Deatailed information for gene ENSG00000173276
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00013477
- Gene Symbol: ZBTB21
- Ensembl ID: ENSG00000173276
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Gene locus: chr21:41986830-42010360
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-41600668-41607029,
chr21-41607264-41617134,
chr21-41617741-41618159,
chr21-41619036-41619135,
chr21-41620001-41623327,
chr21-41874717-41875401,
chr21-41876290-41881136,
chr21-41882621-41883088,
chr21-41883793-41886940,
chr21-41888988-41890386,
chr21-41891226-41891944,
chr21-41892186-41893065,
chr21-41893432-41894097,
chr21-41894414-41896406,
chr21-41896799-41898324,
chr21-41898621-41901470,
chr21-41951919-41960803,
chr21-41982603-41983049,
chr21-41985616-41986038,
chr21-41991035-41991464,
chr21-41992633-41992921,
chr21-41993548-41994398,
chr21-41995205-41996303,
chr21-42001760-42004907,
chr21-42005507-42006937,
chr21-42007533-42014157,
chr21-42053659-42066910,
chr21-42072432-42077357,
chr21-42077774-42087507,
chr21-42088172-42088785,
chr21-42089069-42090481,
chr21-42091730-42092368,
chr21-42092772-42095377,
chr21-42096641-42096982,
chr21-42097185-42102518,
chr21-42102731-42103045,
chr21-42103416-42126825,
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Co-expression with cohesin genes Rho = 0.5503
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
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Gene expression across tissues (TPM):
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Tissue specificity of gene (Gini-coefficient): 0.302
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
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Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.782
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
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Involved cell types for loop evidence: IMR-90,MB157,DU145,Olfactory,Hepatocyte-H9,MCF-7,SARS-Cov2-olfactory,K-562,HFFc6,HeLa-S3,SU-DHL-2,KU-19-19,H9-hESC,H1-hESC,HT-1376,NaiveB,SU-DHL-4,HUVEC,NPC-H9,CyT49-endoderm,RT-112,HFF-hTERT,HAP1
- Related loop:
chr21:41600000-41625000~~chr21:41975000-42000000,
chr21:41875000-41900000~~chr21:41975000-42000000,
chr21:41875000-41900000~~chr21:42000000-42025000,
chr21:41877545-41880451~~chr21:42008763-42011946,
chr21:41952495-41953705~~chr21:42008731-42011959,
chr21:41957072-41959223~~chr21:42008838-42011899,
chr21:41957418-41959149~~chr21:42008452-42012075,
chr21:41975000-42000000~~chr21:42075000-42100000,
chr21:42000000-42025000~~chr21:42100000-42125000,
chr21:42008409-42012026~~chr21:42106683-42108941,
chr21:42008452-42012075~~chr21:42106648-42108930,
chr21:42008727-42012041~~chr21:42106936-42108928,
chr21:42008728-42012071~~chr21:42106883-42109087,
chr21:42008730-42010862~~chr21:42116718-42118814,
chr21:42008738-42010602~~chr21:42116725-42118988,
chr21:42008738-42011645~~chr21:42106897-42108988,
chr21:42008738-42011645~~chr21:42116715-42119049,
chr21:42008738-42012043~~chr21:42106900-42108919,
chr21:42008744-42011714~~chr21:42060877-42064978,
chr21:42008744-42011714~~chr21:42106670-42109262,
chr21:42008744-42011714~~chr21:42116454-42119047,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
GSE95015, 4DNFIWZEN3FF, GSE43070, GSE94872, 4DNFIMROE6N4, GSE108787, 4DNFI5SUHCGZ, GSE84022, 4DNFIDSWKFF5, ENCSR672RHL, 4DNFI6EIFUZI, 4DNFIF2D3TL9, 4DNFIREVU1Z5, 4DNFIFHU75I5, 4DNFIRKGMZRQ, GSE99541, ENCSR381DCY, GSE155380, 4DNFIV239W4L, ENCSR587DSF, ENCSR128RPG, 4DNFISTWNV9C, ENCSR658RQQ, Direct, 4DNFIX7H3CE2, 4DNFIYDBBSE3, 4DNFIEJEFCAM, 4DNFIPAF4PYT, 4DNFIC3HAU11, ENCSR404HWQ, ENCSR247RGI, ENCSR933UZH, GSE105028, 4DNFIBKZK63V, GSE116869, 4DNFII84FBKM
- Cohesin-loop subunit: SMC1,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
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Involved cell types for DEG evidence: HL-60,HPC,SLK,P3HR-1,MCF-10A,U2OS,CordBlood
- Cohesin-DEGs, number of studies: 8
- Cohesin-DEGs, study: GSE73224,GSE140651,GSE101921,GSE131581,GSE119828,GSE138937,GSE89799
- Cohesin-DEGs, subunit: SA2,CTCF,SMC1,Rad21,SA1,CdLS