Deatailed information for gene ENSG00000142188
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00008204
- Gene Symbol: TMEM50B
- Ensembl ID: ENSG00000142188
-
Gene locus: chr21:33432484-33479943
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-32649686-32650031,
chr21-32652266-32654844,
chr21-32656100-32656468,
chr21-32658231-32658886,
chr21-32659615-32660147,
chr21-32660445-32661444,
chr21-32661750-32662259,
chr21-32668006-32668064,
chr21-32824831-32828372,
chr21-32830402-32830634,
chr21-32831636-32833765,
chr21-32834854-32835342,
chr21-32836285-32836542,
chr21-32844499-32845578,
chr21-32846527-32846785,
chr21-32905563-32905679,
chr21-32907895-32908656,
chr21-32911935-32912474,
chr21-32916458-32917800,
chr21-32918143-32919135,
chr21-32920512-32922573,
chr21-32922883-32923153,
chr21-32926434-32926668,
chr21-32929569-32931312,
chr21-32931964-32933359,
chr21-32934017-32934551,
chr21-32938921-32942303,
chr21-32943893-32944726,
chr21-32948912-32949468,
chr21-32951208-32951430,
chr21-32955846-32956667,
chr21-32958326-32958988,
chr21-32961985-32962736,
chr21-32965025-32966085,
chr21-32968711-32969012,
chr21-32970880-32971243,
chr21-32973939-32974357,
chr21-32975475-32976221,
chr21-32976543-32977058,
chr21-32977580-32977963,
chr21-32978797-32979512,
chr21-32983065-32983400,
chr21-32986202-32986308,
chr21-32989013-32989362,
chr21-32990696-32991086,
chr21-32991381-32992043,
chr21-32992487-32996486,
chr21-32999540-32999696,
chr21-33018853-33032029,
chr21-33032493-33034874,
chr21-33035105-33037170,
chr21-33039667-33039909,
chr21-33040959-33041685,
chr21-33042060-33043831,
chr21-33046659-33047090,
chr21-33047338-33047839,
chr21-33049543-33050194,
chr21-33051204-33051475,
chr21-33052029-33052404,
chr21-33055871-33056524,
chr21-33057391-33058153,
chr21-33058371-33061110,
chr21-33061664-33062185,
chr21-33064260-33064998,
chr21-33065589-33066026,
chr21-33067051-33068063,
chr21-33069494-33072319,
chr21-33176533-33177231,
chr21-33178927-33179239,
chr21-33180031-33180867,
chr21-33181665-33182455,
chr21-33183559-33184328,
chr21-33185051-33185236,
chr21-33185475-33185847,
chr21-33186452-33186919,
chr21-33189336-33190586,
chr21-33191132-33191643,
chr21-33192567-33193025,
chr21-33193411-33193657,
chr21-33194152-33195061,
chr21-33195338-33206151,
chr21-33206645-33209519,
chr21-33209798-33210131,
chr21-33211272-33213452,
chr21-33215011-33217335,
chr21-33219732-33220309,
chr21-33222873-33223242,
chr21-33224686-33226597,
chr21-33227306-33234986,
chr21-33235935-33240451,
chr21-33241032-33241987,
chr21-33242428-33243401,
chr21-33243836-33246483,
chr21-33246774-33247187,
chr21-33247456-33248264,
chr21-33248634-33250562,
chr21-33322068-33327091,
chr21-33327900-33328437,
chr21-33328733-33329063,
chr21-33330820-33332435,
chr21-33332687-33333184,
chr21-33333599-33333915,
chr21-33334567-33335084,
chr21-33337603-33338145,
chr21-33338686-33340327,
chr21-33340630-33341347,
chr21-33341696-33343063,
chr21-33343933-33344156,
chr21-33346315-33351403,
chr21-33354048-33354418,
chr21-33355143-33356443,
chr21-33356778-33357973,
chr21-33359012-33364862,
chr21-33365781-33366490,
chr21-33367651-33369218,
chr21-33369612-33369909,
chr21-33370154-33370407,
chr21-33371268-33371854,
chr21-33372144-33385560,
chr21-33427110-33427633,
chr21-33428595-33430128,
chr21-33430846-33431848,
chr21-33432435-33436842,
chr21-33437463-33438154,
chr21-33438470-33439663,
chr21-33440299-33447453,
chr21-33448010-33448871,
chr21-33449679-33449894,
chr21-33450273-33450522,
chr21-33451723-33452456,
chr21-33456202-33456396,
chr21-33463002-33463264,
chr21-33464168-33464731,
chr21-33465490-33466234,
chr21-33467295-33467688,
chr21-33470245-33470858,
chr21-33471801-33472724,
chr21-33474539-33475875,
chr21-33476207-33476831,
chr21-33477518-33481114,
chr21-33481535-33482250,
chr21-33484533-33485150,
chr21-33490969-33492642,
chr21-33892684-33896819,
-
Co-expression with cohesin genes Rho = 0.6196
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.294
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.864
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: IMR-90,MCF-10A,TAMR-MCF7,MB157,DU145,Keratinocytes192627,GM12892,K1,hTERT-HME1,H1-Mesenchymal,H1-Mesendoderm,Olfactory,Hepatocyte-H9,GM19239,MCF-7,GM12891,SARS-Cov2-olfactory,GM12878,K-562,CyT49-pancreatic,HFFc6,PAEC,HeLa-S3,SU-DHL-2,H9-hESC,KU-19-19,Primed-hESC,NCI-H1437,iPSC,Liver,ARPE-19,HCT-116,REC-1,Hep-G2,HT-1197,H1-hESC,HCC1599,GM19238,HT-1376,Motor-Neuron,MSLCL,NaiveB,HUES64,SU-DHL-4,HUVEC,NPC-H9,RT-112,Skin-Fibroblast,Jurkat,CC-2551,HFF-hTERT,HAP1,MCF7-FASR,U251
- Related loop:
chr21:27500000-27525000~~chr21:33475000-33500000,
chr21:32650000-32675000~~chr21:33425000-33450000,
chr21:32650000-32675000~~chr21:33450000-33475000,
chr21:32652869-32654298~~chr21:33444420-33446284,
chr21:32825000-32850000~~chr21:33425000-33450000,
chr21:32825000-32850000~~chr21:33450000-33475000,
chr21:32900000-32925000~~chr21:33425000-33450000,
chr21:32925000-32950000~~chr21:33425000-33450000,
chr21:32925000-32950000~~chr21:33450000-33475000,
chr21:32939681-32941566~~chr21:33444394-33446526,
chr21:32950000-32975000~~chr21:33450000-33475000,
chr21:32975000-33000000~~chr21:33425000-33450000,
chr21:33025000-33050000~~chr21:33425000-33450000,
chr21:33025000-33050000~~chr21:33450000-33475000,
chr21:33050000-33075000~~chr21:33450000-33475000,
chr21:33175000-33200000~~chr21:33425000-33450000,
chr21:33196199-33197967~~chr21:33444382-33446347,
chr21:33198398-33200659~~chr21:33444682-33446480,
chr21:33198546-33200679~~chr21:33444546-33446097,
chr21:33199025-33201086~~chr21:33444396-33446544,
chr21:33199028-33200850~~chr21:33444393-33446601,
chr21:33199037-33200983~~chr21:33444394-33446526,
chr21:33199045-33200951~~chr21:33444636-33446481,
chr21:33199050-33200800~~chr21:33443901-33446577,
chr21:33199050-33200857~~chr21:33444407-33446602,
chr21:33199054-33200784~~chr21:33444405-33446286,
chr21:33199054-33200920~~chr21:33444381-33446578,
chr21:33199055-33200924~~chr21:33444392-33446476,
chr21:33199055-33201024~~chr21:33444393-33446535,
chr21:33199058-33200673~~chr21:33444549-33446058,
chr21:33199058-33201037~~chr21:33444352-33446507,
chr21:33199059-33200758~~chr21:33444411-33446307,
chr21:33199061-33200809~~chr21:33443867-33446335,
chr21:33199061-33200994~~chr21:33444395-33446546,
chr21:33199063-33200997~~chr21:33444390-33446463,
chr21:33199064-33200992~~chr21:33444374-33446541,
chr21:33199071-33200963~~chr21:33434105-33435828,
chr21:33199071-33200963~~chr21:33444382-33446347,
chr21:33199071-33200963~~chr21:33478656-33481090,
chr21:33199073-33200905~~chr21:33444418-33446468,
chr21:33199073-33200975~~chr21:33444374-33446510,
chr21:33199075-33200850~~chr21:33444400-33446333,
chr21:33199075-33200916~~chr21:33444399-33446509,
chr21:33199076-33200916~~chr21:33444431-33446547,
chr21:33199079-33200988~~chr21:33443815-33446553,
chr21:33199079-33200999~~chr21:33443868-33446510,
chr21:33199081-33200983~~chr21:33444401-33446475,
chr21:33199086-33200764~~chr21:33444420-33446284,
chr21:33199087-33200894~~chr21:33444395-33446595,
chr21:33199100-33200791~~chr21:33444407-33446481,
chr21:33199101-33200973~~chr21:33444376-33446489,
chr21:33199111-33200695~~chr21:33444601-33446061,
chr21:33199120-33200900~~chr21:33444450-33446275,
chr21:33199124-33200675~~chr21:33444541-33446079,
chr21:33199126-33200779~~chr21:33444632-33446271,
chr21:33199158-33200692~~chr21:33444614-33446077,
chr21:33199174-33200665~~chr21:33444604-33446075,
chr21:33199181-33200686~~chr21:33444661-33446059,
chr21:33200000-33225000~~chr21:33425000-33450000,
chr21:33200000-33225000~~chr21:33450000-33475000,
chr21:33214817-33217264~~chr21:33441565-33443170,
chr21:33225000-33250000~~chr21:33425000-33450000,
chr21:33325000-33350000~~chr21:33425000-33450000,
chr21:33325000-33350000~~chr21:33450000-33475000,
chr21:33350000-33375000~~chr21:33450000-33475000,
chr21:33360009-33362674~~chr21:33444395-33446546,
chr21:33360017-33362749~~chr21:33444399-33446509,
chr21:33360045-33362734~~chr21:33444390-33446463,
chr21:33360121-33362991~~chr21:33444374-33446510,
chr21:33360130-33362524~~chr21:33444431-33446547,
chr21:33360132-33362704~~chr21:33444396-33446544,
chr21:33360151-33362730~~chr21:33443867-33446335,
chr21:33360153-33362582~~chr21:33444393-33446535,
chr21:33360157-33362875~~chr21:33444546-33446097,
chr21:33360173-33362129~~chr21:33444604-33446075,
chr21:33360203-33362100~~chr21:33444407-33446481,
chr21:33360213-33362978~~chr21:33444400-33446333,
chr21:33360224-33362415~~chr21:33444418-33446468,
chr21:33360228-33362109~~chr21:33444451-33446541,
chr21:33360313-33362104~~chr21:33444549-33446058,
chr21:33478460-33481029~~chr21:33894201-33895840,
chr21:33478501-33481049~~chr21:33490733-33492612,
chr21:33478624-33481448~~chr21:33894294-33895564,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFIQYQWPF5, ENCSR794RDS, 4DNFIBN9K4V9, ENCSR852KQC, ENCSR361AYD, 4DNFIZ4F74QR, 4DNFI7H4II2V, ENCSR350NJV, 4DNFIEYQ5ZIR, 4DNFIA6NSSBJ, 4DNFI9VXTBE2, ENCSR668RDP, 4DNFIL5K3MA1, GSE97394, 4DNFICEGAHRC, 4DNFI9YAVTI1, ENCSR658RQQ, ENCSR299VMZ, 4DNFI6XD6JAQ, GSE112000, 4DNFIK61ILGM, GSE108869, GSE116872, 4DNFIAWVDQ8C, ENCSR305RTT, ENCSR000FDB, 4DNFI7XAZNNQ, ENCSR527RXH, GSE105028, ENCSR833CMG, ENCSR033GUP, 4DNFIQWD8ZYD, 4DNFI3CFMRID, GSE118716, GSE69643, GSE155380, 4DNFIJWBWE41, 4DNFICSTCJQZ, ENCSR587DSF, ENCSR452NHL, 4DNFIIMZB6Y9, GSE80820, GSE52457, Direct, ENCSR314HAC, ENCSR479MTN, 4DNFIX7H3CE2, 4DNFIYIAUEPW, ENCSR991JXX, 4DNFI9815EEJ, 4DNFI9ZWZ5BS, 4DNFIVJ3IIQL, 4DNFI2J1ODWB, 4DNFIFLJLIS5, 4DNFIDBIEXI7, 4DNFIDZT7PR8, 4DNFIZGCA8AH, 4DNFIH7TH4MF, 4DNFIWZEN3FF, 4DNFIR8OU6QJ, 4DNFI5CGQ46V, GSE120294, GSE84022, ENCSR672RHL, 4DNFIW8TIFI5, ENCSR410MDC, 4DNFIMEG1QIC, ENCSR732QOH, 4DNFIF2D3TL9, 4DNFIFHU75I5, ENCSR123UVP, 4DNFIL9M97T2, ENCSR550JLK, 4DNFIJ7OAIFQ, 4DNFIM2BMJ33, ENCSR386KHY, 4DNFIEJEFCAM, GSE125243, 4DNFIPAF4PYT, ENCSR404HWQ, 4DNFIJ8JKKWJ, 4DNFIDKJFK2S, ENCSR933UZH, ENCSR094EIC, GSE58752, GSE116869, 4DNFI8649RQJ, GSE116875, 4DNFIMROE6N4, GSE108787, 4DNFI5SUHCGZ, 4DNFIP25GZGA, 4DNFI6EIFUZI, ENCSR866FWQ, ENCSR381DCY, ENCSR981FNA, 4DNFIOUSETUP, ENCSR752QCX, ENCSR128RPG, 4DNFI1UEG1HD, GSE101921, ENCSR228TUX, 4DNFI8JFOAJT, 4DNFIOCW5AEM, 4DNFIC3HAU11, ENCSR247RGI, ENCSR110JOO, ENCSR338WUS, 4DNFI5LCW273, 4DNFIP71EWXC, 4DNFIHN2QSMX, 4DNFII84FBKM, 4DNFIVSCH2CH
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: HeLa,SLK,OCI-AML-3,HeLa-S3
- Cohesin-DEGs, number of studies: 5
- Cohesin-DEGs, study: GSE111537,GSE71420,GSE138937,GSE130558
- Cohesin-DEGs, subunit: ESCO1,SA2,WAPL,CTCF,Rad21