GSE206145, ENCSR000EHX, ENCSR000BTQ, GSE111913, GSE83726, GSE126990, GSE50893
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Cell type: MCF-7, H1-hESC, Fibroblast, Hela-Kyoto, RH4, HEK293T, SNYDER, Ishikawa, SK-N-SH, RT-112, Liver, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 11% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.867
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 45%,
"7_Enh": 39%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, SOX2, XBP1, FOXA1, ATF3, NFIC, CHD7, PRDM1, ZBTB44, IKZF3, WDHD1, RUNX3, SMARCE1, PAX5, ZNF629, TEAD1, ELF1, KLF10, ZNF217, ESR1, PITX3, JUN, TCF12, CTCF, EP300, BAF155, ZNF157, GATA6, SOX9, DPF2, SOX4, IRF4, ZNF528, TEAD4, PDX1, RBPJ, TFAP2C, NANOG, CHD8, POU5F1, MYCN, CTBP1, ZNF317, ZBTB17, SRF, SP4, ERG, ASCL1, MYC, SMARCA4, RFX1, RAD21, GRHL3, PROX1, NKX2-1, RXRA, GABPA, STAT3, UBN1, NKX3-1, RCOR1, VDR, ARNTL, NR3C1, ESRRA, ZNF750, CEBPB, GRHL2, ZNF652, EBF3, TRPS1, MRTFA, SPI1, HDAC2, GATA2, FLI1, MXI1, MRTFB, ZIM3, RUNX1, CBX1, SMC1A, ZBTB24, NKX2-2, SIN3A, ZNF534, AFF4, SMAD3, ZNF770, TWIST1, SMARCC1, ZXDC, ZNF35, NOTCH1, CREBBP, RUNX2, SMAD2, GATA4, OSR2, ZNF184, GR, ARNT, NFIB, PBX4, NRF1, ATF2, ZEB2, FOXM1, PBX3, MAFB, CDK8, MED1, ZEB1, MYB, PIAS1, STAT5A, RBM22, SP1, NIPBL, BCL11A, REST, POU2F3, ATF7, ASH2L, CTBP2, PHIP, MBD2, FOXP1, PRDM6, ZNF34, PAX7, PPARG, FOXA2, MTA3, RBBP5, CHD2, PAF1, SS18, ZNF600, ZSCAN16, EBF1, WT1, FOXF1, ZNF574, HOXB13, KDM1A, RELA, TARDBP, NEUROD1, JUNB, ISL1, TCF4, HIF1A, OTX2, GATA3, BATF, TAL1, MAX, NRIP1, SPIB, HAND2, TLE3, KLF4, NR2F2, TCF7L2, KDM5B, TP53, ZBTB6, ZNF334, MYOD1, PHOX2B, ELF3, BRD2, TBX21, AR, YAP1, EGLN2, ZNF366, ZBTB26, NOTCH3, BRD4, JUND, TBX2, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): APP
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 120
- Number of somatic mutations (non-coding): 9
- Related genes and loops