Deatailed information for gene ENSG00000160255
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00010454
- Gene Symbol: ITGB2
- Ensembl ID: ENSG00000160255
-
Gene locus: chr21:44885952-44928873
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs
- Regulatory cohesin (double-evidenced):
chr21-43328508-43351938,
chr21-43352261-43357227,
chr21-43357471-43370764,
chr21-43371758-43372139,
chr21-43372411-43378616,
chr21-44077348-44077570,
chr21-44078553-44078867,
chr21-44079138-44079687,
chr21-44081500-44084368,
chr21-44084897-44085581,
chr21-44086043-44086366,
chr21-44086762-44089972,
chr21-44090357-44091197,
chr21-44093882-44094111,
chr21-44094969-44096191,
chr21-44320741-44336654,
chr21-44337821-44343795,
chr21-44344069-44346159,
chr21-44347920-44356379,
chr21-44474734-44475102,
chr21-44477225-44484621,
chr21-44484854-44488529,
chr21-44488757-44489043,
chr21-44489948-44491135,
chr21-44493207-44494864,
chr21-44495074-44495354,
chr21-44496153-44497242,
chr21-44498019-44500523,
chr21-44501160-44501716,
chr21-44502563-44504881,
chr21-44505123-44507485,
chr21-44507767-44517880,
chr21-44518230-44523339,
chr21-44523567-44524569,
chr21-44524891-44530101,
chr21-44648535-44651485,
chr21-44652014-44652466,
chr21-44652956-44653464,
chr21-44653790-44655119,
chr21-44655342-44656104,
chr21-44657623-44658306,
chr21-44658877-44659438,
chr21-44660721-44661286,
chr21-44661660-44661908,
chr21-44666337-44666984,
chr21-44669156-44669832,
chr21-44670503-44671575,
chr21-44672289-44672609,
chr21-44674682-44674829,
chr21-44699438-44700075,
chr21-44700276-44701276,
chr21-44701494-44705032,
chr21-44705399-44713548,
chr21-44716685-44716835,
chr21-44718430-44719031,
chr21-44721222-44721639,
chr21-44721934-44722192,
chr21-44723185-44724478,
chr21-44724719-44725397,
chr21-44770932-44775360,
chr21-44775568-44776159,
chr21-44778211-44780009,
chr21-44780867-44781685,
chr21-44784599-44786454,
chr21-44786700-44787596,
chr21-44788341-44788598,
chr21-44789666-44790323,
chr21-44791310-44795621,
chr21-44797363-44798119,
chr21-44799103-44805501,
chr21-44806825-44807985,
chr21-44808233-44808856,
chr21-44809850-44811758,
chr21-44812135-44814175,
chr21-44814747-44820942,
chr21-44823998-44825617,
chr21-44842094-44850066,
chr21-44862997-44876511,
chr21-44876848-44922035,
chr21-44922496-44936465,
chr21-44974593-45005352,
chr21-45124436-45132048,
chr21-45132786-45143934,
chr21-45145219-45145603,
chr21-45145953-45146151,
chr21-45147401-45149408,
chr21-45251073-45259845,
chr21-45261057-45263926,
chr21-45264207-45270973,
chr21-45276631-45278067,
chr21-45278276-45280924,
chr21-45281215-45285084,
chr21-45285295-45286241,
chr21-45286477-45297005,
chr21-45297393-45298845,
chr21-45299162-45312040,
chr21-45401908-45445613,
chr21-45447735-45461753,
chr21-45463590-45484721,
chr21-45799954-45801669,
chr21-45801901-45802870,
chr21-45803374-45804235,
chr21-45804566-45806380,
chr21-45809423-45809839,
chr21-45810206-45810279,
chr21-45811128-45811479,
chr21-45812475-45812693,
chr21-45813685-45816501,
chr21-45816934-45824027,
chr21-45824560-45825827,
chr21-45852342-45852716,
chr21-45852961-45853362,
chr21-45853877-45854268,
chr21-45854878-45855880,
chr21-45856638-45858073,
chr21-45859098-45862050,
chr21-45862690-45866808,
chr21-45867090-45872210,
chr21-45872497-45872737,
chr21-45873424-45874184,
chr21-45874401-45877128,
-
Co-expression with cohesin genes Rho = 0.2391
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.734
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.806
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: IMR-90,MCF-10A,TAMR-MCF7,MB157,DU145,Right-Ventricle,Aorta,GM12892,K1,Spleen,H1-Mesenchymal,H1-Mesendoderm,Olfactory,Hepatocyte-H9,GM19239,HEK293T,MCF-7,GM12891,SARS-Cov2-olfactory,GM12878,K-562,A-549,HFFc6,PAEC,HeLa-S3,LNCaP,H1-Trophectoderm,SU-DHL-2,H9-hESC,NCI-H1437,Liver,OCI-AML-3,HCT-116,Germinal-Center-B,Hep-G2,HT-1197,H1-hESC,HT-1376,GM19238,Motor-Neuron,MSLCL,NaiveB,GM19240,BMEC,SU-DHL-4,HUVEC,HL-60,RT-112,Skin-Fibroblast,Left-Ventricle,HFF-hTERT,HAP1,MCF7-FASR
- Related loop:
chr21:42825000-42850000~~chr21:44900000-44925000,
chr21:43350000-43375000~~chr21:44925000-44950000,
chr21:44075000-44100000~~chr21:44875000-44900000,
chr21:44325000-44350000~~chr21:44875000-44900000,
chr21:44325000-44350000~~chr21:44900000-44925000,
chr21:44325000-44350000~~chr21:44925000-44950000,
chr21:44475000-44500000~~chr21:44875000-44900000,
chr21:44475000-44500000~~chr21:44925000-44950000,
chr21:44500000-44525000~~chr21:44875000-44900000,
chr21:44500000-44525000~~chr21:44900000-44925000,
chr21:44500000-44525000~~chr21:44925000-44950000,
chr21:44509121-44511913~~chr21:44931981-44933531,
chr21:44509213-44512100~~chr21:44930976-44933923,
chr21:44509488-44511948~~chr21:44931870-44933936,
chr21:44509755-44512096~~chr21:44931884-44933752,
chr21:44509876-44511623~~chr21:44931107-44933966,
chr21:44650000-44675000~~chr21:44875000-44900000,
chr21:44700000-44725000~~chr21:44925000-44950000,
chr21:44775000-44800000~~chr21:44875000-44900000,
chr21:44775000-44800000~~chr21:44900000-44925000,
chr21:44775000-44800000~~chr21:44925000-44950000,
chr21:44799372-44802443~~chr21:44910613-44912668,
chr21:44799372-44802443~~chr21:44931965-44934113,
chr21:44799392-44802491~~chr21:44931992-44933524,
chr21:44799411-44802024~~chr21:44931881-44933864,
chr21:44799443-44802060~~chr21:44931925-44933520,
chr21:44799602-44802376~~chr21:44931909-44933980,
chr21:44799686-44802514~~chr21:44931456-44933916,
chr21:44799696-44802591~~chr21:44910581-44912708,
chr21:44799696-44802591~~chr21:44931870-44933936,
chr21:44799706-44802994~~chr21:44930823-44933918,
chr21:44800000-44825000~~chr21:44900000-44925000,
chr21:44800000-44825000~~chr21:44925000-44950000,
chr21:44800017-44802385~~chr21:44910606-44912868,
chr21:44800017-44802385~~chr21:44930976-44933923,
chr21:44800406-44801881~~chr21:44911198-44912387,
chr21:44800498-44802680~~chr21:44931107-44933966,
chr21:44800563-44802483~~chr21:44931469-44933956,
chr21:44800595-44801781~~chr21:44931962-44933491,
chr21:44845305-44846867~~chr21:44882190-44883389,
chr21:44845331-44847295~~chr21:44932164-44933556,
chr21:44869465-44870633~~chr21:44880328-44882150,
chr21:44875000-44900000~~chr21:44975000-45000000,
chr21:44875000-44900000~~chr21:45125000-45150000,
chr21:44891768-44894263~~chr21:44907505-44908846,
chr21:44891768-44894263~~chr21:44930785-44933706,
chr21:44891773-44894141~~chr21:44931965-44934113,
chr21:44891803-44894255~~chr21:44910606-44912868,
chr21:44891803-44894255~~chr21:44926388-44927791,
chr21:44891803-44894255~~chr21:44930976-44933923,
chr21:44892147-44893707~~chr21:44931469-44933956,
chr21:44892183-44893746~~chr21:44930823-44933918,
chr21:44892195-44893675~~chr21:44931107-44933966,
chr21:44892203-44893706~~chr21:44930883-44933881,
chr21:44892207-44893651~~chr21:44931448-44933890,
chr21:44892212-44893701~~chr21:44931746-44933965,
chr21:44892220-44893680~~chr21:44931733-44933993,
chr21:44892220-44893951~~chr21:44931456-44933916,
chr21:44892229-44894264~~chr21:44931870-44933936,
chr21:44892231-44894090~~chr21:44931809-44933956,
chr21:44892235-44894046~~chr21:44931900-44933734,
chr21:44892235-44894095~~chr21:44931820-44933527,
chr21:44892241-44893918~~chr21:44932118-44933457,
chr21:44892249-44894678~~chr21:44931725-44934224,
chr21:44892250-44893653~~chr21:44910602-44912703,
chr21:44892293-44893660~~chr21:44932028-44933568,
chr21:44892302-44893674~~chr21:44910602-44912573,
chr21:44892320-44893862~~chr21:44927581-44928821,
chr21:44911054-44912570~~chr21:44931107-44933966,
chr21:44914317-44915672~~chr21:44927526-44928979,
chr21:44925000-44950000~~chr21:45125000-45150000,
chr21:44925000-44950000~~chr21:45250000-45275000,
chr21:44925000-44950000~~chr21:45275000-45300000,
chr21:44925000-44950000~~chr21:45425000-45450000,
chr21:44925000-44950000~~chr21:45450000-45475000,
chr21:44925000-44950000~~chr21:45800000-45825000,
chr21:44925000-44950000~~chr21:45850000-45875000,
chr21:5100000-5125000~~chr21:44925000-44950000,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
GSE95015, GSE43070, 4DNFITUOMFUQ, ENCSR794RDS, 4DNFIBN9K4V9, ENCSR852KQC, 4DNFIZ4F74QR, 4DNFI7H4II2V, ENCSR350NJV, 4DNFIEYQ5ZIR, ENCSR113OIR, GSE99541, ENCSR668RDP, 4DNFIE8T8JZ8, 4DNFI1E6NJQJ, 4DNFI9YAVTI1, ENCSR658RQQ, ENCSR299VMZ, 4DNFISPUVQHA, GSE112000, 4DNFI8Y9SRP2, 4DNFIAWVDQ8C, ENCSR527RXH, GSE105028, ENCSR833CMG, 4DNFIBKZK63V, ENCSR033GUP, GSE87112, 4DNFI3CFMRID, ENCSR662QKG, GSE94872, GSE118716, ENCSR499RVD, GSE155380, 4DNFICSTCJQZ, ENCSR587DSF, ENCSR452NHL, GSE80820, GSE52457, Direct, ENCSR314HAC, ENCSR479MTN, 4DNFIYIAUEPW, ENCSR244BBG, 4DNFI9ZWZ5BS, 4DNFIVJ3IIQL, 4DNFIFLJLIS5, 4DNFIDBIEXI7, 4DNFIDZT7PR8, 4DNFIS5F6EBL, 4DNFIZGCA8AH, 4DNFIH7TH4MF, 4DNFIWZEN3FF, ENCSR194SRI, 4DNFIBRSIPE4, 4DNFI5CGQ46V, 4DNFIE8E4ANZ, GSE120294, GSE84022, ENCSR672RHL, 4DNFIW8TIFI5, ENCSR410MDC, ENCSR732QOH, 4DNFIBM714BP, 4DNFIF2D3TL9, 4DNFIYD8LO9Z, ENCSR444BAR, ENCSR123UVP, ENCSR550JLK, 4DNFI3A3VYWU, 4DNFIM2BMJ33, ENCSR386KHY, ENCSR379CII, 4DNFIEJEFCAM, ENCSR393LOP, GSE44267, 4DNFIPAF4PYT, GSE48592, 4DNFIDKJFK2S, ENCSR094EIC, ENCSR933UZH, GSE58752, ENCSR507AHE, GSE116869, 4DNFI8649RQJ, 4DNFIMROE6N4, GSE108787, 4DNFI5SUHCGZ, ENCSR545YBD, 4DNFIHKWIZ9T, 4DNFI6EIFUZI, GSE111537, GSE131580, ENCSR381DCY, ENCSR981FNA, 4DNFIV239W4L, ENCSR752QCX, ENCSR128RPG, 4DNFISTWNV9C, ENCSR312TUD, 4DNFI1UEG1HD, GSE101921, 4DNFIOCW5AEM, 4DNFIC3HAU11, 4DNFIQVMVRP6, ENCSR338WUS, 4DNFII84FBKM
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: HL-60,HPC,OCI-AML-3,SLK,K-562,MCF-10A,CMK,U2OS,Cortical-neuronal,Keratinocytes
- Cohesin-DEGs, number of studies: 18
- Cohesin-DEGs, study: GSE83870,GSE111537,GSE150118,GSE101921,GSE131581,GSE119828,GSE154086,GSE131448,GSE138937,GSE89799
- Cohesin-DEGs, subunit: SMC3,SA2,CTCF,SMC1,Rad21,SA1,CdLS