Deatailed information for gene ENSG00000159259
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00010323
- Gene Symbol: CHAF1B
- Ensembl ID: ENSG00000159259
-
Gene locus: chr21:36385391-36419015
Strand: +
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-36125038-36126944,
chr21-36127229-36128557,
chr21-36128832-36129080,
chr21-36129740-36130699,
chr21-36132348-36133044,
chr21-36133297-36137447,
chr21-36138179-36138394,
chr21-36139440-36143477,
chr21-36143694-36144806,
chr21-36145249-36145917,
chr21-36146214-36147498,
chr21-36148387-36148829,
chr21-36149046-36149389,
chr21-36149733-36151341,
chr21-36152062-36154775,
chr21-36155298-36159915,
chr21-36160348-36160929,
chr21-36162643-36163290,
chr21-36163793-36164976,
chr21-36165429-36166440,
chr21-36166692-36167478,
chr21-36167980-36168299,
chr21-36169044-36170570,
chr21-36171056-36173134,
chr21-36173521-36174893,
chr21-36199941-36200843,
chr21-36201956-36204277,
chr21-36204496-36205970,
chr21-36207279-36213059,
chr21-36213261-36213784,
chr21-36215461-36216010,
chr21-36220646-36222170,
chr21-36224193-36224492,
chr21-36250101-36251132,
chr21-36252668-36253134,
chr21-36253649-36256653,
chr21-36258997-36259715,
chr21-36260022-36261928,
chr21-36262223-36263216,
chr21-36265080-36265691,
chr21-36267726-36268314,
chr21-36268639-36269527,
chr21-36270588-36270906,
chr21-36271142-36271832,
chr21-36272357-36274134,
chr21-36274538-36275152,
chr21-36383536-36383931,
chr21-36384976-36386612,
chr21-36387795-36388181,
chr21-36388570-36390448,
chr21-36390697-36390999,
chr21-36392384-36394412,
chr21-36396999-36397241,
chr21-36399798-36400258,
chr21-36400631-36402974,
chr21-36403437-36403958,
chr21-36404207-36404954,
chr21-36408129-36408499,
chr21-36411169-36411609,
chr21-36412195-36412659,
chr21-36413976-36414306,
chr21-36414631-36414945,
chr21-36415497-36416503,
chr21-36417281-36424270,
chr21-36476076-36480937,
chr21-36499698-36502459,
chr21-36502665-36508046,
chr21-36508508-36509460,
chr21-36509687-36510756,
chr21-36511314-36511916,
chr21-36512825-36514000,
chr21-36514562-36514704,
chr21-36514932-36516116,
chr21-36516886-36517136,
chr21-36518707-36520114,
chr21-36522371-36522616,
chr21-36522943-36523216,
chr21-36523577-36525374,
chr21-36575350-36575709,
chr21-36576412-36577230,
chr21-36583668-36584068,
chr21-36584895-36585487,
chr21-36585745-36586353,
chr21-36587320-36592079,
chr21-36592299-36593515,
chr21-36594289-36594685,
chr21-36597896-36598145,
chr21-36600818-36601345,
chr21-36604225-36607299,
chr21-36612683-36613591,
chr21-36615064-36615747,
chr21-36616639-36617355,
chr21-36626499-36626785,
chr21-36627115-36627703,
chr21-36628239-36628880,
chr21-36629116-36633556,
chr21-36635100-36635760,
chr21-36639730-36643030,
chr21-36643874-36644319,
chr21-36645284-36645814,
chr21-36646243-36646978,
chr21-36647229-36648099,
chr21-36649972-36650268,
chr21-36674474-36675018,
chr21-36679412-36679745,
chr21-36685090-36686439,
chr21-36689351-36689685,
chr21-36691769-36693953,
chr21-36694356-36695251,
chr21-36695763-36711052,
chr21-36713788-36714054,
chr21-36717947-36720220,
chr21-36722587-36724224,
chr21-36849359-36851035,
chr21-36852281-36852846,
chr21-36853092-36853523,
chr21-36853815-36855525,
chr21-36858096-36861901,
chr21-36863188-36863633,
chr21-36868703-36869527,
chr21-36873092-36873862,
chr21-36874166-36876283,
chr21-36900452-36900638,
chr21-36902278-36903030,
chr21-36906879-36907037,
chr21-36908112-36912037,
chr21-36912728-36913168,
chr21-36913831-36916029,
chr21-36916572-36919027,
chr21-36921025-36921843,
chr21-36922598-36923152,
chr21-36924393-36924624,
chr21-36925188-36930260,
chr21-36931558-36932127,
chr21-36932869-36933269,
chr21-36933777-36933972,
chr21-36936430-36937373,
chr21-36938461-36938855,
chr21-36939198-36940146,
chr21-36940753-36941319,
chr21-36941642-36942402,
chr21-36945889-36946126,
chr21-36946840-36947402,
chr21-36947671-36947946,
chr21-36949217-36949518,
chr21-37070631-37076219,
chr21-37076784-37077014,
chr21-37078520-37078699,
chr21-37079061-37080047,
chr21-37081855-37082126,
chr21-37082890-37083573,
chr21-37084687-37084979,
chr21-37085624-37086068,
chr21-37086511-37087720,
chr21-37089506-37089981,
chr21-37091613-37091912,
chr21-37093055-37093396,
chr21-37098838-37099047,
-
Co-expression with cohesin genes Rho = 0.3506
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.416
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.855
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: MCF-10A,TAMR-MCF7,MB157,DU145,Keratinocytes192627,GM12892,K1,Olfactory,Hepatocyte-H9,MCF-7,GM12891,GM12878,K-562,A-549,HFFc6,PAEC,HeLa-S3,LNCaP,SU-DHL-2,H9-hESC,NCI-H1437,ARPE-19,HT-1197,H1-hESC,HT-1376,Motor-Neuron,MSLCL,HUES64,SU-DHL-4,HUVEC,NPC-H9,RT-112,Skin-Fibroblast,CC-2551,HFF-hTERT,HAP1,MCF7-FASR
- Related loop:
chr21:34350000-34375000~~chr21:36375000-36400000,
chr21:34350000-34375000~~chr21:36400000-36425000,
chr21:36125000-36150000~~chr21:36375000-36400000,
chr21:36140628-36142797~~chr21:36388297-36390535,
chr21:36140648-36142704~~chr21:36389208-36390546,
chr21:36140783-36142792~~chr21:36388547-36390538,
chr21:36140808-36142792~~chr21:36389186-36390767,
chr21:36140808-36142792~~chr21:36419122-36421037,
chr21:36140824-36142795~~chr21:36389196-36390710,
chr21:36140824-36142795~~chr21:36419273-36421104,
chr21:36140829-36142646~~chr21:36389162-36390561,
chr21:36140830-36142847~~chr21:36389185-36390513,
chr21:36140835-36142753~~chr21:36388314-36390557,
chr21:36140837-36142525~~chr21:36389208-36390500,
chr21:36140838-36142786~~chr21:36388412-36390522,
chr21:36150000-36175000~~chr21:36375000-36400000,
chr21:36152221-36154286~~chr21:36388878-36390620,
chr21:36152248-36154218~~chr21:36389196-36390710,
chr21:36200000-36225000~~chr21:36375000-36400000,
chr21:36250000-36275000~~chr21:36375000-36400000,
chr21:36400000-36425000~~chr21:36500000-36525000,
chr21:36400000-36425000~~chr21:36575000-36600000,
chr21:36400000-36425000~~chr21:36600000-36625000,
chr21:36400000-36425000~~chr21:36625000-36650000,
chr21:36400000-36425000~~chr21:36675000-36700000,
chr21:36400000-36425000~~chr21:36700000-36725000,
chr21:36400000-36425000~~chr21:36850000-36875000,
chr21:36400000-36425000~~chr21:36900000-36925000,
chr21:36400000-36425000~~chr21:36925000-36950000,
chr21:36400000-36425000~~chr21:37075000-37100000,
chr21:36418841-36421262~~chr21:36588530-36590785,
chr21:36418841-36421262~~chr21:36926465-36928856,
chr21:36418853-36423205~~chr21:36588271-36590801,
chr21:36419097-36421364~~chr21:36926664-36928827,
chr21:36419122-36421037~~chr21:36926683-36929117,
chr21:36419158-36421245~~chr21:36588474-36590657,
chr21:36419182-36421107~~chr21:36588390-36590623,
chr21:36419182-36421107~~chr21:36926687-36928814,
chr21:36419184-36421121~~chr21:36926717-36929094,
chr21:36419194-36421140~~chr21:36588734-36590540,
chr21:36419201-36421142~~chr21:36588485-36590701,
chr21:36419201-36421142~~chr21:36926513-36928814,
chr21:36419216-36421134~~chr21:36588498-36590583,
chr21:36419216-36421134~~chr21:36926710-36929115,
chr21:36419217-36421314~~chr21:36926678-36929090,
chr21:36419245-36420874~~chr21:36588511-36590472,
chr21:36419258-36420992~~chr21:36588860-36590466,
chr21:36419274-36420828~~chr21:36926717-36928685,
chr21:36419274-36421021~~chr21:36588675-36590309,
chr21:36419280-36421083~~chr21:36588665-36590475,
chr21:36419280-36421083~~chr21:36926505-36928808,
chr21:36419354-36421097~~chr21:36503272-36505466,
chr21:36419354-36421097~~chr21:36588498-36590567,
chr21:36419354-36421097~~chr21:36630022-36631930,
chr21:36419354-36421097~~chr21:36853698-36855512,
chr21:36419354-36421097~~chr21:36926649-36929131,
chr21:36419354-36421097~~chr21:36929169-36930348,
chr21:36419356-36420914~~chr21:36588710-36590304,
chr21:36419396-36420907~~chr21:36927027-36928493,
chr21:36419406-36420906~~chr21:36927009-36928504,
chr21:36419466-36420997~~chr21:36916786-36918422,
chr21:36419507-36420817~~chr21:36927023-36928663,
chr21:36421367-36423313~~chr21:36588390-36590623,
chr21:36421381-36423343~~chr21:36588528-36590557,
chr21:36421400-36423189~~chr21:36588493-36590531,
chr21:36421415-36423297~~chr21:36926465-36928856,
chr21:36421419-36423290~~chr21:36588485-36590701,
chr21:36421419-36423290~~chr21:36926513-36928814,
chr21:36421424-36423153~~chr21:36588511-36590472,
chr21:36421453-36423350~~chr21:36477710-36479878,
chr21:36421453-36423350~~chr21:36588498-36590567,
chr21:36421457-36423277~~chr21:36588417-36590557,
chr21:36421469-36423169~~chr21:36588501-36590672,
chr21:36421646-36423206~~chr21:36588699-36590235,
chr21:36421690-36423243~~chr21:36588716-36590491,
chr21:36421690-36423243~~chr21:36926866-36928715,
chr21:36421736-36423241~~chr21:36926885-36928641,
chr21:36421773-36423174~~chr21:36588574-36590548,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFIQWD8ZYD, ENCSR662QKG, GSE95015, 4DNFIWZEN3FF, 4DNFI6CWNUFL, GSE94872, 4DNFIMROE6N4, GSE118716, 4DNFIE8E4ANZ, ENCSR499RVD, 4DNFIBN9K4V9, 4DNFI5SUHCGZ, 4DNFIPV5KFMK, ENCSR672RHL, 4DNFIZ4F74QR, 4DNFI7H4II2V, 4DNFIW8TIFI5, ENCSR410MDC, 4DNFIMEG1QIC, ENCSR732QOH, 4DNFIREVU1Z5, ENCSR113OIR, 4DNFI9VXTBE2, ENCSR668RDP, ENCSR381DCY, GSE155380, 4DNFIJWBWE41, ENCSR981FNA, GSE97394, ENCSR587DSF, ENCSR752QCX, ENCSR452NHL, 4DNFICEGAHRC, 4DNFIL9M97T2, ENCSR128RPG, 4DNFI9YAVTI1, 4DNFI3A3VYWU, ENCSR658RQQ, ENCSR299VMZ, ENCSR314HAC, Direct, 4DNFISPUVQHA, 4DNFIAS8LV1C, 4DNFIBY3UHJB, ENCSR386KHY, 4DNFIX7H3CE2, GSE101921, 4DNFII84FBKM, 4DNFIYIAUEPW, 4DNFIEJEFCAM, ENCSR244BBG, ENCSR393LOP, 4DNFIAWVDQ8C, 4DNFIOCW5AEM, 4DNFIC3HAU11, 4DNFIQVMVRP6, ENCSR255XYX, ENCSR000FDB, ENCSR247RGI, ENCSR110JOO, ENCSR338WUS, 4DNFIVJ3IIQL, ENCSR305RTT, ENCSR933UZH, ENCSR833CMG, 4DNFIDBIEXI7, 4DNFIDZT7PR8, 4DNFIFLJLIS5, GSE105028, GSE116869, ENCSR033GUP
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: MCF-7,HCT116-mAID,SLK,P3HR-1,K-562,Kelly,CMK,U2OS,Keratinocytes
- Cohesin-DEGs, number of studies: 11
- Cohesin-DEGs, study: GSE115253,GSE83870,GSE140651,GSE177045,GSE154086,GSE131448,GSE138937,GSE106886,GSE89799
- Cohesin-DEGs, subunit: SMC3,SA2,SMC1,Rad21,BORIS