Deatailed information for gene ENSG00000142178

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  • Basic information
  • CohesinDB ID: CDBG00008200
  • Gene Symbol: SIK1
  • Ensembl ID: ENSG00000142178
  • Gene locus: chr21:43414482-43427131 Strand: -
  • Gene type: protein_coding
  • Double-evidenced cohesin related CRMs
  • Whether cohesin-related CRMs (double-evidenced): True
  • All evidenced type: Interaction,DEGs
  • Regulatory cohesin (double-evidenced): chr21-43409116-43421927, chr21-43422309-43432234, chr21-43626450-43626836, chr21-43627385-43627862, chr21-43631250-43632687, chr21-43634076-43634294, chr21-43634658-43635007, chr21-43635772-43636021, chr21-43636596-43637015, chr21-43638930-43640728, chr21-43640994-43641471, chr21-43642814-43643056, chr21-43643270-43649915,
  • Co-expression with cohesin genes Rho = 0.0945 FDR = 0.0000
    (Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
  • Tissue specificity
  • Gene expression across tissues (TPM):
  • Tissue specificity of gene (Gini-coefficient): 0.597
    0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
  • Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.808
    0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
  • Cohesin-loop evidence
  • Whether has cohesin-loop: True
  • Involved cell types for loop evidence: H9-hESC,HFFc6,HCT-116,CyT49-hESC
  • Related loop: chr21:43425000-43450000~~chr21:43625000-43650000, chr21:6125000-6150000~~chr21:43400000-43425000,
  • Cohesin-loop type: HiC,Direct
  • Cohesin-loop study: 4DNFIEYQ5ZIR, 4DNFII6AN691, Direct, 4DNFIJ8JKKWJ, 4DNFIKYXMF1E, 4DNFIP71EWXC, 4DNFILIM6FDL, 4DNFIDZT7PR8, 4DNFI5SUHCGZ, 4DNFII84FBKM
  • Cohesin-loop subunit: Other
  • Cohesin-DEGs evidence
  • Whether cohesin DEGs: True
  • Involved cell types for DEG evidence: SLK,MCF-10A,U2OS,HeLa-S3,HeLa,NUGC-3
  • Cohesin-DEGs, number of studies: 8
  • Cohesin-DEGs, study: GSE137253,GSE101921,GSE71420,GSE138937,GSE89799,GSE130558
  • Cohesin-DEGs, subunit: WAPL,CTCF,Rad21,NIPBL
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