Deatailed information for gene ENSG00000141959
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00008178
- Gene Symbol: PFKL
- Ensembl ID: ENSG00000141959
-
Gene locus: chr21:44300050-44327376
Strand: +
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-42524067-42525788,
chr21-42526135-42528623,
chr21-42528891-42529866,
chr21-42530287-42531423,
chr21-42532164-42534148,
chr21-42534381-42538581,
chr21-42538854-42540670,
chr21-42540899-42541525,
chr21-42542597-42549588,
chr21-42971699-42976556,
chr21-42977567-42978245,
chr21-42978524-42979165,
chr21-42979449-42979775,
chr21-42980073-42980693,
chr21-42981060-42983699,
chr21-42984049-42984123,
chr21-42984399-42985953,
chr21-42986206-42987380,
chr21-42987592-42989052,
chr21-42989441-42990324,
chr21-42991464-42993497,
chr21-42993747-42994516,
chr21-42996864-42997865,
chr21-42998695-42999369,
chr21-43167531-43179410,
chr21-43179782-43180289,
chr21-43180997-43181922,
chr21-43186619-43189146,
chr21-43189488-43189736,
chr21-43190641-43195980,
chr21-43196363-43198075,
chr21-43265406-43280154,
chr21-43280924-43283710,
chr21-43285633-43286421,
chr21-43287064-43289808,
chr21-43290025-43293553,
chr21-43294387-43294818,
chr21-43295496-43295735,
chr21-43296982-43309547,
chr21-43311036-43327583,
chr21-43328508-43351938,
chr21-43352261-43357227,
chr21-43357471-43370764,
chr21-43371758-43372139,
chr21-43372411-43378616,
chr21-43574497-43576116,
chr21-43576516-43576782,
chr21-43578473-43579527,
chr21-43581013-43581404,
chr21-43581641-43582576,
chr21-43582859-43583337,
chr21-43583553-43584232,
chr21-43584938-43588325,
chr21-43589018-43591020,
chr21-43591407-43592525,
chr21-43592960-43594483,
chr21-43595004-43602071,
chr21-43650183-43650609,
chr21-43652784-43653261,
chr21-43653524-43654073,
chr21-43654592-43655821,
chr21-43657025-43661637,
chr21-43663113-43663746,
chr21-43665582-43666779,
chr21-43667345-43668735,
chr21-43669130-43669692,
chr21-43669978-43670612,
chr21-43671144-43671960,
chr21-43672190-43672490,
chr21-43673349-43673603,
chr21-43745728-43760952,
chr21-43761154-43780032,
chr21-43780561-43783971,
chr21-43784528-43784755,
chr21-43785556-43790918,
chr21-43791128-43792803,
chr21-43793228-43795435,
chr21-43796477-43821123,
chr21-43821535-43822584,
chr21-43823281-43831732,
chr21-43831999-43836730,
chr21-43838775-43839950,
chr21-43841496-43841801,
chr21-43842220-43843844,
chr21-43844363-43846062,
chr21-43846899-43848050,
chr21-43848774-43849113,
chr21-43849633-43862147,
chr21-43949301-43950152,
chr21-43950547-43953443,
chr21-43953873-43955291,
chr21-43955636-43960547,
chr21-43960797-43961167,
chr21-43961712-43962335,
chr21-43962563-43962803,
chr21-43963229-43963703,
chr21-43964076-43965453,
chr21-43966040-43970312,
chr21-43970557-43970863,
chr21-43971213-43978635,
chr21-43978988-43982273,
chr21-43982497-43984376,
chr21-43984827-43986234,
chr21-43986653-43987350,
chr21-43987624-43990156,
chr21-43991128-43996175,
chr21-43996484-43996757,
chr21-43997663-43998474,
chr21-43999790-44003430,
chr21-44003656-44007434,
chr21-44007816-44008392,
chr21-44008742-44009011,
chr21-44009756-44016003,
chr21-44016585-44017233,
chr21-44018250-44019461,
chr21-44019691-44020615,
chr21-44021146-44022462,
chr21-44022967-44023469,
chr21-44024829-44026370,
chr21-44026684-44026973,
chr21-44027505-44027848,
chr21-44028245-44030150,
chr21-44030507-44031055,
chr21-44031429-44031975,
chr21-44032361-44032700,
chr21-44033569-44033850,
chr21-44034785-44035350,
chr21-44037935-44038524,
chr21-44038873-44039863,
chr21-44040458-44040984,
chr21-44041439-44041931,
chr21-44043223-44044061,
chr21-44044699-44045290,
chr21-44046465-44047576,
chr21-44048020-44048763,
chr21-44049059-44050644,
chr21-44051500-44052149,
chr21-44058034-44059019,
chr21-44060331-44060715,
chr21-44061133-44061570,
chr21-44062415-44062878,
chr21-44063088-44064391,
chr21-44065260-44065880,
chr21-44066159-44066445,
chr21-44067082-44068169,
chr21-44069413-44070104,
chr21-44070382-44070916,
chr21-44071581-44073072,
chr21-44074197-44074929,
chr21-44077348-44077570,
chr21-44078553-44078867,
chr21-44079138-44079687,
chr21-44081500-44084368,
chr21-44084897-44085581,
chr21-44086043-44086366,
chr21-44086762-44089972,
chr21-44090357-44091197,
chr21-44093882-44094111,
chr21-44094969-44096191,
chr21-44125194-44125764,
chr21-44127060-44127393,
chr21-44131339-44132312,
chr21-44132653-44134411,
chr21-44134730-44135728,
chr21-44136419-44149190,
chr21-44150556-44151003,
chr21-44153124-44161484,
chr21-44162052-44162520,
chr21-44163350-44164569,
chr21-44165080-44167741,
chr21-44170128-44171339,
chr21-44171699-44172159,
chr21-44172520-44173627,
chr21-44173865-44179849,
chr21-44180238-44182493,
chr21-44184317-44187032,
chr21-44188310-44188648,
chr21-44190305-44191390,
chr21-44192164-44195002,
chr21-44195889-44198272,
chr21-44199123-44199370,
chr21-44199741-44200119,
chr21-44279636-44308260,
chr21-44308534-44320510,
chr21-44320741-44336654,
chr21-44423218-44429069,
chr21-44430427-44430776,
chr21-44431429-44432042,
chr21-44432556-44445133,
chr21-44445469-44446997,
chr21-44447926-44448241,
chr21-44448540-44449289,
chr21-44449493-44451537,
chr21-44454404-44458504,
chr21-44458902-44463283,
chr21-44463692-44468246,
chr21-44470353-44470718,
chr21-44471953-44472348,
chr21-44474024-44474470,
chr21-44474734-44475102,
chr21-44477225-44484621,
chr21-44484854-44488529,
chr21-44488757-44489043,
chr21-44489948-44491135,
chr21-44493207-44494864,
chr21-44495074-44495354,
chr21-44496153-44497242,
chr21-44498019-44500523,
chr21-44699438-44700075,
chr21-44700276-44701276,
chr21-44701494-44705032,
chr21-44705399-44713548,
chr21-44716685-44716835,
chr21-44718430-44719031,
chr21-44721222-44721639,
chr21-44721934-44722192,
chr21-44723185-44724478,
chr21-44724719-44725397,
chr21-44726838-44728488,
chr21-44729260-44730345,
chr21-44730663-44731098,
chr21-44731456-44731919,
chr21-44732256-44737281,
chr21-44737533-44737682,
chr21-44738634-44738881,
chr21-44740003-44740352,
chr21-44741922-44744934,
chr21-44747978-44748295,
chr21-44748543-44754678,
chr21-44755085-44756295,
chr21-44756826-44769032,
chr21-44769388-44770132,
chr21-44770932-44775360,
chr21-44775568-44776159,
chr21-44778211-44780009,
chr21-44780867-44781685,
chr21-44784599-44786454,
chr21-44786700-44787596,
chr21-44788341-44788598,
chr21-44789666-44790323,
chr21-44791310-44795621,
chr21-44797363-44798119,
chr21-44799103-44805501,
chr21-44806825-44807985,
chr21-44808233-44808856,
chr21-44809850-44811758,
chr21-44812135-44814175,
chr21-44814747-44820942,
chr21-44823998-44825617,
chr21-44842094-44850066,
chr21-44850330-44851998,
chr21-44852235-44856871,
chr21-44857206-44857817,
chr21-44858153-44859485,
chr21-44860020-44862529,
chr21-44862997-44876511,
chr21-44876848-44922035,
chr21-44922496-44936465,
chr21-44937160-44937800,
chr21-44938036-44942579,
chr21-44943111-44946058,
chr21-44946260-44956117,
chr21-45124436-45132048,
chr21-45132786-45143934,
chr21-45145219-45145603,
chr21-45145953-45146151,
chr21-45147401-45149408,
chr21-45316533-45338135,
chr21-45339035-45339421,
chr21-45340328-45340876,
chr21-45341176-45342108,
chr21-45342847-45354233,
chr21-45487915-45502397,
chr21-45502617-45502900,
chr21-45503606-45519118,
chr21-45522806-45526243,
chr21-45526587-45546954,
chr21-45549108-45549455,
chr21-45549738-45561026,
chr21-45625655-45625928,
chr21-45629009-45638293,
chr21-45639143-45646446,
chr21-45824560-45825827,
chr21-45826840-45830627,
chr21-45830839-45831391,
chr21-45831779-45832772,
chr21-45833478-45836709,
chr21-45837172-45837882,
chr21-45844115-45844699,
chr21-45845305-45846222,
chr21-45846697-45847005,
chr21-45847320-45849116,
-
Co-expression with cohesin genes Rho = 0.4674
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.202
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.832
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: IMR-90,MCF-10A,TAMR-MCF7,MB157,Keratinocytes192627,H1-Mesenchymal,H1-Mesendoderm,Olfactory,MCF-7,HEK293T,GM12878,K-562,A-549,CyT49-pancreatic,HFFc6,HeLa-S3,H1-Trophectoderm,SU-DHL-2,H9-hESC,iPSC,Liver,OCI-AML-3,HCT-116,Germinal-Center-B,REC-1,Hep-G2,H1-hESC,HCC1599,Motor-Neuron,NaiveB,U-937,BMEC,HUES64,CyT49-hESC,HUVEC,HL-60,RT-112,CyT49-endoderm,KBM-7,CyT49-Gut,CC-2551,HAP1,HFF-hTERT,MCF7-FASR
- Related loop:
chr21:27500000-27525000~~chr21:44275000-44300000,
chr21:42525000-42550000~~chr21:44325000-44350000,
chr21:42975000-43000000~~chr21:44325000-44350000,
chr21:43175000-43200000~~chr21:44275000-44300000,
chr21:43275000-43300000~~chr21:44275000-44300000,
chr21:43300000-43325000~~chr21:44275000-44300000,
chr21:43300000-43325000~~chr21:44300000-44325000,
chr21:43325000-43350000~~chr21:44275000-44300000,
chr21:43325000-43350000~~chr21:44300000-44325000,
chr21:43350000-43375000~~chr21:44275000-44300000,
chr21:43350000-43375000~~chr21:44300000-44325000,
chr21:43350000-43375000~~chr21:44325000-44350000,
chr21:43575000-43600000~~chr21:44325000-44350000,
chr21:43650000-43675000~~chr21:44325000-44350000,
chr21:43750000-43775000~~chr21:44325000-44350000,
chr21:43775000-43800000~~chr21:44275000-44300000,
chr21:43800000-43825000~~chr21:44275000-44300000,
chr21:43800000-43825000~~chr21:44300000-44325000,
chr21:43825000-43850000~~chr21:44275000-44300000,
chr21:43825000-43850000~~chr21:44300000-44325000,
chr21:43950000-43975000~~chr21:44275000-44300000,
chr21:43950000-43975000~~chr21:44300000-44325000,
chr21:43975000-44000000~~chr21:44275000-44300000,
chr21:43975000-44000000~~chr21:44300000-44325000,
chr21:44000000-44025000~~chr21:44275000-44300000,
chr21:44000000-44025000~~chr21:44325000-44350000,
chr21:44025000-44050000~~chr21:44275000-44300000,
chr21:44025000-44050000~~chr21:44300000-44325000,
chr21:44050000-44075000~~chr21:44275000-44300000,
chr21:44050000-44075000~~chr21:44300000-44325000,
chr21:44075000-44100000~~chr21:44275000-44300000,
chr21:44075000-44100000~~chr21:44300000-44325000,
chr21:44075000-44100000~~chr21:44325000-44350000,
chr21:44125000-44150000~~chr21:44275000-44300000,
chr21:44150000-44175000~~chr21:44275000-44300000,
chr21:44175000-44200000~~chr21:44275000-44300000,
chr21:44175000-44200000~~chr21:44300000-44325000,
chr21:44175000-44200000~~chr21:44325000-44350000,
chr21:44300000-44325000~~chr21:44800000-44825000,
chr21:44302251-44303455~~chr21:44478082-44480854,
chr21:44310105-44311818~~chr21:44478082-44480854,
chr21:44310168-44311527~~chr21:44479026-44480810,
chr21:44325000-44350000~~chr21:44425000-44450000,
chr21:44325000-44350000~~chr21:44450000-44475000,
chr21:44325000-44350000~~chr21:44475000-44500000,
chr21:44325000-44350000~~chr21:44700000-44725000,
chr21:44325000-44350000~~chr21:44725000-44750000,
chr21:44325000-44350000~~chr21:44750000-44775000,
chr21:44325000-44350000~~chr21:44775000-44800000,
chr21:44325000-44350000~~chr21:44800000-44825000,
chr21:44325000-44350000~~chr21:44850000-44875000,
chr21:44325000-44350000~~chr21:44875000-44900000,
chr21:44325000-44350000~~chr21:44900000-44925000,
chr21:44325000-44350000~~chr21:44925000-44950000,
chr21:44325000-44350000~~chr21:45125000-45150000,
chr21:44325000-44350000~~chr21:45325000-45350000,
chr21:44325000-44350000~~chr21:45500000-45525000,
chr21:44325000-44350000~~chr21:45525000-45550000,
chr21:44325000-44350000~~chr21:45625000-45650000,
chr21:44325000-44350000~~chr21:45825000-45850000,
chr21:5025000-5050000~~chr21:44275000-44300000,
chr21:5050000-5075000~~chr21:44275000-44300000,
chr21:5100000-5125000~~chr21:44275000-44300000,
chr21:5100000-5125000~~chr21:44300000-44325000,
chr21:5100000-5125000~~chr21:44325000-44350000,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFIQYQWPF5, GSE95015, GSE43070, 4DNFITUOMFUQ, ENCSR794RDS, 4DNFIBN9K4V9, ENCSR852KQC, 4DNFIZ4F74QR, 4DNFI7H4II2V, 4DNFIEYQ5ZIR, 4DNFIREVU1Z5, 4DNFIA6NSSBJ, 4DNFI9VXTBE2, 4DNFIKYXMF1E, GSE97394, 4DNFICEGAHRC, 4DNFIE8T8JZ8, 4DNFI1E6NJQJ, 4DNFI9YAVTI1, 4DNFI6XD6JAQ, 4DNFISPUVQHA, 4DNFIK61ILGM, GSE116872, ENCSR305RTT, GSE105028, 4DNFIBKZK63V, 4DNFIQWD8ZYD, 4DNFI3CFMRID, ENCSR662QKG, GSE118716, ENCSR499RVD, 4DNFIB7QTIMH, 4DNFIBXWIH8J, 4DNFIJWBWE41, 4DNFICSTCJQZ, GSE155380, 4DNFIIMZB6Y9, GSE80820, GSE52457, Direct, 4DNFIAS8LV1C, 4DNFIV56OFE3, 4DNFIYIAUEPW, ENCSR244BBG, 4DNFI9815EEJ, 4DNFI9ZWZ5BS, 4DNFI2J1ODWB, 4DNFIVJ3IIQL, 4DNFIQ2687RT, 4DNFIFLJLIS5, 4DNFIDBIEXI7, 4DNFIDZT7PR8, 4DNFIZGCA8AH, 4DNFIH7TH4MF, 4DNFIT96Z365, 4DNFIH2A7IKF, 4DNFIWZEN3FF, ENCSR194SRI, 4DNFIBRSIPE4, 4DNFIR8OU6QJ, 4DNFI5CGQ46V, 4DNFIE8E4ANZ, GSE120294, GSE84022, 4DNFIW8TIFI5, ENCSR410MDC, 4DNFIMEG1QIC, 4DNFIXU2KPNQ, 4DNFIBM714BP, 4DNFIFHU75I5, 4DNFIYD8LO9Z, ENCSR123UVP, 4DNFIL9M97T2, 4DNFIJBJ6QVH, 4DNFI3A3VYWU, ENCSR637QCS, 4DNFIM2BMJ33, GSE165038, 4DNFIALNLR78, 4DNFIBY3UHJB, 4DNFIYDBBSE3, 4DNFIEJEFCAM, ENCSR393LOP, GSE44267, 4DNFIPAF4PYT, GSE48592, 4DNFIE5TEYK7, 4DNFIJ8JKKWJ, 4DNFIFI6NIKJ, 4DNFIDKJFK2S, ENCSR094EIC, GSE58752, ENCSR507AHE, GSE116869, 4DNFI8649RQJ, GSE116875, 4DNFIMROE6N4, GSE108787, 4DNFI5SUHCGZ, ENCSR545YBD, 4DNFIILDWK8M, 4DNFIP25GZGA, ENCSR866FWQ, 4DNFIBCIA62Q, 4DNFII6AN691, GSE111537, GSE131580, 4DNFIV239W4L, 4DNFIOUSETUP, ENCSR128RPG, 4DNFISTWNV9C, 4DNFI6JJQKFJ, 4DNFI1UEG1HD, GSE101921, ENCSR228TUX, 4DNFI8JFOAJT, 4DNFIC3HAU11, 4DNFIQVMVRP6, 4DNFI5LCW273, 4DNFIP71EWXC, 4DNFINEQY95T, 4DNFILIM6FDL, 4DNFIHN2QSMX, 4DNFII84FBKM, 4DNFIVSCH2CH
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: HL-60,SLK,HPC,P3HR-1,U2OS,HeLa-S3
- Cohesin-DEGs, number of studies: 7
- Cohesin-DEGs, study: GSE140651,GSE131581,GSE119828,GSE138937,GSE89799,GSE130558
- Cohesin-DEGs, subunit: SA2,WAPL,CTCF,SMC1,Rad21,CdLS