Deatailed information for gene ENSG00000157578
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00010112
- Gene Symbol: LCA5L
- Ensembl ID: ENSG00000157578
-
Gene locus: chr21:39405727-39445778
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,
- Regulatory cohesin (double-evidenced):
chr21-38503073-38508323,
chr21-38524820-38525118,
chr21-38525327-38525704,
chr21-38528423-38528734,
chr21-38531264-38531985,
chr21-38544663-38545173,
chr21-38548479-38549133,
chr21-38800466-38816528,
chr21-38816889-38818881,
chr21-38819201-38823342,
chr21-38823665-38827360,
chr21-38849471-38854263,
chr21-38856453-38857719,
chr21-38858525-38859524,
chr21-38859766-38860539,
chr21-38861132-38861513,
chr21-38862000-38863279,
chr21-38864066-38864405,
chr21-38867234-38867512,
chr21-38869262-38870389,
chr21-38872690-38873110,
chr21-38873491-38873832,
chr21-38874324-38875151,
chr21-38999239-39001723,
chr21-39002157-39005860,
chr21-39006216-39008144,
chr21-39009600-39010167,
chr21-39010386-39017610,
chr21-39018454-39019370,
chr21-39019594-39020196,
chr21-39020597-39024249,
chr21-39024973-39026738,
chr21-39153009-39153827,
chr21-39173429-39176751,
chr21-39178845-39179222,
chr21-39180628-39180930,
chr21-39181962-39185522,
chr21-39189884-39190456,
chr21-39203404-39203730,
chr21-39204248-39204463,
chr21-39205366-39206009,
chr21-39208500-39209259,
chr21-39214963-39215242,
chr21-39215761-39216148,
chr21-39219118-39219418,
chr21-39221650-39221894,
chr21-39224700-39225233,
chr21-39227967-39228342,
chr21-39230638-39230782,
chr21-39233710-39233982,
chr21-39235801-39236518,
chr21-39244018-39244348,
chr21-39246748-39247115,
chr21-39249901-39249966,
chr21-39277603-39278116,
chr21-39281318-39282039,
chr21-39289740-39290081,
chr21-39295098-39295553,
chr21-39301995-39302301,
chr21-39303859-39304491,
chr21-39305444-39305836,
chr21-39306051-39306835,
chr21-39308133-39308430,
chr21-39308844-39309885,
chr21-39311213-39311463,
chr21-39311834-39323454,
chr21-39323856-39324540,
chr21-39326856-39327201,
chr21-39328143-39328508,
chr21-39329775-39330179,
chr21-39330451-39330860,
chr21-39332176-39332684,
chr21-39333291-39334572,
chr21-39335104-39335948,
chr21-39336590-39337662,
chr21-39338003-39338994,
chr21-39339920-39340238,
chr21-39342069-39342466,
chr21-39343271-39343467,
chr21-39343962-39344240,
chr21-39344676-39351972,
chr21-39402135-39402399,
chr21-39403382-39403965,
chr21-39404418-39404728,
chr21-39405210-39405509,
chr21-39409531-39409809,
chr21-39412553-39413050,
chr21-39413873-39414796,
chr21-39417782-39417992,
chr21-39419242-39419515,
chr21-39420248-39420774,
chr21-39421127-39421401,
chr21-39422232-39423256,
chr21-39424092-39424501,
chr21-39425591-39426058,
chr21-39427352-39427664,
chr21-39430503-39430780,
chr21-39431574-39431827,
chr21-39435612-39435881,
chr21-39436505-39436763,
chr21-39440305-39444075,
chr21-39444581-39446444,
chr21-39447001-39447710,
chr21-39699714-39700227,
chr21-39701576-39703321,
chr21-39704596-39707757,
chr21-39709616-39710268,
chr21-39710803-39711977,
chr21-39712178-39719074,
chr21-39720460-39720773,
chr21-39721276-39722005,
chr21-39723416-39724008,
-
Co-expression with cohesin genes Rho = 0.4641
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.649
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.890
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: MCF-7,HEK293T,Liver,IMR-90,K-562,H1-hESC,Jurkat,HFF-hTERT,HAP1,MCF7-FASR,HeLa-S3,H1-Trophectoderm,U-937,H9-hESC,SU-DHL-4
- Related loop:
chr21:38504739-38507562~~chr21:39440834-39442538,
chr21:38525000-38550000~~chr21:39450000-39475000,
chr21:38800000-38825000~~chr21:39425000-39450000,
chr21:38850000-38875000~~chr21:39400000-39425000,
chr21:39000000-39025000~~chr21:39425000-39450000,
chr21:39152734-39154644~~chr21:39445170-39446634,
chr21:39175000-39200000~~chr21:39400000-39425000,
chr21:39175000-39200000~~chr21:39425000-39450000,
chr21:39200000-39225000~~chr21:39400000-39425000,
chr21:39200000-39225000~~chr21:39425000-39450000,
chr21:39225000-39250000~~chr21:39400000-39425000,
chr21:39225000-39250000~~chr21:39425000-39450000,
chr21:39275000-39300000~~chr21:39400000-39425000,
chr21:39300000-39325000~~chr21:39400000-39425000,
chr21:39300000-39325000~~chr21:39425000-39450000,
chr21:39325000-39350000~~chr21:39425000-39450000,
chr21:39400000-39425000~~chr21:39700000-39725000,
- Cohesin-loop type: HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFI8649RQJ, 4DNFI3CFMRID, 4DNFIHMCILEN, 4DNFIWZEN3FF, GSE43070, 4DNFIDJ2JZ7Q, GSE118716, GSE108787, 4DNFIB7QTIMH, 4DNFIBN9K4V9, ENCSR361AYD, 4DNFI7H4II2V, 4DNFIW8TIFI5, 4DNFIP25GZGA, 4DNFIBM714BP, 4DNFIV239W4L, GSE52457, 4DNFI3A3VYWU, ENCSR658RQQ, 4DNFIM2BMJ33, Direct, 4DNFI6XD6JAQ, GSE165038, 4DNFISPUVQHA, 4DNFI8Y9SRP2, GSE44267, 4DNFIPAF4PYT, 4DNFIQVMVRP6, 4DNFIFI6NIKJ, 4DNFIDKJFK2S, GSE105028, 4DNFIDBIEXI7, GSE58752
- Cohesin-loop subunit: Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: False
-
Involved cell types for DEG evidence: U2OS,SLK
- Cohesin-DEGs, number of studies: 2
- Cohesin-DEGs, study: GSE138937,GSE89799
- Cohesin-DEGs, subunit: Rad21