Deatailed information for gene ENSG00000182670
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00015288
- Gene Symbol: TTC3
- Ensembl ID: ENSG00000182670
-
Gene locus: chr21:37073270-37203103
Strand: +
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-36399798-36400258,
chr21-36400631-36402974,
chr21-36403437-36403958,
chr21-36404207-36404954,
chr21-36408129-36408499,
chr21-36411169-36411609,
chr21-36412195-36412659,
chr21-36413976-36414306,
chr21-36414631-36414945,
chr21-36415497-36416503,
chr21-36417281-36424270,
chr21-36424574-36425739,
chr21-36725682-36726362,
chr21-36726679-36728980,
chr21-36729274-36729976,
chr21-36730326-36734196,
chr21-36734513-36736672,
chr21-36737205-36737911,
chr21-36738247-36739054,
chr21-36739692-36739898,
chr21-36740699-36741157,
chr21-36741431-36742277,
chr21-36742878-36743515,
chr21-36744439-36745359,
chr21-36745702-36746410,
chr21-36747059-36748690,
chr21-36749881-36750694,
chr21-36938461-36938855,
chr21-36939198-36940146,
chr21-36953935-36954529,
chr21-36956521-36956982,
chr21-36957810-36958241,
chr21-36958523-36960338,
chr21-36962318-36962811,
chr21-36964520-36968171,
chr21-36969535-36969868,
chr21-36973649-36974411,
chr21-36974936-36975856,
chr21-36976322-36979183,
chr21-36980355-36981128,
chr21-36982411-36982979,
chr21-36983475-36983812,
chr21-36985242-36985787,
chr21-36986346-36986700,
chr21-36987033-36987211,
chr21-36987845-36988197,
chr21-36988629-36988824,
chr21-36989082-36991140,
chr21-36992148-36992448,
chr21-36992692-36993739,
chr21-36994195-36995191,
chr21-36996016-36996897,
chr21-36997444-36998032,
chr21-36999928-37001231,
chr21-37070631-37076219,
chr21-37076784-37077014,
chr21-37078520-37078699,
chr21-37079061-37080047,
chr21-37081855-37082126,
chr21-37082890-37083573,
chr21-37084687-37084979,
chr21-37085624-37086068,
chr21-37086511-37087720,
chr21-37089506-37089981,
chr21-37091613-37091912,
chr21-37093055-37093396,
chr21-37098838-37099047,
chr21-37101834-37102036,
chr21-37107876-37108085,
chr21-37109143-37109961,
chr21-37113198-37113379,
chr21-37117306-37117732,
chr21-37119296-37120160,
chr21-37126919-37127238,
chr21-37128168-37128386,
chr21-37131175-37131690,
chr21-37139577-37140371,
chr21-37140886-37141069,
chr21-37145513-37146764,
chr21-37149405-37149819,
chr21-37150896-37151160,
chr21-37152332-37152680,
chr21-37152964-37155737,
chr21-37159050-37159484,
chr21-37161265-37161843,
chr21-37164415-37164605,
chr21-37166246-37167761,
chr21-37169450-37169719,
chr21-37175142-37175597,
chr21-37176615-37177604,
chr21-37181038-37181527,
chr21-37184532-37185430,
chr21-37189251-37189761,
chr21-37191662-37192249,
chr21-37193059-37193458,
chr21-37194982-37195379,
chr21-37195645-37195983,
chr21-37196307-37196642,
chr21-37197105-37197434,
chr21-37197847-37198109,
chr21-37198943-37199970,
chr21-37200435-37201600,
chr21-37202328-37202527,
chr21-37206852-37210359,
chr21-37249994-37251771,
chr21-37254108-37254748,
chr21-37256946-37259141,
chr21-37259350-37259929,
chr21-37263577-37265365,
chr21-37265595-37269410,
chr21-37270551-37271438,
chr21-37271793-37272440,
chr21-37272945-37273597,
chr21-37274026-37274267,
chr21-37274761-37275372,
chr21-37275975-37276941,
chr21-37277329-37277713,
chr21-37277967-37278691,
chr21-37280983-37281425,
chr21-37281743-37283774,
chr21-37284037-37284878,
chr21-37285772-37286514,
chr21-37287818-37288055,
chr21-37288685-37289320,
chr21-37291072-37291768,
chr21-37294679-37295071,
chr21-37296857-37298781,
chr21-37299004-37300165,
chr21-37351226-37351559,
chr21-37352423-37352964,
chr21-37356357-37357538,
chr21-37357896-37359418,
chr21-37361494-37361790,
chr21-37362970-37363891,
chr21-37364688-37373796,
chr21-37374041-37376667,
chr21-37376938-37377779,
chr21-37378263-37379058,
chr21-37380008-37381186,
chr21-37383017-37383538,
chr21-37390571-37390871,
chr21-37393746-37394036,
chr21-37396832-37397053,
chr21-37425042-37425459,
chr21-37425733-37426027,
chr21-37427162-37427392,
chr21-37429469-37429659,
chr21-37430297-37430954,
chr21-37431347-37431604,
chr21-37432981-37433186,
chr21-37434876-37436804,
chr21-37437345-37438224,
chr21-37445166-37445721,
chr21-37446433-37447382,
chr21-37447585-37447850,
chr21-37449351-37449653,
chr21-37449911-37451094,
chr21-37451394-37453133,
chr21-37454218-37455770,
chr21-37456526-37456855,
chr21-37457092-37457603,
chr21-37458110-37460942,
chr21-37461967-37464126,
chr21-37465468-37465835,
chr21-37467127-37467422,
chr21-37468225-37468457,
chr21-37468762-37469282,
chr21-37469570-37470153,
chr21-37472439-37473360,
chr21-37474926-37475311,
chr21-37478789-37479291,
chr21-37479637-37479955,
chr21-37483561-37484153,
chr21-37485153-37485383,
chr21-37485921-37486191,
chr21-37489319-37490070,
chr21-37494670-37495794,
chr21-37496386-37498023,
chr21-37498550-37499117,
chr21-37501211-37501445,
chr21-37501854-37502204,
chr21-37503990-37504425,
chr21-37506066-37506334,
chr21-37507572-37508625,
chr21-37509446-37510263,
chr21-37510674-37510924,
chr21-37513898-37514561,
chr21-37517169-37518922,
chr21-37519283-37520043,
chr21-37520697-37520927,
chr21-37521747-37523668,
chr21-37527115-37527716,
chr21-37528156-37530049,
chr21-37530593-37532671,
chr21-37532943-37533875,
chr21-37534435-37535148,
chr21-37535724-37536412,
chr21-37536842-37537164,
chr21-37537415-37537884,
chr21-37538100-37538700,
chr21-37545632-37548152,
chr21-37548403-37549384,
chr21-37549977-37550331,
chr21-37550790-37553366,
chr21-37554097-37555011,
chr21-37555275-37556440,
chr21-37557099-37558213,
chr21-37558729-37559099,
chr21-37560348-37560783,
chr21-37562174-37566445,
chr21-37566898-37567476,
chr21-37567984-37568218,
chr21-37568432-37568753,
chr21-37573339-37573876,
chr21-37574240-37576121,
chr21-37580656-37583729,
chr21-37584556-37585034,
chr21-37586942-37587480,
chr21-37589421-37589947,
chr21-37590163-37590598,
chr21-37590864-37591234,
chr21-37591460-37591738,
chr21-37592031-37593523,
chr21-37593857-37595006,
chr21-37595795-37596355,
chr21-37597055-37597561,
chr21-37598275-37598568,
chr21-37625250-37626011,
chr21-37626527-37627532,
chr21-37631492-37632217,
chr21-37634872-37635580,
chr21-37636032-37637375,
chr21-37639797-37640540,
chr21-37641601-37643989,
chr21-37644571-37645342,
chr21-37646382-37647083,
chr21-37647564-37648424,
chr21-37649610-37650298,
chr21-37654485-37655372,
chr21-37655751-37657541,
chr21-37658435-37660876,
chr21-37661563-37661865,
chr21-37664785-37665141,
chr21-37665901-37666635,
chr21-37667425-37669249,
chr21-37670538-37671794,
chr21-37673084-37677389,
chr21-37710382-37713905,
chr21-37904870-37905118,
chr21-37909356-37909603,
chr21-37909892-37910463,
chr21-37913354-37918438,
chr21-37920197-37920610,
chr21-37920872-37921888,
chr21-38151064-38151512,
chr21-38155827-38157030,
chr21-38157453-38161826,
chr21-38165622-38167121,
chr21-38167829-38173299,
chr21-38173632-38174464,
chr21-38318023-38329470,
chr21-38330143-38331639,
chr21-38333133-38335676,
chr21-38340163-38340503,
chr21-38341496-38342080,
chr21-38342637-38344955,
chr21-38348297-38360784,
chr21-38362993-38363357,
chr21-38365365-38365661,
-
Co-expression with cohesin genes Rho = 0.5555
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.274
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.883
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: IMR-90,MB157,DU145,Keratinocytes192627,GM12892,K1,hTERT-HME1,H1-Mesenchymal,H1-Mesendoderm,Hepatocyte-H9,MCF-7,HEK293T,GM12891,GM12878,K-562,A-549,HFFc6,PAEC,HeLa-S3,H1-Trophectoderm,H9-hESC,KU-19-19,NCI-H1437,REC-1,ARPE-19,Hep-G2,HT-1197,H1-hESC,HT-1376,Motor-Neuron,MSLCL,NaiveB,HUES64,SU-DHL-4,NPC-H9,RT-112,Skin-Fibroblast,HFF-hTERT,HAP1,MCF7-FASR
- Related loop:
chr21:33500000-33525000~~chr21:37150000-37175000,
chr21:34350000-34375000~~chr21:37050000-37075000,
chr21:34350000-34375000~~chr21:37200000-37225000,
chr21:36400000-36425000~~chr21:37075000-37100000,
chr21:36725000-36750000~~chr21:37050000-37075000,
chr21:36938850-36940337~~chr21:37086674-37088107,
chr21:36950000-36975000~~chr21:37050000-37075000,
chr21:36950000-36975000~~chr21:37075000-37100000,
chr21:36975000-37000000~~chr21:37075000-37100000,
chr21:36975000-37000000~~chr21:37200000-37225000,
chr21:36976114-36978430~~chr21:37086465-37088179,
chr21:36976280-36978448~~chr21:37078697-37080394,
chr21:36976280-36978448~~chr21:37086131-37087976,
chr21:36976394-36978416~~chr21:37086094-37088173,
chr21:36976402-36978434~~chr21:37086106-37088263,
chr21:36976404-36978374~~chr21:37086393-37088124,
chr21:36976407-36978411~~chr21:37086055-37088195,
chr21:36976414-36978490~~chr21:37118786-37120541,
chr21:36976416-36978177~~chr21:37079107-37080371,
chr21:36976420-36978417~~chr21:37086403-37088182,
chr21:36976426-36978435~~chr21:37086473-37087963,
chr21:36976427-36978248~~chr21:37086150-37088199,
chr21:36976430-36978401~~chr21:37086077-37088227,
chr21:36976435-36978463~~chr21:37086055-37088213,
chr21:36989121-36991424~~chr21:37071179-37074846,
chr21:36989316-36991217~~chr21:37086306-37088100,
chr21:36999877-37001750~~chr21:37078770-37080416,
chr21:36999885-37001435~~chr21:37078647-37080436,
chr21:36999930-37001432~~chr21:37078697-37080394,
chr21:36999934-37001381~~chr21:37086150-37088199,
chr21:37050000-37075000~~chr21:37250000-37275000,
chr21:37050000-37075000~~chr21:37525000-37550000,
chr21:37078878-37080096~~chr21:37582024-37583384,
chr21:37118796-37120506~~chr21:37641349-37644042,
chr21:37150000-37175000~~chr21:37250000-37275000,
chr21:37150000-37175000~~chr21:37275000-37300000,
chr21:37150000-37175000~~chr21:37350000-37375000,
chr21:37150000-37175000~~chr21:37375000-37400000,
chr21:37150000-37175000~~chr21:37450000-37475000,
chr21:37150000-37175000~~chr21:37500000-37525000,
chr21:37150000-37175000~~chr21:37575000-37600000,
chr21:37150000-37175000~~chr21:37625000-37650000,
chr21:37150000-37175000~~chr21:37650000-37675000,
chr21:37150000-37175000~~chr21:37900000-37925000,
chr21:37150000-37175000~~chr21:38150000-38175000,
chr21:37150000-37175000~~chr21:38325000-38350000,
chr21:37150000-37175000~~chr21:38350000-38375000,
chr21:37165903-37167741~~chr21:37711396-37713035,
chr21:37165914-37167790~~chr21:37581870-37583744,
chr21:37165919-37167804~~chr21:37641816-37643880,
chr21:37165919-37167819~~chr21:37641580-37643713,
chr21:37165924-37167794~~chr21:37581806-37583572,
chr21:37165928-37167803~~chr21:37581799-37583709,
chr21:37165939-37167680~~chr21:37581819-37583687,
chr21:37165941-37167805~~chr21:37641570-37643772,
chr21:37165948-37167801~~chr21:37581734-37583636,
chr21:37165963-37167815~~chr21:37581749-37583648,
chr21:37165963-37167815~~chr21:37641599-37643616,
chr21:37166002-37167735~~chr21:37641416-37644157,
chr21:37166095-37167716~~chr21:37496458-37497998,
chr21:37166121-37167634~~chr21:37462553-37463976,
chr21:37166201-37167778~~chr21:37581833-37583520,
chr21:37166297-37167797~~chr21:37563454-37566884,
chr21:37175000-37200000~~chr21:37625000-37650000,
chr21:37200000-37225000~~chr21:37425000-37450000,
chr21:37200000-37225000~~chr21:37475000-37500000,
chr21:37200000-37225000~~chr21:37525000-37550000,
chr21:37200000-37225000~~chr21:37550000-37575000,
chr21:37200000-37225000~~chr21:37625000-37650000,
chr21:37200000-37225000~~chr21:37650000-37675000,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFI8649RQJ, 4DNFI3CFMRID, ENCSR662QKG, GSE95015, 4DNFIWZEN3FF, ENCSR194SRI, GSE43070, GSE116875, 4DNFIDJ2JZ7Q, GSE118716, 4DNFIE8E4ANZ, ENCSR499RVD, GSE108787, GSE116869, 4DNFI5SUHCGZ, ENCSR852KQC, GSE84022, GSE120294, ENCSR672RHL, 4DNFI7H4II2V, 4DNFIW8TIFI5, ENCSR410MDC, ENCSR350NJV, ENCSR732QOH, 4DNFIBM714BP, 4DNFIYD8LO9Z, ENCSR668RDP, ENCSR381DCY, GSE155380, ENCSR981FNA, 4DNFIV239W4L, GSE97394, 4DNFIL9M97T2, ENCSR452NHL, GSE52457, ENCSR658RQQ, 4DNFIM2BMJ33, ENCSR299VMZ, ENCSR314HAC, Direct, 4DNFI6XD6JAQ, 4DNFISPUVQHA, ENCSR386KHY, 4DNFI1UEG1HD, 4DNFI8Y9SRP2, GSE108869, 4DNFIYIAUEPW, ENCSR244BBG, GSE44267, ENCSR991JXX, 4DNFIQVMVRP6, GSE48592, ENCSR404HWQ, ENCSR247RGI, ENCSR110JOO, ENCSR338WUS, 4DNFI2J1ODWB, 4DNFIVJ3IIQL, 4DNFIJ8JKKWJ, 4DNFIDKJFK2S, ENCSR933UZH, ENCSR833CMG, 4DNFIDBIEXI7, 4DNFIDZT7PR8, GSE105028, 4DNFIHN2QSMX, 4DNFIH7TH4MF, ENCSR033GUP
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: HL-60,HPC,SLK,MCF-10A,Kelly,CMK,HeLa-S3
- Cohesin-DEGs, number of studies: 9
- Cohesin-DEGs, study: GSE115253,GSE101921,GSE131581,GSE119828,GSE154086,GSE138937,GSE108869,GSE130558
- Cohesin-DEGs, subunit: SA2,WAPL,CTCF,Rad21,BORIS,CdLS