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Basic information

CohesinDB ID: CDBP00415423

Locus: chr21-26150217-26150652

Data sourse: ENCSR000BLD, GSE138405, ENCSR000BLY, GSE105028, ENCSR000ECE, GSE120943, GSE25021

Cell type: MCF-7, H1-hESC, Hela-Kyoto, Monocytes, SK-N-SH, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 68% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 63%, "7_Enh": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXA2, POU5F1, MAFF, WT1, ZBTB48, FOXA1, FOXF1, SRF, DDX5, ZNF28, ZBTB2, ZNF384, OGG1, NEUROD1, SMARCA4, CHD7, RAD21, ARNT, HIF1A, RXRA, OTX2, GATA3, ZNF189, MZF1, GATA1, VDR, CCAR2, SMAD1, ESR1, SETDB1, CTCF, ELF3, MAFK, RBM22, SP1, HNF4A, AR, GATA6, ZNF211, PHIP, CLOCK

Target gene symbol (double-evidenced CRMs): APP,GABPA,ADAMTS1,MRPL39,JAM2,CYYR1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 14

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000154719, ENSG00000154721, ENSG00000154727, ENSG00000142192, ENSG00000166265, ENSG00000154734,

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Deatailed information for cohesin site CDBP00415423