Deatailed information for gene ENSG00000160188
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00010430
- Gene Symbol: RSPH1
- Ensembl ID: ENSG00000160188
-
Gene locus: chr21:42472485-42496246
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs
- Regulatory cohesin (double-evidenced):
chr21-41200720-41201085,
chr21-41203279-41204508,
chr21-41207311-41209537,
chr21-41213457-41213771,
chr21-41214800-41215219,
chr21-41216467-41217270,
chr21-41217596-41218016,
chr21-41218863-41219208,
chr21-41219451-41220069,
chr21-41221113-41223031,
chr21-41223341-41223563,
chr21-41224862-41225153,
chr21-41600668-41607029,
chr21-41607264-41617134,
chr21-41617741-41618159,
chr21-41619036-41619135,
chr21-41620001-41623327,
chr21-41649662-41650037,
chr21-41650707-41652356,
chr21-41653070-41654701,
chr21-41656820-41657981,
chr21-41658412-41661789,
chr21-41662180-41667516,
chr21-41667934-41670919,
chr21-41671179-41674646,
chr21-41698776-41700406,
chr21-41701336-41702512,
chr21-41703830-41708250,
chr21-41710305-41711418,
chr21-41711706-41713056,
chr21-41713475-41714677,
chr21-41715027-41718311,
chr21-41719102-41720033,
chr21-41720825-41721220,
chr21-41721582-41723534,
chr21-41724219-41724820,
chr21-41799784-41800050,
chr21-41800258-41800436,
chr21-41800941-41801669,
chr21-41801918-41803799,
chr21-41804360-41804854,
chr21-41805059-41805238,
chr21-41805853-41806997,
chr21-41807830-41808572,
chr21-41808928-41810866,
chr21-41811647-41812381,
chr21-41812630-41814016,
chr21-41814372-41823630,
chr21-41823944-41825655,
chr21-41898621-41901470,
chr21-41903610-41904218,
chr21-41905344-41905910,
chr21-41907516-41908154,
chr21-41908433-41908738,
chr21-41912525-41913615,
chr21-41913829-41916045,
chr21-41916566-41919291,
chr21-41919607-41924881,
chr21-41950243-41951395,
chr21-41951919-41960803,
chr21-41961161-41962054,
chr21-41962297-41963236,
chr21-41964196-41969097,
chr21-41970716-41971987,
chr21-41972592-41976832,
chr21-42103416-42126825,
chr21-42127155-42127810,
chr21-42128488-42129619,
chr21-42130648-42131154,
chr21-42133171-42133790,
chr21-42135118-42136218,
chr21-42136531-42136713,
chr21-42136966-42138370,
chr21-42139645-42142559,
chr21-42143139-42149312,
chr21-42149675-42151617,
chr21-42152798-42155831,
chr21-42156081-42158150,
chr21-42158837-42159271,
chr21-42159533-42167922,
chr21-42168175-42168574,
chr21-42169121-42169273,
chr21-42171081-42172120,
chr21-42172666-42173562,
chr21-42173962-42174405,
chr21-42299343-42300483,
chr21-42300983-42302568,
chr21-42302945-42303453,
chr21-42304539-42307451,
chr21-42307683-42313987,
chr21-42314400-42316186,
chr21-42316662-42318793,
chr21-42319099-42320523,
chr21-42320786-42322135,
chr21-42400535-42400843,
chr21-42401248-42401553,
chr21-42403523-42404340,
chr21-42405157-42405336,
chr21-42405775-42406562,
chr21-42410755-42412796,
chr21-42413040-42414011,
chr21-42414328-42417910,
chr21-42418387-42418668,
chr21-42422915-42428748,
chr21-42464964-42468175,
chr21-42468693-42469817,
chr21-42470571-42470719,
chr21-42471137-42471564,
chr21-42471844-42472360,
chr21-42473167-42473467,
chr21-42473712-42475050,
chr21-42475275-42477409,
chr21-42478322-42479169,
chr21-42480568-42481138,
chr21-42482081-42482692,
chr21-42485826-42486174,
chr21-42486445-42487207,
chr21-42488988-42489705,
chr21-42494711-42497356,
chr21-42499096-42500557,
chr21-42512399-42517747,
chr21-42517993-42518929,
chr21-42534381-42538581,
chr21-42550666-42551166,
chr21-42552612-42552929,
chr21-42553370-42553876,
chr21-42554156-42554862,
chr21-42555716-42557745,
chr21-42557991-42563561,
chr21-42563869-42567471,
chr21-42567836-42568107,
chr21-42568338-42571365,
chr21-42571820-42572304,
chr21-42572767-42573421,
chr21-42574597-42575565,
chr21-42576721-42576991,
chr21-42578056-42578346,
chr21-42578723-42581320,
chr21-42581763-42582576,
chr21-42583402-42584657,
chr21-42586456-42597158,
chr21-42597733-42599089,
chr21-42599440-42600439,
chr21-43262337-43262934,
chr21-43263265-43265021,
chr21-43265406-43280154,
chr21-43296982-43309547,
chr21-43311036-43327583,
-
Co-expression with cohesin genes Rho = 0.1385
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.677
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.844
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: MCF-7,NCI-H1437,RT-112,TAMR-MCF7,HT-1197,H1-hESC,Motor-Neuron,HFF-hTERT,MSLCL,HFFc6,MCF7-FASR,SU-DHL-2,H9-hESC,HUES64,SU-DHL-4
- Related loop:
chr21:41200000-41225000~~chr21:42475000-42500000,
chr21:41600000-41625000~~chr21:42450000-42475000,
chr21:41650000-41675000~~chr21:42475000-42500000,
chr21:41700000-41725000~~chr21:42475000-42500000,
chr21:41800000-41825000~~chr21:42475000-42500000,
chr21:41800000-41825000~~chr21:42500000-42525000,
chr21:41900000-41925000~~chr21:42475000-42500000,
chr21:41950000-41975000~~chr21:42475000-42500000,
chr21:42125000-42150000~~chr21:42450000-42475000,
chr21:42125000-42150000~~chr21:42475000-42500000,
chr21:42150000-42175000~~chr21:42450000-42475000,
chr21:42300000-42325000~~chr21:42450000-42475000,
chr21:42300000-42325000~~chr21:42500000-42525000,
chr21:42400000-42425000~~chr21:42500000-42525000,
chr21:42450000-42475000~~chr21:42550000-42575000,
chr21:42466723-42468288~~chr21:42517954-42519108,
chr21:42466723-42468288~~chr21:42536785-42538249,
chr21:42466738-42468349~~chr21:42512702-42515312,
chr21:42466738-42468349~~chr21:42536098-42538505,
chr21:42466750-42468364~~chr21:42534380-42538530,
chr21:42466752-42469410~~chr21:42536796-42538220,
chr21:42466778-42468284~~chr21:42536154-42538496,
chr21:42466880-42468218~~chr21:42535463-42538505,
chr21:42473977-42475276~~chr21:42512630-42515252,
chr21:42475000-42500000~~chr21:42575000-42600000,
chr21:42475000-42500000~~chr21:43250000-43275000,
chr21:42475000-42500000~~chr21:43300000-43325000,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
ENCSR128RPG, ENCSR550JLK, ENCSR658RQQ, Direct, 4DNFIDJ2JZ7Q, GSE118716, 4DNFIMROE6N4, 4DNFISPUVQHA, ENCSR833CMG, ENCSR386KHY, ENCSR794RDS, 4DNFI5SUHCGZ, GSE155380, GSE105028, 4DNFII84FBKM, GSE97394, ENCSR452NHL
- Cohesin-loop subunit: CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: MCF-7,CMK,iPSC-megakaryocytes,P3HR-1
- Cohesin-DEGs, number of studies: 4
- Cohesin-DEGs, study: GSE140651,GSE119828,GSE154086,GSE177045
- Cohesin-DEGs, subunit: CdLS,SMC1,Rad21,SA2