- Basic information
- CohesinDB ID: CDBP00415484
- Locus: chr21-26405129-26407108
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Data sourse: ENCSR230ZWH, GSE165895, GSE111913, GSE206145, GSE85526, ENCSR000ECE, GSE206145-NatGen2015, ENCSR000EDE, GSE68388, GSE83726, GSE116344, ENCSR000ECS, ENCSR917QNE
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Cell type: RPE, H1-hESC, Fibroblast, RH4, HEKn, HeLa-S3, RT-112, Liver, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 8% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.889
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
54% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 49%,
"7_Enh": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, PGR, SMARCA2, E2F7, XBP1, FOXA1, MLL4, ZFHX2, ATF3, ZFP64, RUNX3, TP63, MITF, BACH2, MAF, TEAD1, TRIM28, BCLAF1, KLF6, ELF1, NFE2L2, ETV1, ESR1, MLL, MED26, OCA2, HNF1B, JUN, TCF12, CTCF, EP300, IRF4, E2F1, TEAD4, KMT2B, RBPJ, TFAP2C, POU2F2, CHD8, BRD1, ZNF263, MYCN, POU5F1, KDM4C, TOP2A, ZNF317, ZBTB17, ZBTB48, ZSCAN5A, STAT1, SRF, ERG2, HOXC5, ERG, ETS1, MYC, SMARCA4, RAD21, PROX1, NKX2-1, GABPA, STAT3, NFE2, RCOR1, ARNTL, ZNF750, CEBPB, KMT2A, EZH2, EBF3, NFE2L1, ZHX2, IRF1, FLI1, MRTFB, MYF5, RUNX1, MAFG, BCL6, SMC1A, CEBPA, ZFX, SMAD3, ERG3, SMARCC1, RUNX2, CDK6, NRF1, BACH1, PRDM9, FOS, CDK8, MED1, ZEB1, SPDEF, TERF1, PIAS1, KLF9, C11orf30, MAFK, BCL11A, GSPT2, PHIP, PPARG, TBL1X, FOXA2, EBF1, MEIS1, GTF2B, MAFF, KDM1A, RELA, JUNB, AHR, HIF1A, OTX2, MAX, ZNF143, KLF4, KDM5B, TP53, MED, NFKB1, MYOD1, EGR2, PHOX2B, ELF3, BRD2, PAX3-FOXO1, AR, EGLN2, NOTCH3, BRD4, JUND, TBX2, ZNF316, FOSL2
- Target gene symbol (double-evidenced CRMs): APP,GABPA
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 5
- Related genes and loops