Deatailed information for gene ENSG00000160193
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00010433
- Gene Symbol: WDR4
- Ensembl ID: ENSG00000160193
-
Gene locus: chr21:42843093-42879531
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-41425596-41431302,
chr21-41431562-41433383,
chr21-41433595-41438072,
chr21-41438421-41440223,
chr21-41440635-41442106,
chr21-41442477-41454571,
chr21-41625452-41626403,
chr21-41627233-41628368,
chr21-41629667-41633608,
chr21-41634030-41636192,
chr21-41636682-41637531,
chr21-41638110-41638628,
chr21-41639388-41640365,
chr21-41640676-41643854,
chr21-41645785-41646060,
chr21-41647714-41649300,
chr21-41649662-41650037,
chr21-42103416-42126825,
chr21-42127155-42127810,
chr21-42128488-42129619,
chr21-42130648-42131154,
chr21-42133171-42133790,
chr21-42135118-42136218,
chr21-42136531-42136713,
chr21-42136966-42138370,
chr21-42139645-42142559,
chr21-42143139-42149312,
chr21-42149675-42151617,
chr21-42152798-42155831,
chr21-42156081-42158150,
chr21-42158837-42159271,
chr21-42159533-42167922,
chr21-42168175-42168574,
chr21-42169121-42169273,
chr21-42171081-42172120,
chr21-42172666-42173562,
chr21-42173962-42174405,
chr21-42299343-42300483,
chr21-42300983-42302568,
chr21-42302945-42303453,
chr21-42304539-42307451,
chr21-42307683-42313987,
chr21-42314400-42316186,
chr21-42316662-42318793,
chr21-42319099-42320523,
chr21-42320786-42322135,
chr21-42574597-42575565,
chr21-42576721-42576991,
chr21-42578056-42578346,
chr21-42578723-42581320,
chr21-42581763-42582576,
chr21-42583402-42584657,
chr21-42586456-42597158,
chr21-42597733-42599089,
chr21-42599440-42600439,
chr21-42651659-42660395,
chr21-42836729-42839000,
chr21-42839290-42843405,
chr21-42844462-42845085,
chr21-42845314-42846984,
chr21-42847259-42856312,
chr21-42856928-42857550,
chr21-42858264-42858922,
chr21-42859132-42861293,
chr21-42861653-42864957,
chr21-42865222-42866633,
chr21-42867885-42870709,
chr21-42872006-42873778,
chr21-42875265-42875657,
chr21-42875983-42876584,
chr21-42876831-42877399,
chr21-42877653-42880442,
chr21-42881000-42881276,
chr21-42881848-42882396,
chr21-43099852-43100255,
chr21-43104309-43104688,
chr21-43106709-43112150,
chr21-43112950-43113541,
chr21-43115966-43118415,
chr21-43167531-43179410,
chr21-43179782-43180289,
chr21-43180997-43181922,
chr21-43186619-43189146,
chr21-43189488-43189736,
chr21-43190641-43195980,
chr21-43196363-43198075,
chr21-43202414-43202849,
chr21-43203180-43204296,
chr21-43205526-43206063,
chr21-43206324-43207655,
chr21-43207866-43208349,
chr21-43208557-43212285,
chr21-43265406-43280154,
chr21-43280924-43283710,
chr21-43285633-43286421,
chr21-43287064-43289808,
chr21-43290025-43293553,
chr21-43294387-43294818,
chr21-43295496-43295735,
chr21-43296982-43309547,
chr21-43311036-43327583,
chr21-43328508-43351938,
chr21-43352261-43357227,
chr21-43357471-43370764,
chr21-43371758-43372139,
chr21-43372411-43378616,
chr21-43626450-43626836,
chr21-43627385-43627862,
chr21-43631250-43632687,
chr21-43634076-43634294,
chr21-43634658-43635007,
chr21-43635772-43636021,
chr21-43636596-43637015,
chr21-43638930-43640728,
chr21-43640994-43641471,
chr21-43642814-43643056,
chr21-43643270-43649915,
chr21-43650183-43650609,
chr21-43652784-43653261,
chr21-43653524-43654073,
chr21-43654592-43655821,
chr21-43657025-43661637,
chr21-43663113-43663746,
chr21-43665582-43666779,
chr21-43667345-43668735,
chr21-43669130-43669692,
chr21-43669978-43670612,
chr21-43671144-43671960,
chr21-43672190-43672490,
chr21-43673349-43673603,
chr21-43675087-43675363,
chr21-43676274-43676773,
chr21-43680040-43680760,
chr21-43680996-43681953,
chr21-43682266-43682785,
chr21-43683749-43684802,
chr21-43686488-43690745,
chr21-43691074-43692529,
chr21-43692796-43693611,
chr21-43693964-43694960,
chr21-43696123-43696928,
chr21-43697136-43699761,
chr21-43699974-43701662,
chr21-43761154-43780032,
chr21-43780561-43783971,
chr21-43784528-43784755,
chr21-43785556-43790918,
chr21-43791128-43792803,
chr21-43793228-43795435,
chr21-43796477-43821123,
chr21-44244978-44251442,
chr21-44251673-44252226,
chr21-44252559-44252895,
chr21-44253503-44259739,
chr21-44260974-44262029,
chr21-44262549-44268928,
chr21-44270131-44273478,
chr21-44273834-44274503,
chr21-44274897-44275317,
chr21-44799103-44805501,
chr21-44806825-44807985,
chr21-44808233-44808856,
chr21-44809850-44811758,
chr21-44812135-44814175,
chr21-44814747-44820942,
chr21-44823998-44825617,
chr21-44876848-44922035,
-
Co-expression with cohesin genes Rho = 0.5012
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.305
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.824
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: IMR-90,MCF-10A,GM19239,MCF-7,GM12878,K-562,A-549,HFFc6,HeLa-S3,SU-DHL-2,H9-hESC,iPSC,Hep-G2,H1-hESC,SU-DHL-4,CyT49-hESC,HL-60,NPC-H9,CyT49-endoderm,CyT49-Gut,HFF-hTERT,HAP1,MCF7-FASR
- Related loop:
chr21:28325000-28350000~~chr21:42850000-42875000,
chr21:41425000-41450000~~chr21:42825000-42850000,
chr21:41625000-41650000~~chr21:42825000-42850000,
chr21:42125000-42150000~~chr21:42825000-42850000,
chr21:42150000-42175000~~chr21:42825000-42850000,
chr21:42300000-42325000~~chr21:42850000-42875000,
chr21:42575000-42600000~~chr21:42825000-42850000,
chr21:42575000-42600000~~chr21:42850000-42875000,
chr21:42592083-42595449~~chr21:42863770-42864944,
chr21:42592330-42594539~~chr21:42861258-42862634,
chr21:42651852-42655263~~chr21:42861258-42862634,
chr21:42825000-42850000~~chr21:43675000-43700000,
chr21:42825000-42850000~~chr21:44900000-44925000,
chr21:42850000-42875000~~chr21:43100000-43125000,
chr21:42850000-42875000~~chr21:43175000-43200000,
chr21:42850000-42875000~~chr21:43200000-43225000,
chr21:42850000-42875000~~chr21:43275000-43300000,
chr21:42850000-42875000~~chr21:43300000-43325000,
chr21:42850000-42875000~~chr21:43350000-43375000,
chr21:42850000-42875000~~chr21:43650000-43675000,
chr21:42850000-42875000~~chr21:43675000-43700000,
chr21:42850088-42851920~~chr21:43644933-43647734,
chr21:42850353-42851585~~chr21:43645063-43647595,
chr21:42875000-42900000~~chr21:43175000-43200000,
chr21:42875000-42900000~~chr21:43325000-43350000,
chr21:42875000-42900000~~chr21:43350000-43375000,
chr21:42875000-42900000~~chr21:43625000-43650000,
chr21:42875000-42900000~~chr21:43650000-43675000,
chr21:42875000-42900000~~chr21:43775000-43800000,
chr21:42875000-42900000~~chr21:44250000-44275000,
chr21:42875000-42900000~~chr21:44800000-44825000,
chr21:6475000-6500000~~chr21:42875000-42900000,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFI8649RQJ, 4DNFIQYQWPF5, ENCSR662QKG, GSE95015, 4DNFITUOMFUQ, GSE118716, ENCSR499RVD, 4DNFIB7QTIMH, 4DNFI5SUHCGZ, ENCSR545YBD, GSE120294, 4DNFIPV5KFMK, 4DNFIILDWK8M, ENCSR410MDC, 4DNFIHKWIZ9T, 4DNFII6AN691, 4DNFIKYXMF1E, 4DNFIYD8LO9Z, GSE131580, 4DNFIJWBWE41, 4DNFICSTCJQZ, 4DNFIV239W4L, 4DNFICEGAHRC, 4DNFIIMZB6Y9, 4DNFI1E6NJQJ, ENCSR128RPG, GSE52457, 4DNFI3A3VYWU, ENCSR658RQQ, 4DNFIM2BMJ33, Direct, ENCSR479MTN, 4DNFIYDBBSE3, 4DNFI6JJQKFJ, GSE101921, 4DNFIK61ILGM, 4DNFIYIAUEPW, ENCSR244BBG, ENCSR393LOP, 4DNFIPAF4PYT, ENCSR247RGI, 4DNFI5LCW273, 4DNFI2J1ODWB, 4DNFIFI6NIKJ, 4DNFIQ2687RT, 4DNFIFLJLIS5, 4DNFINEQY95T, 4DNFIH7TH4MF, 4DNFII84FBKM, 4DNFIVSCH2CH
- Cohesin-loop subunit: SMC1,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: HCT116-mAID,HPC,HL-60,SLK,P3HR-1,Kelly,U2OS,HeLa-S3,Keratinocytes
- Cohesin-DEGs, number of studies: 10
- Cohesin-DEGs, study: GSE115253,GSE83870,GSE140651,GSE131581,GSE119828,GSE138937,GSE106886,GSE89799,GSE130558
- Cohesin-DEGs, subunit: SA2,WAPL,CTCF,SMC1,Rad21,BORIS,CdLS