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Basic information

CohesinDB ID: CDBP00415425

Locus: chr21-26153595-26154542

Data sourse: GSE206145-GSE177045, GSE104888, GSE138405, GSE206145, GSE206145-NatGen2015, GSE165895

Cell type: MCF-7, RPE, Hela-Kyoto, Fibroblast, HCT-116, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: NIPBL,SA1,SMC1,SA2,Mau2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 68% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 55%, "7_Enh": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, FOXA2, NME2, FOXA1, SMARCC1, HOXC5, RELA, RUNX2, GATA4, PBX4, HIF1A, ARNT, NKX2-1, GATA3, PBX3, MAX, MED1, NR3C1, ESRRA, CEBPB, TEAD1, TCF7L2, PIAS1, TP53, TCF12, MAFK, SP1, NIPBL, EP300, AR, GATA2, FLI1, BRD4, JUND, PRDM6, PDX1, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): APP,CYYR1,MRPL39,GABPA,ADAMTS1,JAM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 21

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000154719, ENSG00000154721, ENSG00000154727, ENSG00000142192, ENSG00000166265, ENSG00000154734,

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Deatailed information for cohesin site CDBP00415425