Deatailed information for gene ENSG00000160209
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00010441
- Gene Symbol: PDXK
- Ensembl ID: ENSG00000160209
-
Gene locus: chr21:43719128-43762299
Strand: +
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs
- Regulatory cohesin (double-evidenced):
chr21-41750044-41752982,
chr21-41753429-41753815,
chr21-41754380-41755068,
chr21-41755301-41757502,
chr21-41758041-41771900,
chr21-41772125-41773546,
chr21-41774945-41781439,
chr21-42890204-42894569,
chr21-42955236-42958765,
chr21-42959015-42959246,
chr21-42959459-42961198,
chr21-42961474-42961813,
chr21-42962403-42962646,
chr21-42963590-42964529,
chr21-42965885-42969571,
chr21-42970561-42971027,
chr21-42971699-42976556,
chr21-43024487-43026869,
chr21-43027260-43028315,
chr21-43028717-43029018,
chr21-43029424-43030648,
chr21-43031865-43032624,
chr21-43033056-43033422,
chr21-43033645-43034830,
chr21-43036478-43039973,
chr21-43040304-43041198,
chr21-43041584-43043029,
chr21-43043372-43043773,
chr21-43044579-43047606,
chr21-43049093-43049369,
chr21-43049841-43050585,
chr21-43167531-43179410,
chr21-43179782-43180289,
chr21-43180997-43181922,
chr21-43186619-43189146,
chr21-43189488-43189736,
chr21-43190641-43195980,
chr21-43196363-43198075,
chr21-43202414-43202849,
chr21-43203180-43204296,
chr21-43205526-43206063,
chr21-43206324-43207655,
chr21-43207866-43208349,
chr21-43208557-43212285,
chr21-43296982-43309547,
chr21-43311036-43327583,
chr21-43328508-43351938,
chr21-43352261-43357227,
chr21-43357471-43370764,
chr21-43371758-43372139,
chr21-43372411-43378616,
chr21-43574497-43576116,
chr21-43576516-43576782,
chr21-43578473-43579527,
chr21-43581013-43581404,
chr21-43581641-43582576,
chr21-43582859-43583337,
chr21-43583553-43584232,
chr21-43584938-43588325,
chr21-43589018-43591020,
chr21-43591407-43592525,
chr21-43592960-43594483,
chr21-43595004-43602071,
chr21-43650183-43650609,
chr21-43652784-43653261,
chr21-43653524-43654073,
chr21-43654592-43655821,
chr21-43657025-43661637,
chr21-43663113-43663746,
chr21-43665582-43666779,
chr21-43667345-43668735,
chr21-43669130-43669692,
chr21-43669978-43670612,
chr21-43671144-43671960,
chr21-43672190-43672490,
chr21-43673349-43673603,
chr21-43713999-43714758,
chr21-43714967-43730833,
chr21-43731350-43745389,
chr21-43745728-43760952,
chr21-43761154-43780032,
chr21-43785556-43790918,
chr21-43849633-43862147,
chr21-43862655-43863537,
chr21-43863868-43868789,
chr21-43869455-43870414,
chr21-43871491-43871651,
chr21-43872321-43873703,
chr21-43874006-43875186,
chr21-43875610-43875942,
chr21-43876860-43877126,
chr21-43877444-43878583,
chr21-43878805-43881692,
chr21-43881940-43886603,
chr21-43887068-43887342,
chr21-43887684-43888899,
chr21-43890044-43891619,
chr21-43892018-43894317,
chr21-43895698-43896321,
chr21-43896892-43898172,
chr21-43898472-43898828,
chr21-43899414-43901125,
chr21-43919860-43926811,
chr21-43927637-43931258,
chr21-43931599-43933243,
chr21-43933573-43946204,
chr21-43946764-43947625,
chr21-43948082-43948523,
chr21-43949301-43950152,
chr21-43999790-44003430,
chr21-44003656-44007434,
chr21-44007816-44008392,
chr21-44008742-44009011,
chr21-44009756-44016003,
chr21-44016585-44017233,
chr21-44018250-44019461,
chr21-44019691-44020615,
chr21-44021146-44022462,
chr21-44022967-44023469,
chr21-44024829-44026370,
chr21-44244978-44251442,
chr21-44251673-44252226,
chr21-44252559-44252895,
chr21-44253503-44259739,
chr21-44260974-44262029,
chr21-44262549-44268928,
chr21-44270131-44273478,
chr21-44273834-44274503,
chr21-44274897-44275317,
chr21-44320741-44336654,
chr21-44337821-44343795,
chr21-44344069-44346159,
chr21-44347920-44356379,
chr21-44474734-44475102,
chr21-44477225-44484621,
chr21-44484854-44488529,
chr21-44488757-44489043,
chr21-44489948-44491135,
chr21-44493207-44494864,
chr21-44495074-44495354,
chr21-44496153-44497242,
chr21-44498019-44500523,
-
Co-expression with cohesin genes Rho = 0.3195
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.320
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.821
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: TAMR-MCF7,H1-Mesenchymal,MCF-7,HEK293T,GM12878,K-562,A-549,HeLa-S3,H9-hESC,Liver,H1-hESC,HT-1376,GM19238,NaiveB,U-937,NPC-H9,KBM-7,HFF-hTERT,MCF7-FASR
- Related loop:
chr21:41750000-41775000~~chr21:43750000-43775000,
chr21:42892194-42894528~~chr21:43717961-43720857,
chr21:42950000-42975000~~chr21:43750000-43775000,
chr21:43025000-43050000~~chr21:43725000-43750000,
chr21:43175000-43200000~~chr21:43725000-43750000,
chr21:43175000-43200000~~chr21:43750000-43775000,
chr21:43200000-43225000~~chr21:43750000-43775000,
chr21:43300000-43325000~~chr21:43750000-43775000,
chr21:43350000-43375000~~chr21:43700000-43725000,
chr21:43350000-43375000~~chr21:43725000-43750000,
chr21:43350000-43375000~~chr21:43750000-43775000,
chr21:43575000-43600000~~chr21:43725000-43750000,
chr21:43650000-43675000~~chr21:43750000-43775000,
chr21:43700000-43725000~~chr21:43925000-43950000,
chr21:43717830-43720923~~chr21:43788650-43790245,
chr21:43718134-43720810~~chr21:43788562-43790300,
chr21:43727794-43729810~~chr21:43775194-43777378,
chr21:43727966-43729871~~chr21:43788671-43790700,
chr21:43750000-43775000~~chr21:43850000-43875000,
chr21:43750000-43775000~~chr21:43875000-43900000,
chr21:43750000-43775000~~chr21:44000000-44025000,
chr21:43750000-43775000~~chr21:44250000-44275000,
chr21:43750000-43775000~~chr21:44325000-44350000,
chr21:43750000-43775000~~chr21:44475000-44500000,
chr21:6550000-6575000~~chr21:43725000-43750000,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFIWZEN3FF, GSE118716, ENCSR499RVD, GSE108787, GSE84022, ENCSR587DSF, 4DNFIIMZB6Y9, GSE52457, Direct, GSE165038, 4DNFISPUVQHA, 4DNFI1UEG1HD, GSE44267, 4DNFIPAF4PYT, ENCSR247RGI, ENCSR527RXH, ENCSR933UZH, 4DNFIDKJFK2S, 4DNFIDBIEXI7, GSE105028, GSE58752, 4DNFIT96Z365
- Cohesin-loop subunit: CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: HPC,OCI-AML-3,SLK,P3HR-1,CMK,CordBlood
- Cohesin-DEGs, number of studies: 6
- Cohesin-DEGs, study: GSE73224,GSE140651,GSE111537,GSE119828,GSE154086,GSE138937
- Cohesin-DEGs, subunit: SA2,CTCF,Rad21,SMC1,CdLS