Deatailed information for gene ENSG00000160285
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00010459
- Gene Symbol: LSS
- Ensembl ID: ENSG00000160285
-
Gene locus: chr21:46188140-46228822
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-45316533-45338135,
chr21-45339035-45339421,
chr21-45340328-45340876,
chr21-45341176-45342108,
chr21-45342847-45354233,
chr21-45895276-45902934,
chr21-45905855-45907394,
chr21-45908410-45911399,
chr21-45911935-45913204,
chr21-45913451-45916964,
chr21-45917300-45917688,
chr21-45918949-45920374,
chr21-45921404-45925225,
chr21-45949436-45952197,
chr21-45953686-45954738,
chr21-45957735-45958770,
chr21-45959631-45960431,
chr21-45961061-45961698,
chr21-45961923-45962261,
chr21-45964738-45965740,
chr21-45966146-45976202,
chr21-46094789-46101183,
chr21-46101525-46102239,
chr21-46107500-46107764,
chr21-46108827-46114343,
chr21-46114890-46141044,
chr21-46141781-46148753,
chr21-46149160-46156934,
chr21-46179577-46186632,
chr21-46186833-46187560,
chr21-46187919-46196339,
chr21-46196677-46197088,
chr21-46197628-46197934,
chr21-46200854-46202398,
chr21-46202810-46203673,
chr21-46205119-46216728,
chr21-46217086-46221336,
chr21-46221787-46223056,
chr21-46223334-46230482,
chr21-46232833-46233302,
chr21-46252969-46258189,
chr21-46634382-46636748,
chr21-46638280-46640885,
-
Co-expression with cohesin genes Rho = 0.4663
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.243
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.778
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: HEK293T,GM12878,NPC-H9,IMR-90,K-562,H1-hESC,Motor-Neuron,HFF-hTERT,HFFc6,MCF7-FASR,SU-DHL-2,HeLa-S3,hTERT-HME1,H9-hESC,H1-Mesenchymal,H1-Mesendoderm
- Related loop:
chr21:36150000-36175000~~chr21:46175000-46200000,
chr21:44075000-44100000~~chr21:46175000-46200000,
chr21:45325000-45350000~~chr21:46200000-46225000,
chr21:45900000-45925000~~chr21:46200000-46225000,
chr21:45950000-45975000~~chr21:46200000-46225000,
chr21:46100000-46125000~~chr21:46200000-46225000,
chr21:46146852-46148242~~chr21:46209838-46211680,
chr21:46152443-46154288~~chr21:46209880-46211539,
chr21:46224712-46227816~~chr21:46256001-46257726,
chr21:46224751-46225933~~chr21:46639346-46640584,
chr21:46226574-46227839~~chr21:46635152-46636811,
- Cohesin-loop type: HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFI8649RQJ, 4DNFIWZEN3FF, GSE43070, 4DNFIMROE6N4, GSE118716, ENCSR852KQC, ENCSR410MDC, ENCSR866FWQ, 4DNFIBM714BP, 4DNFIIMZB6Y9, ENCSR128RPG, GSE52457, Direct, 4DNFIXWCLD4M, 4DNFI1UEG1HD, GSE44267, ENCSR991JXX, ENCSR247RGI, ENCSR338WUS, 4DNFIJ8JKKWJ, 4DNFIH7TH4MF
- Cohesin-loop subunit: Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: HL-60,HPC,OCI-AML-3,P3HR-1,K-562,HeLa-S3
- Cohesin-DEGs, number of studies: 6
- Cohesin-DEGs, study: GSE140651,GSE111537,GSE131581,GSE119828,GSE131448,GSE130558
- Cohesin-DEGs, subunit: CdLS,SMC1,WAPL,SA2