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Basic information

CohesinDB ID: CDBP00415427

Locus: chr21-26158881-26159268

Data sourse: ENCSR703TNG, GSE206145-NatGen2015, GSE72082

Cell type: MCF-7, Fibroblast

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SA1,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 68% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 49%, "7_Enh": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, PGR, BCL6, PPARG, CBX1, BRD3, ZSCAN5C, POU5F1, PAF1, SOX13, XBP1, GTF2B, ZBTB17, FOXA3, ZBTB48, FOXA1, SMAD3, MLLT3, SAP130, ZNF580, HOXB13, TCOF1, ERG, RARA, NR2F2, NR3C1, RUNX2, MYC, GATA4, RAD21, HIF1A, GATA3, SMAD4, GABPA, STAT3, MAX, NRIP1, GATA1, NKX3-1, HAND2, CEBPG, ESRRA, KLF4, TEAD3, TERF1, TEAD1, TRIM28, NCOA3, TCF7L2, KLF5, EZH2, ZNF217, TP53, ESR1, NR1H2, GRHL2, TBX5, ELF3, BRD2, SPI1, BAF155, ZNF664, HNF4A, AR, SOX5, GATA6, HDAC2, GATA2, FLI1, ASH2L, BRD4, PHIP, FOXP1, MAZ, NFIL3, TEAD4, ZNF554, ZNF24, TFAP2C

Target gene symbol (double-evidenced CRMs): GABPA,CYYR1,MRPL39,ADAMTS1,APP,JAM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 28

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000154719, ENSG00000154721, ENSG00000154727, ENSG00000142192, ENSG00000166265, ENSG00000154734,

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Deatailed information for cohesin site CDBP00415427