Deatailed information for gene ENSG00000142207
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00008207
- Gene Symbol: URB1
- Ensembl ID: ENSG00000142207
-
Gene locus: chr21:32311017-32393012
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-31783965-31788184,
chr21-31851015-31851259,
chr21-31851947-31852172,
chr21-31855210-31855593,
chr21-31857356-31857673,
chr21-31862100-31862414,
chr21-31863205-31863716,
chr21-31864316-31868880,
chr21-31869101-31869249,
chr21-31870626-31876394,
chr21-31907679-31909915,
chr21-32305776-32306803,
chr21-32307314-32307797,
chr21-32308617-32310741,
chr21-32311435-32312117,
chr21-32312390-32312669,
chr21-32313137-32313329,
chr21-32314800-32315445,
chr21-32315753-32317229,
chr21-32317515-32318325,
chr21-32319081-32319441,
chr21-32319827-32320459,
chr21-32320782-32321118,
chr21-32321609-32323171,
chr21-32323561-32324126,
chr21-32324577-32324835,
chr21-32328118-32330129,
chr21-32330737-32331391,
chr21-32331697-32332156,
chr21-32334113-32336149,
chr21-32336796-32337602,
chr21-32338550-32338885,
chr21-32339467-32340569,
chr21-32341274-32341813,
chr21-32345342-32345734,
chr21-32346632-32348222,
chr21-32348772-32352012,
chr21-32352521-32353449,
chr21-32353738-32354082,
chr21-32355525-32355982,
chr21-32357912-32358164,
chr21-32358689-32359007,
chr21-32359599-32360314,
chr21-32361562-32361824,
chr21-32362356-32363268,
chr21-32364267-32365213,
chr21-32365681-32366109,
chr21-32368660-32369139,
chr21-32371758-32373234,
chr21-32374258-32374575,
chr21-32377005-32377825,
chr21-32379033-32379799,
chr21-32381416-32385002,
chr21-32385478-32386069,
chr21-32386291-32386639,
chr21-32386870-32387447,
chr21-32388340-32390195,
chr21-32392163-32394318,
chr21-32394704-32394805,
chr21-32397459-32397677,
chr21-32450290-32453267,
chr21-32455431-32458336,
chr21-32458592-32459810,
chr21-32460801-32461622,
chr21-32462635-32464978,
chr21-32465888-32466157,
chr21-32467324-32467836,
chr21-32468636-32469297,
chr21-32470295-32471149,
chr21-32471386-32471935,
chr21-32472299-32473135,
chr21-32473670-32479773,
chr21-32569005-32571301,
chr21-32574949-32576472,
chr21-32576694-32579657,
chr21-32580005-32580573,
chr21-32580904-32582331,
chr21-32583026-32584806,
chr21-32585090-32585613,
chr21-32586300-32587559,
chr21-32590405-32590668,
chr21-32590870-32591197,
chr21-32592176-32593983,
chr21-32594251-32594977,
chr21-32595506-32596052,
chr21-32596424-32597923,
chr21-32598775-32602954,
chr21-32603193-32603581,
chr21-32604431-32605130,
chr21-32610128-32610562,
chr21-32610963-32613801,
chr21-32614942-32615265,
chr21-32618034-32618378,
chr21-32618831-32619540,
chr21-32620088-32620453,
chr21-32621102-32621530,
chr21-32624498-32625154,
chr21-32701356-32701691,
chr21-32702794-32703230,
chr21-32709291-32709521,
chr21-32710895-32711202,
chr21-32711670-32712519,
chr21-32717971-32718233,
chr21-32719376-32719676,
chr21-32721403-32721642,
chr21-32726512-32729587,
chr21-32732552-32732879,
chr21-32753932-32754480,
chr21-32757827-32758170,
chr21-32760835-32760984,
chr21-32769734-32773333,
chr21-32802706-32803538,
chr21-32803790-32803983,
chr21-32807381-32809281,
chr21-32810267-32810567,
chr21-32813428-32813843,
chr21-32818375-32819306,
chr21-32819649-32820186,
chr21-32821902-32822259,
chr21-32822753-32823042,
chr21-32824831-32828372,
chr21-33278068-33278366,
chr21-33278760-33279199,
chr21-33279478-33279883,
chr21-33281091-33281795,
chr21-33282298-33282619,
chr21-33283111-33284448,
chr21-33285676-33297310,
chr21-33297831-33303232,
chr21-33499516-33501924,
chr21-33502300-33502577,
chr21-33503183-33503797,
chr21-33505850-33506477,
chr21-33510139-33511457,
chr21-33512032-33512236,
chr21-33512943-33513570,
chr21-33514224-33515002,
chr21-33519154-33519618,
chr21-33521344-33521870,
chr21-33523382-33523959,
chr21-33525904-33526454,
chr21-33527092-33527653,
chr21-33529525-33530162,
chr21-33532796-33533465,
chr21-33533755-33533994,
chr21-33534392-33534803,
chr21-33535665-33535965,
chr21-33538818-33539084,
chr21-33539455-33539677,
chr21-33540381-33546238,
chr21-33546540-33546789,
chr21-33547026-33547321,
chr21-33547807-33548397,
chr21-33548736-33549040,
chr21-33549851-33553567,
chr21-33624861-33625767,
chr21-33627734-33628081,
chr21-33628806-33629574,
chr21-33632120-33632780,
chr21-33633469-33634006,
chr21-33634256-33634599,
chr21-33635325-33635974,
chr21-33637118-33637484,
chr21-33638225-33638513,
chr21-33640656-33646119,
chr21-33647554-33647858,
chr21-33648739-33649349,
chr21-33649579-33650417,
chr21-34330025-34330426,
chr21-34332972-34333971,
chr21-34334498-34338506,
chr21-34339763-34340385,
chr21-34340726-34341087,
chr21-34341939-34344393,
chr21-34344734-34353465,
-
Co-expression with cohesin genes Rho = 0.5853
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.323
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.894
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: IMR-90,TAMR-MCF7,hTERT-HME1,MCF-7,GM12878,K-562,A-549,HFFc6,HeLa-S3,KU-19-19,H9-hESC,iPSC,Hep-G2,Kelly,H1-hESC,HUVEC,CyT49-hESC,NPC-H9,Skin-Fibroblast,CC-2551,HFF-hTERT,HAP1,MCF7-FASR
- Related loop:
chr21:27500000-27525000~~chr21:32350000-32375000,
chr21:29025000-29050000~~chr21:32325000-32350000,
chr21:29050000-29075000~~chr21:32300000-32325000,
chr21:29050000-29075000~~chr21:32325000-32350000,
chr21:29050000-29075000~~chr21:32350000-32375000,
chr21:31784993-31787270~~chr21:32327704-32330556,
chr21:31850000-31875000~~chr21:32375000-32400000,
chr21:31907758-31909435~~chr21:32391718-32394270,
chr21:32300000-32325000~~chr21:32450000-32475000,
chr21:32300000-32325000~~chr21:32575000-32600000,
chr21:32300000-32325000~~chr21:32600000-32625000,
chr21:32300000-32325000~~chr21:32725000-32750000,
chr21:32305431-32307333~~chr21:32600164-32601910,
chr21:32325000-32350000~~chr21:32750000-32775000,
chr21:32325000-32350000~~chr21:33500000-33525000,
chr21:32325000-32350000~~chr21:33525000-33550000,
chr21:32350000-32375000~~chr21:32600000-32625000,
chr21:32350000-32375000~~chr21:32725000-32750000,
chr21:32350000-32375000~~chr21:32750000-32775000,
chr21:32350000-32375000~~chr21:33525000-33550000,
chr21:32350000-32375000~~chr21:34325000-34350000,
chr21:32359189-32360657~~chr21:32599840-32601900,
chr21:32375000-32400000~~chr21:32575000-32600000,
chr21:32375000-32400000~~chr21:32600000-32625000,
chr21:32375000-32400000~~chr21:32700000-32725000,
chr21:32375000-32400000~~chr21:32725000-32750000,
chr21:32375000-32400000~~chr21:32750000-32775000,
chr21:32375000-32400000~~chr21:32800000-32825000,
chr21:32375000-32400000~~chr21:33275000-33300000,
chr21:32375000-32400000~~chr21:33500000-33525000,
chr21:32375000-32400000~~chr21:33625000-33650000,
chr21:32375000-32400000~~chr21:34500000-34525000,
chr21:32383323-32384788~~chr21:32600164-32601910,
chr21:32385843-32387035~~chr21:32599838-32601801,
chr21:32391754-32394231~~chr21:32599840-32601943,
chr21:32391823-32394318~~chr21:32568639-32570686,
chr21:32391823-32394318~~chr21:32599840-32601900,
chr21:32391849-32394127~~chr21:32599840-32601796,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFI8649RQJ, 4DNFIQYQWPF5, ENCSR662QKG, GSE95015, 4DNFIATA1HD5, 4DNFIWZEN3FF, GSE94872, 4DNFIMROE6N4, GSE118716, ENCSR499RVD, GSE108787, 4DNFI5SUHCGZ, ENCSR852KQC, GSE126792, 4DNFIILDWK8M, ENCSR410MDC, 4DNFIMEG1QIC, ENCSR732QOH, 4DNFII6AN691, 4DNFIKYXMF1E, 4DNFIJWBWE41, 4DNFICSTCJQZ, ENCSR981FNA, 4DNFICEGAHRC, ENCSR587DSF, 4DNFIIMZB6Y9, 4DNFIE8T8JZ8, 4DNFI1E6NJQJ, GSE80820, 4DNFI9YAVTI1, 4DNFIBT4EAKN, GSE52457, 4DNFI3A3VYWU, Direct, 4DNFISPUVQHA, 4DNFIBY3UHJB, 4DNFI6JJQKFJ, 4DNFI1UEG1HD, 4DNFIK61ILGM, ENCSR991JXX, 4DNFIPAF4PYT, ENCSR404HWQ, ENCSR247RGI, 4DNFI5LCW273, 4DNFI2J1ODWB, 4DNFIFI6NIKJ, 4DNFIDKJFK2S, 4DNFIFLJLIS5, GSE105028, 4DNFIZGCA8AH, 4DNFIH7TH4MF, 4DNFII84FBKM, 4DNFIVSCH2CH
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: Keratinocytes,HCT116-mAID,SLK,HeLa-S3
- Cohesin-DEGs, number of studies: 4
- Cohesin-DEGs, study: GSE106886,GSE138937,GSE83870,GSE130558
- Cohesin-DEGs, subunit: WAPL,CTCF,SMC1,Rad21