Deatailed information for gene ENSG00000160223
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00010449
- Gene Symbol: ICOSLG
- Ensembl ID: ENSG00000160223
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Gene locus: chr21:44222990-44240945
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs
- Regulatory cohesin (double-evidenced):
chr21-44217470-44219027,
chr21-44219482-44221142,
chr21-44221938-44222627,
chr21-44222967-44224198,
chr21-44224978-44225434,
chr21-44225763-44226291,
chr21-44226650-44227251,
chr21-44227704-44228229,
chr21-44229795-44230171,
chr21-44230418-44231366,
chr21-44231801-44232049,
chr21-44233510-44233998,
chr21-44234418-44234633,
chr21-44235286-44235866,
chr21-44236759-44237538,
chr21-44237754-44244724,
chr21-44244978-44251442,
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Co-expression with cohesin genes Rho = 0.0516
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
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Gene expression across tissues (TPM):
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Tissue specificity of gene (Gini-coefficient): 0.425
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
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Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.880
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
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Involved cell types for loop evidence: HCT-116,KBM-7,H1-hESC,HAP1,HFFc6,Olfactory
- Related loop:
chr21:5025000-5050000~~chr21:44225000-44250000,
chr21:5050000-5075000~~chr21:44200000-44225000,
- Cohesin-loop type: HiC,Direct
- Cohesin-loop study:
4DNFI1E6NJQJ, 4DNFI6EIFUZI, 4DNFIBCIA62Q, Direct, 4DNFIP71EWXC, 4DNFI5SUHCGZ, 4DNFIJWBWE41, 4DNFIT96Z365, 4DNFIIMZB6Y9, 4DNFIQRTP7NM
- Cohesin-loop subunit: Other
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
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Involved cell types for DEG evidence: HCT116-mAID,HL-60,OCI-AML-3,P3HR-1,K-562,MCF-10A,CMK,U2OS
- Cohesin-DEGs, number of studies: 9
- Cohesin-DEGs, study: GSE140651,GSE111537,GSE101921,GSE131581,GSE154086,GSE131448,GSE106886,GSE89799
- Cohesin-DEGs, subunit: CTCF,SMC1,Rad21,SA2