Deatailed information for gene ENSG00000160191
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00010432
- Gene Symbol: PDE9A
- Ensembl ID: ENSG00000160191
-
Gene locus: chr21:42653620-42775509
Strand: +
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs
- Regulatory cohesin (double-evidenced):
chr21-41200720-41201085,
chr21-41203279-41204508,
chr21-41207311-41209537,
chr21-41213457-41213771,
chr21-41214800-41215219,
chr21-41216467-41217270,
chr21-41217596-41218016,
chr21-41218863-41219208,
chr21-41219451-41220069,
chr21-41221113-41223031,
chr21-41223341-41223563,
chr21-41224862-41225153,
chr21-41698776-41700406,
chr21-41701336-41702512,
chr21-41703830-41708250,
chr21-41710305-41711418,
chr21-41711706-41713056,
chr21-41713475-41714677,
chr21-41715027-41718311,
chr21-41719102-41720033,
chr21-41720825-41721220,
chr21-41721582-41723534,
chr21-41724219-41724820,
chr21-41750044-41752982,
chr21-41753429-41753815,
chr21-41754380-41755068,
chr21-41755301-41757502,
chr21-41758041-41771900,
chr21-41772125-41773546,
chr21-41774945-41781439,
chr21-41898621-41901470,
chr21-41903610-41904218,
chr21-41905344-41905910,
chr21-41907516-41908154,
chr21-41908433-41908738,
chr21-41912525-41913615,
chr21-41913829-41916045,
chr21-41916566-41919291,
chr21-41919607-41924881,
chr21-42024136-42028162,
chr21-42028427-42029217,
chr21-42029433-42029726,
chr21-42031578-42034228,
chr21-42035231-42036340,
chr21-42037819-42042122,
chr21-42043276-42045446,
chr21-42047213-42050893,
chr21-42103416-42126825,
chr21-42127155-42127810,
chr21-42128488-42129619,
chr21-42130648-42131154,
chr21-42133171-42133790,
chr21-42135118-42136218,
chr21-42136531-42136713,
chr21-42136966-42138370,
chr21-42139645-42142559,
chr21-42143139-42149312,
chr21-42149675-42151617,
chr21-42272186-42275483,
chr21-42275794-42277332,
chr21-42278585-42283213,
chr21-42283471-42284076,
chr21-42284283-42285457,
chr21-42285916-42288654,
chr21-42289750-42290327,
chr21-42290743-42296744,
chr21-42298296-42298540,
chr21-42299343-42300483,
chr21-42300983-42302568,
chr21-42302945-42303453,
chr21-42304539-42307451,
chr21-42307683-42313987,
chr21-42314400-42316186,
chr21-42316662-42318793,
chr21-42319099-42320523,
chr21-42320786-42322135,
chr21-42550666-42551166,
chr21-42552612-42552929,
chr21-42553370-42553876,
chr21-42554156-42554862,
chr21-42555716-42557745,
chr21-42557991-42563561,
chr21-42563869-42567471,
chr21-42567836-42568107,
chr21-42568338-42571365,
chr21-42571820-42572304,
chr21-42572767-42573421,
chr21-42574597-42575565,
chr21-42576721-42576991,
chr21-42578056-42578346,
chr21-42578723-42581320,
chr21-42581763-42582576,
chr21-42583402-42584657,
chr21-42586456-42597158,
chr21-42597733-42599089,
chr21-42599440-42600439,
chr21-42601201-42601742,
chr21-42607142-42608454,
chr21-42609794-42610085,
chr21-42614071-42618253,
chr21-42618578-42619171,
chr21-42619649-42620219,
chr21-42620846-42621537,
chr21-42624120-42625917,
chr21-42648967-42651377,
chr21-42651659-42660395,
chr21-42660643-42661368,
chr21-42661749-42667131,
chr21-42667757-42669990,
chr21-42670294-42674908,
chr21-42676262-42677139,
chr21-42677464-42680918,
chr21-42681246-42681895,
chr21-42682647-42686811,
chr21-42687678-42689455,
chr21-42689874-42691124,
chr21-42692085-42693894,
chr21-42694195-42694540,
chr21-42695409-42697261,
chr21-42697642-42697964,
chr21-42698273-42698662,
chr21-42699236-42699751,
chr21-42702991-42704847,
chr21-42705334-42706618,
chr21-42707172-42707738,
chr21-42708001-42708873,
chr21-42711194-42712193,
chr21-42714071-42714371,
chr21-42715268-42715937,
chr21-42719553-42721821,
chr21-42722042-42725763,
chr21-42730966-42735509,
chr21-42735915-42736171,
chr21-42736532-42737441,
chr21-42737823-42739971,
chr21-42741003-42741674,
chr21-42742668-42742887,
chr21-42743465-42748459,
chr21-42749267-42749616,
chr21-42749851-42750087,
chr21-42750791-42751500,
chr21-42751805-42752432,
chr21-42753545-42754647,
chr21-42755098-42758193,
chr21-42758449-42764685,
chr21-42764938-42765068,
chr21-42765386-42766176,
chr21-42766664-42772453,
chr21-42772703-42773259,
chr21-42773602-42774406,
chr21-42774814-42776288,
chr21-42776828-42779070,
chr21-42779308-42780010,
chr21-42780698-42782627,
chr21-42782976-42784673,
chr21-42784971-42786842,
chr21-42787122-42787668,
chr21-42790449-42793799,
chr21-42794079-42794902,
chr21-42796065-42797183,
chr21-42799515-42801184,
chr21-42801570-42802027,
chr21-42804198-42804619,
chr21-42806323-42807117,
chr21-42807469-42808220,
chr21-42809607-42810029,
chr21-42810534-42811625,
chr21-42812043-42812143,
chr21-42812479-42812787,
chr21-42815294-42815581,
chr21-42816699-42821466,
chr21-42832131-42835353,
chr21-42859132-42861293,
chr21-42861653-42864957,
chr21-43000878-43004167,
chr21-43005014-43005958,
chr21-43006547-43007242,
chr21-43007563-43008111,
chr21-43008975-43009699,
chr21-43011079-43011547,
chr21-43012278-43013148,
chr21-43016030-43017256,
chr21-43018084-43019388,
chr21-43020175-43023005,
chr21-43023655-43024103,
chr21-43024487-43026869,
chr21-43027260-43028315,
chr21-43028717-43029018,
chr21-43029424-43030648,
chr21-43031865-43032624,
chr21-43033056-43033422,
chr21-43033645-43034830,
chr21-43036478-43039973,
chr21-43040304-43041198,
chr21-43041584-43043029,
chr21-43043372-43043773,
chr21-43044579-43047606,
chr21-43049093-43049369,
chr21-43049841-43050585,
chr21-43167531-43179410,
chr21-43179782-43180289,
chr21-43180997-43181922,
chr21-43186619-43189146,
chr21-43189488-43189736,
chr21-43190641-43195980,
chr21-43196363-43198075,
chr21-43202414-43202849,
chr21-43203180-43204296,
chr21-43205526-43206063,
chr21-43206324-43207655,
chr21-43207866-43208349,
chr21-43208557-43212285,
chr21-43296982-43309547,
chr21-43311036-43327583,
chr21-43328508-43351938,
chr21-43352261-43357227,
chr21-43357471-43370764,
chr21-43371758-43372139,
chr21-43372411-43378616,
chr21-43574497-43576116,
chr21-43576516-43576782,
chr21-43578473-43579527,
chr21-43581013-43581404,
chr21-43581641-43582576,
chr21-43582859-43583337,
chr21-43583553-43584232,
chr21-43584938-43588325,
chr21-43589018-43591020,
chr21-43591407-43592525,
chr21-43592960-43594483,
chr21-43595004-43602071,
chr21-43949301-43950152,
chr21-43950547-43953443,
chr21-43953873-43955291,
chr21-43955636-43960547,
chr21-43960797-43961167,
chr21-43961712-43962335,
chr21-43962563-43962803,
chr21-43963229-43963703,
chr21-43964076-43965453,
chr21-43966040-43970312,
chr21-43970557-43970863,
chr21-43971213-43978635,
-
Co-expression with cohesin genes Rho = 0.3629
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.515
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.876
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: TAMR-MCF7,DU145,K1,H1-Mesenchymal,H1-Mesendoderm,Olfactory,MCF-7,GM12891,GM12878,K-562,A-549,HFFc6,PAEC,HeLa-S3,H9-hESC,iPSC,Hep-G2,H1-hESC,U-937,HUES64,HUVEC,NPC-H9,CyT49-endoderm,HFF-hTERT,MCF7-FASR
- Related loop:
chr21:27500000-27525000~~chr21:42750000-42775000,
chr21:34150000-34175000~~chr21:42625000-42650000,
chr21:41200000-41225000~~chr21:42650000-42675000,
chr21:41700000-41725000~~chr21:42650000-42675000,
chr21:41700000-41725000~~chr21:42775000-42800000,
chr21:41750000-41775000~~chr21:42650000-42675000,
chr21:41900000-41925000~~chr21:42675000-42700000,
chr21:41900000-41925000~~chr21:42750000-42775000,
chr21:42025000-42050000~~chr21:42775000-42800000,
chr21:42125000-42150000~~chr21:42650000-42675000,
chr21:42125000-42150000~~chr21:42675000-42700000,
chr21:42125000-42150000~~chr21:42775000-42800000,
chr21:42275000-42300000~~chr21:42675000-42700000,
chr21:42275000-42300000~~chr21:42750000-42775000,
chr21:42275000-42300000~~chr21:42775000-42800000,
chr21:42300000-42325000~~chr21:42750000-42775000,
chr21:42300000-42325000~~chr21:42775000-42800000,
chr21:42550000-42575000~~chr21:42675000-42700000,
chr21:42575000-42600000~~chr21:42675000-42700000,
chr21:42575000-42600000~~chr21:42700000-42725000,
chr21:42575000-42600000~~chr21:42725000-42750000,
chr21:42575000-42600000~~chr21:42750000-42775000,
chr21:42575000-42600000~~chr21:42775000-42800000,
chr21:42600000-42625000~~chr21:42700000-42725000,
chr21:42600000-42625000~~chr21:42725000-42750000,
chr21:42625000-42650000~~chr21:42800000-42825000,
chr21:42625000-42650000~~chr21:43000000-43025000,
chr21:42625000-42650000~~chr21:43175000-43200000,
chr21:42650000-42675000~~chr21:42800000-42825000,
chr21:42650000-42675000~~chr21:43000000-43025000,
chr21:42650000-42675000~~chr21:43175000-43200000,
chr21:42650000-42675000~~chr21:43300000-43325000,
chr21:42650000-42675000~~chr21:43950000-43975000,
chr21:42651607-42653884~~chr21:42817557-42819404,
chr21:42651607-42653884~~chr21:42832835-42834223,
chr21:42651695-42653675~~chr21:42817609-42819795,
chr21:42651852-42655263~~chr21:42674003-42675277,
chr21:42651852-42655263~~chr21:42679083-42680634,
chr21:42651852-42655263~~chr21:42861258-42862634,
chr21:42651926-42653288~~chr21:42817594-42819293,
chr21:42651964-42653518~~chr21:42817467-42819560,
chr21:42652851-42655141~~chr21:42817499-42819241,
chr21:42675000-42700000~~chr21:42775000-42800000,
chr21:42675000-42700000~~chr21:42800000-42825000,
chr21:42675000-42700000~~chr21:43000000-43025000,
chr21:42675000-42700000~~chr21:43025000-43050000,
chr21:42675000-42700000~~chr21:43200000-43225000,
chr21:42675000-42700000~~chr21:43300000-43325000,
chr21:42675000-42700000~~chr21:43350000-43375000,
chr21:42700000-42725000~~chr21:42800000-42825000,
chr21:42725000-42750000~~chr21:43175000-43200000,
chr21:42725000-42750000~~chr21:43200000-43225000,
chr21:42725000-42750000~~chr21:43575000-43600000,
chr21:42750000-42775000~~chr21:43175000-43200000,
chr21:42775000-42800000~~chr21:43175000-43200000,
chr21:42775000-42800000~~chr21:43200000-43225000,
chr21:6425000-6450000~~chr21:42625000-42650000,
chr21:6425000-6450000~~chr21:42725000-42750000,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFIWZEN3FF, ENCSR194SRI, 4DNFIMROE6N4, GSE118716, 4DNFIE8E4ANZ, 4DNFIBN9K4V9, ENCSR545YBD, ENCSR672RHL, 4DNFI7H4II2V, ENCSR410MDC, ENCSR668RDP, 4DNFIJWBWE41, GSE97394, ENCSR587DSF, 4DNFIIMZB6Y9, 4DNFIOUSETUP, 4DNFIE8T8JZ8, GSE52457, ENCSR299VMZ, ENCSR314HAC, Direct, 4DNFI6XD6JAQ, 4DNFISPUVQHA, 4DNFIX7H3CE2, 4DNFIXWCLD4M, 4DNFI1UEG1HD, 4DNFIYDBBSE3, GSE165038, ENCSR393LOP, 4DNFIAWVDQ8C, 4DNFIQVMVRP6, ENCSR247RGI, 4DNFI5LCW273, 4DNFIVJ3IIQL, 4DNFIFI6NIKJ, 4DNFIDKJFK2S, 4DNFIFLJLIS5, GSE105028, 4DNFIDBIEXI7, 4DNFIVSCH2CH
- Cohesin-loop subunit: CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: HL-60,OCI-AML-3,TC-32,MCF-10A,U2OS
- Cohesin-DEGs, number of studies: 7
- Cohesin-DEGs, study: GSE111537,GSE111004,GSE101921,GSE131581,GSE89799
- Cohesin-DEGs, subunit: SA1,Rad21,SA2,CTCF