Deatailed information for gene ENSG00000160199
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00010435
- Gene Symbol: PKNOX1
- Ensembl ID: ENSG00000160199
-
Gene locus: chr21:42974509-43033931
Strand: +
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-41649662-41650037,
chr21-41650707-41652356,
chr21-41653070-41654701,
chr21-41656820-41657981,
chr21-41658412-41661789,
chr21-41662180-41667516,
chr21-41667934-41670919,
chr21-41671179-41674646,
chr21-42047213-42050893,
chr21-42051580-42052235,
chr21-42053659-42066910,
chr21-42067521-42069314,
chr21-42069730-42069902,
chr21-42071020-42072208,
chr21-42072432-42077357,
chr21-42550666-42551166,
chr21-42552612-42552929,
chr21-42553370-42553876,
chr21-42554156-42554862,
chr21-42555716-42557745,
chr21-42557991-42563561,
chr21-42563869-42567471,
chr21-42567836-42568107,
chr21-42568338-42571365,
chr21-42571820-42572304,
chr21-42572767-42573421,
chr21-42574597-42575565,
chr21-42576721-42576991,
chr21-42578056-42578346,
chr21-42578723-42581320,
chr21-42581763-42582576,
chr21-42583402-42584657,
chr21-42586456-42597158,
chr21-42597733-42599089,
chr21-42599440-42600439,
chr21-42601201-42601742,
chr21-42607142-42608454,
chr21-42609794-42610085,
chr21-42614071-42618253,
chr21-42618578-42619171,
chr21-42619649-42620219,
chr21-42620846-42621537,
chr21-42624120-42625917,
chr21-42627563-42628293,
chr21-42630073-42631514,
chr21-42631721-42634284,
chr21-42635929-42639240,
chr21-42639776-42640077,
chr21-42640461-42640878,
chr21-42641160-42643201,
chr21-42643573-42644015,
chr21-42644311-42645944,
chr21-42646879-42647225,
chr21-42648967-42651377,
chr21-42651659-42660395,
chr21-42660643-42661368,
chr21-42661749-42667131,
chr21-42667757-42669990,
chr21-42670294-42674908,
chr21-42676262-42677139,
chr21-42677464-42680918,
chr21-42681246-42681895,
chr21-42682647-42686811,
chr21-42687678-42689455,
chr21-42689874-42691124,
chr21-42692085-42693894,
chr21-42694195-42694540,
chr21-42695409-42697261,
chr21-42697642-42697964,
chr21-42698273-42698662,
chr21-42699236-42699751,
chr21-42898938-42900986,
chr21-42901231-42902142,
chr21-42903879-42905128,
chr21-42905606-42906786,
chr21-42908791-42909506,
chr21-42909724-42911164,
chr21-42912357-42914258,
chr21-42914488-42914837,
chr21-42915076-42915684,
chr21-42916003-42917086,
chr21-42917709-42919392,
chr21-42919813-42921376,
chr21-42921622-42928571,
chr21-42928933-42932902,
chr21-42933507-42933865,
chr21-42936506-42943558,
chr21-42948707-42949766,
chr21-42955236-42958765,
chr21-42965885-42969571,
chr21-42970561-42971027,
chr21-42971699-42976556,
chr21-42977567-42978245,
chr21-42978524-42979165,
chr21-42979449-42979775,
chr21-42980073-42980693,
chr21-42981060-42983699,
chr21-42984049-42984123,
chr21-42984399-42985953,
chr21-42986206-42987380,
chr21-42987592-42989052,
chr21-42989441-42990324,
chr21-42991464-42993497,
chr21-42993747-42994516,
chr21-42996864-42997865,
chr21-42998695-42999369,
chr21-43000878-43004167,
chr21-43005014-43005958,
chr21-43006547-43007242,
chr21-43007563-43008111,
chr21-43008975-43009699,
chr21-43011079-43011547,
chr21-43012278-43013148,
chr21-43016030-43017256,
chr21-43018084-43019388,
chr21-43020175-43023005,
chr21-43023655-43024103,
chr21-43024487-43026869,
chr21-43027260-43028315,
chr21-43028717-43029018,
chr21-43029424-43030648,
chr21-43031865-43032624,
chr21-43033056-43033422,
chr21-43033645-43034830,
chr21-43036478-43039973,
chr21-43099852-43100255,
chr21-43104309-43104688,
chr21-43106709-43112150,
chr21-43112950-43113541,
chr21-43115966-43118415,
chr21-43167531-43179410,
chr21-43179782-43180289,
chr21-43180997-43181922,
chr21-43186619-43189146,
chr21-43189488-43189736,
chr21-43190641-43195980,
chr21-43196363-43198075,
chr21-43202414-43202849,
chr21-43203180-43204296,
chr21-43205526-43206063,
chr21-43206324-43207655,
chr21-43207866-43208349,
chr21-43208557-43212285,
chr21-43265406-43280154,
chr21-43280924-43283710,
chr21-43285633-43286421,
chr21-43287064-43289808,
chr21-43290025-43293553,
chr21-43294387-43294818,
chr21-43295496-43295735,
chr21-43296982-43309547,
chr21-43311036-43327583,
chr21-43328508-43351938,
chr21-43352261-43357227,
chr21-43357471-43370764,
chr21-43371758-43372139,
chr21-43372411-43378616,
chr21-43574497-43576116,
chr21-43576516-43576782,
chr21-43578473-43579527,
chr21-43581013-43581404,
chr21-43581641-43582576,
chr21-43582859-43583337,
chr21-43583553-43584232,
chr21-43584938-43588325,
chr21-43589018-43591020,
chr21-43591407-43592525,
chr21-43592960-43594483,
chr21-43595004-43602071,
chr21-43602287-43614768,
chr21-43616172-43617037,
chr21-43618660-43619178,
chr21-43619389-43620762,
chr21-43621197-43621495,
chr21-43624303-43624805,
chr21-43626450-43626836,
chr21-43627385-43627862,
chr21-43631250-43632687,
chr21-43634076-43634294,
chr21-43634658-43635007,
chr21-43635772-43636021,
chr21-43636596-43637015,
chr21-43638930-43640728,
chr21-43640994-43641471,
chr21-43642814-43643056,
chr21-43643270-43649915,
chr21-43650183-43650609,
chr21-43652784-43653261,
chr21-43653524-43654073,
chr21-43654592-43655821,
chr21-43657025-43661637,
chr21-43663113-43663746,
chr21-43665582-43666779,
chr21-43667345-43668735,
chr21-43669130-43669692,
chr21-43669978-43670612,
chr21-43671144-43671960,
chr21-43672190-43672490,
chr21-43673349-43673603,
chr21-43675087-43675363,
chr21-43676274-43676773,
chr21-43680040-43680760,
chr21-43680996-43681953,
chr21-43682266-43682785,
chr21-43683749-43684802,
chr21-43686488-43690745,
chr21-43691074-43692529,
chr21-43692796-43693611,
chr21-43693964-43694960,
chr21-43696123-43696928,
chr21-43697136-43699761,
chr21-43699974-43701662,
chr21-43714967-43730833,
chr21-43731350-43745389,
chr21-43745728-43760952,
chr21-43761154-43780032,
chr21-43899414-43901125,
chr21-43902347-43902875,
chr21-43903389-43904929,
chr21-43905740-43906024,
chr21-43906608-43910716,
chr21-43911097-43912991,
chr21-43913332-43914290,
chr21-43914602-43914828,
chr21-43915079-43915725,
chr21-43916632-43919024,
chr21-43919860-43926811,
chr21-43971213-43978635,
chr21-43978988-43982273,
chr21-43982497-43984376,
chr21-43984827-43986234,
chr21-43986653-43987350,
chr21-43987624-43990156,
chr21-43991128-43996175,
chr21-43996484-43996757,
chr21-43997663-43998474,
chr21-43999790-44003430,
chr21-44024829-44026370,
chr21-44026684-44026973,
chr21-44027505-44027848,
chr21-44028245-44030150,
chr21-44030507-44031055,
chr21-44031429-44031975,
chr21-44032361-44032700,
chr21-44033569-44033850,
chr21-44034785-44035350,
chr21-44037935-44038524,
chr21-44038873-44039863,
chr21-44040458-44040984,
chr21-44041439-44041931,
chr21-44043223-44044061,
chr21-44044699-44045290,
chr21-44046465-44047576,
chr21-44048020-44048763,
chr21-44049059-44050644,
chr21-44051500-44052149,
chr21-44058034-44059019,
chr21-44060331-44060715,
chr21-44061133-44061570,
chr21-44062415-44062878,
chr21-44063088-44064391,
chr21-44065260-44065880,
chr21-44066159-44066445,
chr21-44067082-44068169,
chr21-44069413-44070104,
chr21-44070382-44070916,
chr21-44071581-44073072,
chr21-44074197-44074929,
chr21-44077348-44077570,
chr21-44078553-44078867,
chr21-44079138-44079687,
chr21-44081500-44084368,
chr21-44084897-44085581,
chr21-44086043-44086366,
chr21-44086762-44089972,
chr21-44090357-44091197,
chr21-44093882-44094111,
chr21-44094969-44096191,
chr21-44244978-44251442,
chr21-44251673-44252226,
chr21-44252559-44252895,
chr21-44253503-44259739,
chr21-44260974-44262029,
chr21-44262549-44268928,
chr21-44270131-44273478,
chr21-44273834-44274503,
chr21-44274897-44275317,
chr21-44320741-44336654,
chr21-44337821-44343795,
chr21-44344069-44346159,
chr21-44347920-44356379,
chr21-44498019-44500523,
chr21-44501160-44501716,
chr21-44502563-44504881,
chr21-44505123-44507485,
chr21-44507767-44517880,
chr21-44518230-44523339,
chr21-44523567-44524569,
chr21-44524891-44530101,
chr21-44799103-44805501,
chr21-44806825-44807985,
chr21-44808233-44808856,
chr21-44809850-44811758,
chr21-44812135-44814175,
chr21-44814747-44820942,
chr21-44823998-44825617,
-
Co-expression with cohesin genes Rho = 0.7034
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.321
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.865
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: IMR-90,TAMR-MCF7,MB157,Keratinocytes192627,H1-Mesenchymal,H1-Mesendoderm,Olfactory,MCF-7,HEK293T,SARS-Cov2-olfactory,GM12878,K-562,A-549,CyT49-pancreatic,HFFc6,HeLa-S3,H1-Trophectoderm,H9-hESC,iPSC,Liver,REC-1,HCT-116,Hep-G2,H1-hESC,HCC1599,HT-1376,Motor-Neuron,U-937,HUES64,CyT49-hESC,HUVEC,HL-60,RT-112,CyT49-endoderm,Skin-Fibroblast,KBM-7,CyT49-Gut,CC-2551,HAP1,HFF-hTERT,MCF7-FASR
- Related loop:
chr21:10325000-10350000~~chr21:42950000-42975000,
chr21:27500000-27525000~~chr21:43000000-43025000,
chr21:34350000-34375000~~chr21:42975000-43000000,
chr21:39625000-39650000~~chr21:42975000-43000000,
chr21:41650000-41675000~~chr21:43000000-43025000,
chr21:42050000-42075000~~chr21:42975000-43000000,
chr21:42550000-42575000~~chr21:43000000-43025000,
chr21:42575000-42600000~~chr21:42950000-42975000,
chr21:42575000-42600000~~chr21:43000000-43025000,
chr21:42600000-42625000~~chr21:43025000-43050000,
chr21:42625000-42650000~~chr21:43000000-43025000,
chr21:42650000-42675000~~chr21:43000000-43025000,
chr21:42675000-42700000~~chr21:43000000-43025000,
chr21:42675000-42700000~~chr21:43025000-43050000,
chr21:42900000-42925000~~chr21:43000000-43025000,
chr21:42900000-42925000~~chr21:43025000-43050000,
chr21:42925000-42950000~~chr21:43025000-43050000,
chr21:42950000-42975000~~chr21:43175000-43200000,
chr21:42950000-42975000~~chr21:43200000-43225000,
chr21:42950000-42975000~~chr21:43275000-43300000,
chr21:42950000-42975000~~chr21:43300000-43325000,
chr21:42950000-42975000~~chr21:43750000-43775000,
chr21:42954675-42957047~~chr21:42973040-42976308,
chr21:42974806-42976955~~chr21:42996600-42998372,
chr21:42975000-43000000~~chr21:43325000-43350000,
chr21:42975000-43000000~~chr21:43350000-43375000,
chr21:42975000-43000000~~chr21:43575000-43600000,
chr21:42975000-43000000~~chr21:43650000-43675000,
chr21:42975000-43000000~~chr21:44250000-44275000,
chr21:42975000-43000000~~chr21:44325000-44350000,
chr21:42975000-43000000~~chr21:44800000-44825000,
chr21:43000000-43025000~~chr21:43100000-43125000,
chr21:43000000-43025000~~chr21:43175000-43200000,
chr21:43000000-43025000~~chr21:43200000-43225000,
chr21:43000000-43025000~~chr21:43275000-43300000,
chr21:43000000-43025000~~chr21:43300000-43325000,
chr21:43000000-43025000~~chr21:43325000-43350000,
chr21:43000000-43025000~~chr21:43350000-43375000,
chr21:43000000-43025000~~chr21:43575000-43600000,
chr21:43000000-43025000~~chr21:43600000-43625000,
chr21:43000000-43025000~~chr21:43625000-43650000,
chr21:43000000-43025000~~chr21:43650000-43675000,
chr21:43000000-43025000~~chr21:43675000-43700000,
chr21:43000000-43025000~~chr21:43900000-43925000,
chr21:43000000-43025000~~chr21:43975000-44000000,
chr21:43000000-43025000~~chr21:44025000-44050000,
chr21:43000000-43025000~~chr21:44050000-44075000,
chr21:43000000-43025000~~chr21:44075000-44100000,
chr21:43025000-43050000~~chr21:43175000-43200000,
chr21:43025000-43050000~~chr21:43300000-43325000,
chr21:43025000-43050000~~chr21:43350000-43375000,
chr21:43025000-43050000~~chr21:43650000-43675000,
chr21:43025000-43050000~~chr21:43725000-43750000,
chr21:43025000-43050000~~chr21:44075000-44100000,
chr21:43025000-43050000~~chr21:44500000-44525000,
chr21:6425000-6450000~~chr21:43000000-43025000,
chr21:6425000-6450000~~chr21:43025000-43050000,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFIQYQWPF5, GSE95015, GSE43070, 4DNFIDJ2JZ7Q, 4DNFITUOMFUQ, 4DNFIBN9K4V9, ENCSR852KQC, 4DNFIDSWKFF5, 4DNFIZ4F74QR, 4DNFI7H4II2V, 4DNFIEYQ5ZIR, 4DNFIREVU1Z5, 4DNFI9VXTBE2, 4DNFIKYXMF1E, 4DNFIWNNO89O, 4DNFIRKGMZRQ, GSE97394, 4DNFICEGAHRC, 4DNFIE8T8JZ8, 4DNFI1E6NJQJ, 4DNFI9YAVTI1, 4DNFI6XD6JAQ, 4DNFISPUVQHA, 4DNFIK61ILGM, GSE116872, ENCSR305RTT, 4DNFI7XAZNNQ, GSE105028, 4DNFIQWD8ZYD, 4DNFI3CFMRID, ENCSR662QKG, GSE118716, ENCSR499RVD, 4DNFIB7QTIMH, 4DNFISNGDB53, 4DNFIOX3BGNE, GSE155380, 4DNFIJWBWE41, 4DNFICSTCJQZ, 4DNFIIMZB6Y9, GSE52457, 4DNFIBT4EAKN, Direct, 4DNFIXWCLD4M, 4DNFIAS8LV1C, 4DNFIV56OFE3, 4DNFIX7H3CE2, ENCSR244BBG, 4DNFI9815EEJ, 4DNFI9ZWZ5BS, 4DNFI2J1ODWB, 4DNFIVJ3IIQL, 4DNFIQ2687RT, 4DNFIFLJLIS5, 4DNFIDBIEXI7, 4DNFIDZT7PR8, 4DNFIZGCA8AH, 4DNFIH7TH4MF, 4DNFI1CIGHYC, 4DNFIT96Z365, 4DNFIH2A7IKF, 4DNFIWZEN3FF, ENCSR194SRI, 4DNFIBRSIPE4, 4DNFIR8OU6QJ, 4DNFI5CGQ46V, 4DNFIE8E4ANZ, GSE120294, 4DNFIW8TIFI5, ENCSR410MDC, 4DNFIMEG1QIC, ENCSR732QOH, 4DNFIBM714BP, 4DNFIF2D3TL9, 4DNFIFHU75I5, 4DNFIYD8LO9Z, ENCSR123UVP, 4DNFIL9M97T2, 4DNFI3A3VYWU, ENCSR637QCS, 4DNFIM2BMJ33, GSE165038, 4DNFIALNLR78, 4DNFIYDBBSE3, 4DNFIEJEFCAM, 4DNFIQRTP7NM, ENCSR393LOP, GSE44267, 4DNFIPAF4PYT, 4DNFIE5TEYK7, 4DNFIJ8JKKWJ, 4DNFIFI6NIKJ, 4DNFIDKJFK2S, ENCSR933UZH, GSE58752, GSE116869, 4DNFI8649RQJ, GSE116875, 4DNFIMROE6N4, GSE108787, 4DNFI5SUHCGZ, ENCSR545YBD, 4DNFIILDWK8M, 4DNFIHKWIZ9T, 4DNFI6EIFUZI, 4DNFIBCIA62Q, 4DNFII6AN691, GSE131580, 4DNFIV239W4L, 4DNFIOUSETUP, 4DNFI6JJQKFJ, 4DNFI1UEG1HD, 4DNFI8JFOAJT, 4DNFIOCW5AEM, 4DNFIQVMVRP6, 4DNFI5LCW273, 4DNFIP71EWXC, 4DNFINEQY95T, 4DNFILIM6FDL, 4DNFIHN2QSMX, 4DNFII84FBKM, 4DNFIVSCH2CH
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: U2OS,SLK
- Cohesin-DEGs, number of studies: 4
- Cohesin-DEGs, study: GSE138937,GSE89799
- Cohesin-DEGs, subunit: CTCF,Rad21