Deatailed information for gene ENSG00000160298
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00010462
- Gene Symbol: C21orf58
- Ensembl ID: ENSG00000160298
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Gene locus: chr21:46301129-46323875
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-46141781-46148753,
chr21-46284943-46285049,
chr21-46285330-46287984,
chr21-46289414-46300495,
chr21-46301269-46303301,
chr21-46303800-46304479,
chr21-46306249-46308643,
chr21-46308963-46309421,
chr21-46309644-46311180,
chr21-46311471-46312825,
chr21-46313333-46319898,
chr21-46320099-46321019,
chr21-46321556-46327387,
chr21-46327742-46329074,
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Co-expression with cohesin genes Rho = 0.4284
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
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Gene expression across tissues (TPM):
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Tissue specificity of gene (Gini-coefficient): 0.438
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
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Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.781
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
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Involved cell types for loop evidence: Skin-Fibroblast,Hep-G2,HT-1197,Kelly,H1-hESC,DU145,SU-DHL-2,PAEC,K1,hTERT-HME1,SU-DHL-4,Hepatocyte-H9
- Related loop:
chr21:46146626-46148368~~chr21:46324586-46327028,
chr21:46146642-46148386~~chr21:46324608-46326836,
chr21:46284828-46287850~~chr21:46324624-46326392,
chr21:46284891-46287117~~chr21:46325193-46327052,
chr21:46284913-46287579~~chr21:46323099-46326350,
chr21:46284994-46287562~~chr21:46323170-46326814,
chr21:46285004-46287523~~chr21:46324190-46326305,
chr21:46285202-46287572~~chr21:46324782-46326051,
chr21:46285204-46287304~~chr21:46324596-46326067,
chr21:46285206-46287083~~chr21:46324674-46326343,
chr21:46285212-46287543~~chr21:46321861-46326303,
chr21:46285216-46286892~~chr21:46324785-46326845,
chr21:46285222-46287087~~chr21:46324856-46327070,
chr21:46285272-46287549~~chr21:46324181-46326111,
- Cohesin-loop type: Direct,ChIAPET
- Cohesin-loop study:
ENCSR128RPG, ENCSR991JXX, ENCSR732QOH, ENCSR658RQQ, Direct, ENCSR314HAC, ENCSR668RDP, ENCSR381DCY, ENCSR386KHY, ENCSR146FPM, ENCSR672RHL, GSE103148, ENCSR587DSF
- Cohesin-loop subunit: SMC1,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
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Involved cell types for DEG evidence: MCF-7,P3HR-1,Kelly,U2OS,Keratinocytes
- Cohesin-DEGs, number of studies: 6
- Cohesin-DEGs, study: GSE115253,GSE83870,GSE140651,GSE177045,GSE89799
- Cohesin-DEGs, subunit: SMC1,Rad21,SMC3,BORIS