Deatailed information for gene ENSG00000160200
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00010436
- Gene Symbol: CBS
- Ensembl ID: ENSG00000160200
-
Gene locus: chr21:43053190-43076378
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs
- Regulatory cohesin (double-evidenced):
chr21-42599440-42600439,
chr21-42601201-42601742,
chr21-42607142-42608454,
chr21-42609794-42610085,
chr21-42614071-42618253,
chr21-42618578-42619171,
chr21-42619649-42620219,
chr21-42620846-42621537,
chr21-42624120-42625917,
chr21-42676262-42677139,
chr21-42677464-42680918,
chr21-42681246-42681895,
chr21-42682647-42686811,
chr21-42687678-42689455,
chr21-42689874-42691124,
chr21-42692085-42693894,
chr21-42694195-42694540,
chr21-42695409-42697261,
chr21-42697642-42697964,
chr21-42698273-42698662,
chr21-42699236-42699751,
chr21-42898938-42900986,
chr21-42901231-42902142,
chr21-42903879-42905128,
chr21-42905606-42906786,
chr21-42908791-42909506,
chr21-42909724-42911164,
chr21-42912357-42914258,
chr21-42914488-42914837,
chr21-42915076-42915684,
chr21-42916003-42917086,
chr21-42917709-42919392,
chr21-42919813-42921376,
chr21-42921622-42928571,
chr21-42928933-42932902,
chr21-42933507-42933865,
chr21-42936506-42943558,
chr21-42948707-42949766,
chr21-43049093-43049369,
chr21-43049841-43050585,
chr21-43052482-43054916,
chr21-43055392-43055838,
chr21-43056729-43057676,
chr21-43058259-43059537,
chr21-43060414-43061051,
chr21-43061415-43063030,
chr21-43063281-43067025,
chr21-43067812-43068495,
chr21-43069144-43069393,
chr21-43069823-43070529,
chr21-43071868-43073746,
chr21-43074203-43077637,
chr21-43077861-43078542,
chr21-43079407-43080410,
chr21-43167531-43179410,
chr21-43179782-43180289,
chr21-43180997-43181922,
chr21-43186619-43189146,
chr21-43189488-43189736,
chr21-43190641-43195980,
chr21-43196363-43198075,
chr21-43296982-43309547,
chr21-43311036-43327583,
chr21-43328508-43351938,
chr21-43352261-43357227,
chr21-43357471-43370764,
chr21-43371758-43372139,
chr21-43372411-43378616,
chr21-43650183-43650609,
chr21-43652784-43653261,
chr21-43653524-43654073,
chr21-43654592-43655821,
chr21-43657025-43661637,
chr21-43663113-43663746,
chr21-43665582-43666779,
chr21-43667345-43668735,
chr21-43669130-43669692,
chr21-43669978-43670612,
chr21-43671144-43671960,
chr21-43672190-43672490,
chr21-43673349-43673603,
chr21-43714967-43730833,
chr21-43731350-43745389,
chr21-43745728-43760952,
chr21-44077348-44077570,
chr21-44078553-44078867,
chr21-44079138-44079687,
chr21-44081500-44084368,
chr21-44084897-44085581,
chr21-44086043-44086366,
chr21-44086762-44089972,
chr21-44090357-44091197,
chr21-44093882-44094111,
chr21-44094969-44096191,
chr21-44498019-44500523,
chr21-44501160-44501716,
chr21-44502563-44504881,
chr21-44505123-44507485,
chr21-44507767-44517880,
chr21-44518230-44523339,
chr21-44523567-44524569,
chr21-44524891-44530101,
-
Co-expression with cohesin genes Rho = 0.2277
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.542
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.870
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: IMR-90,TAMR-MCF7,Keratinocytes192627,H1-Mesenchymal,Olfactory,MCF-7,HEK293T,SARS-Cov2-olfactory,GM12878,K-562,CyT49-pancreatic,HFFc6,HeLa-S3,H9-hESC,iPSC,HCT-116,Hep-G2,H1-hESC,HUVEC,CyT49-hESC,CyT49-endoderm,KBM-7,CyT49-Gut,CC-2551,HAP1,HFF-hTERT,MCF7-FASR
- Related loop:
chr21:42600000-42625000~~chr21:43025000-43050000,
chr21:42675000-42700000~~chr21:43025000-43050000,
chr21:42900000-42925000~~chr21:43025000-43050000,
chr21:42925000-42950000~~chr21:43025000-43050000,
chr21:43025000-43050000~~chr21:43175000-43200000,
chr21:43025000-43050000~~chr21:43300000-43325000,
chr21:43025000-43050000~~chr21:43350000-43375000,
chr21:43025000-43050000~~chr21:43650000-43675000,
chr21:43025000-43050000~~chr21:43725000-43750000,
chr21:43025000-43050000~~chr21:44075000-44100000,
chr21:43025000-43050000~~chr21:44500000-44525000,
chr21:6425000-6450000~~chr21:43025000-43050000,
chr21:6475000-6500000~~chr21:43075000-43100000,
- Cohesin-loop type: HiChIP,HiC,Direct
- Cohesin-loop study:
4DNFIQWD8ZYD, 4DNFI8649RQJ, 4DNFI3CFMRID, GSE43070, 4DNFIBRSIPE4, 4DNFIR8OU6QJ, 4DNFIDJ2JZ7Q, GSE118716, 4DNFIMROE6N4, 4DNFITUOMFUQ, GSE108787, 4DNFIB7QTIMH, 4DNFI5SUHCGZ, 4DNFISNGDB53, GSE120294, 4DNFIDSWKFF5, 4DNFIILDWK8M, 4DNFIZ4F74QR, 4DNFIHKWIZ9T, 4DNFIMEG1QIC, 4DNFIEYQ5ZIR, 4DNFI6EIFUZI, 4DNFIBM714BP, 4DNFIF2D3TL9, 4DNFIREVU1Z5, 4DNFI9VXTBE2, 4DNFIBCIA62Q, 4DNFIFHU75I5, 4DNFII6AN691, 4DNFIKYXMF1E, 4DNFIWNNO89O, 4DNFIYD8LO9Z, 4DNFICSTCJQZ, 4DNFICEGAHRC, 4DNFIIMZB6Y9, 4DNFIL9M97T2, 4DNFIE8T8JZ8, 4DNFI1E6NJQJ, 4DNFI9YAVTI1, 4DNFIBT4EAKN, GSE52457, 4DNFI3A3VYWU, Direct, 4DNFIALNLR78, 4DNFIH7TH4MF, 4DNFIAS8LV1C, 4DNFISPUVQHA, 4DNFI6JJQKFJ, 4DNFI1UEG1HD, 4DNFIV56OFE3, 4DNFIX7H3CE2, 4DNFIK61ILGM, 4DNFIYDBBSE3, 4DNFI8JFOAJT, 4DNFIQRTP7NM, GSE44267, 4DNFI9815EEJ, 4DNFIOCW5AEM, 4DNFIPAF4PYT, 4DNFI9ZWZ5BS, 4DNFI5LCW273, 4DNFI2J1ODWB, 4DNFI7XAZNNQ, 4DNFIP71EWXC, 4DNFIFLJLIS5, 4DNFILIM6FDL, 4DNFIDBIEXI7, 4DNFIQ2687RT, 4DNFIS5F6EBL, 4DNFIZGCA8AH, 4DNFIHN2QSMX, 4DNFI1CIGHYC, GSE105028, 4DNFII84FBKM, 4DNFIT96Z365, 4DNFIVSCH2CH
- Cohesin-loop subunit: Other,SMC1
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: HL-60,SLK,P3HR-1,K-562,MCF-10A,CMK,U2OS,HeLa,Keratinocytes
- Cohesin-DEGs, number of studies: 12
- Cohesin-DEGs, study: GSE83870,GSE140651,GSE131581,GSE71420,GSE154086,GSE131448,GSE138937,GSE89799
- Cohesin-DEGs, subunit: CTCF,Rad21,SA2,SMC1