Deatailed information for gene ENSG00000183486
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00015482
- Gene Symbol: MX2
- Ensembl ID: ENSG00000183486
-
Gene locus: chr21:41362026-41409393
Strand: +
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-40175731-40175912,
chr21-40176194-40177488,
chr21-40178811-40179473,
chr21-40182514-40183154,
chr21-40185278-40185741,
chr21-40186082-40186390,
chr21-40186622-40186984,
chr21-40187418-40188724,
chr21-40193864-40194947,
chr21-40932779-40933193,
chr21-40936639-40937196,
chr21-40947904-40948058,
chr21-41124570-41125247,
chr21-41125609-41125847,
chr21-41131071-41131294,
chr21-41132225-41137041,
chr21-41137303-41137741,
chr21-41138800-41139026,
chr21-41139502-41140501,
chr21-41140880-41142822,
chr21-41143510-41144226,
chr21-41146761-41148032,
chr21-41148592-41149430,
chr21-41149841-41150938,
chr21-41151775-41151894,
chr21-41153773-41154330,
chr21-41159227-41159964,
chr21-41165212-41165810,
chr21-41166931-41172082,
chr21-41173473-41173655,
chr21-41279309-41286918,
chr21-41287349-41287624,
chr21-41289470-41289790,
chr21-41290198-41290717,
chr21-41291671-41292309,
chr21-41295717-41296311,
chr21-41357146-41357972,
chr21-41358175-41363229,
chr21-41363511-41364777,
chr21-41365610-41366077,
chr21-41366312-41368581,
chr21-41368785-41370859,
chr21-41373113-41380866,
chr21-41381134-41381620,
chr21-41381847-41383678,
chr21-41386568-41386813,
chr21-41387809-41388751,
chr21-41388985-41389586,
chr21-41390040-41391268,
chr21-41392802-41395480,
chr21-41396219-41397986,
chr21-41399454-41400168,
chr21-41402087-41403104,
chr21-41403367-41403677,
chr21-41403964-41404378,
chr21-41404989-41406680,
chr21-41407263-41409410,
chr21-41409832-41412348,
chr21-41425596-41431302,
chr21-41442477-41454571,
chr21-41454845-41457031,
chr21-41457310-41463776,
chr21-41465279-41466074,
chr21-41466276-41469670,
chr21-41470417-41471816,
chr21-41472869-41473818,
chr21-41474341-41474869,
chr21-41499971-41502531,
chr21-41504215-41505004,
chr21-41505347-41509529,
chr21-41509897-41510115,
chr21-41510454-41511185,
chr21-41511910-41512243,
chr21-41512550-41513397,
chr21-41518109-41518579,
chr21-41520133-41522085,
chr21-41523158-41523411,
chr21-41524547-41525042,
chr21-41525661-41526249,
chr21-41526686-41527137,
chr21-41527940-41528857,
chr21-41529157-41529613,
chr21-41529914-41531492,
chr21-41531709-41531968,
chr21-41533651-41533917,
chr21-41535720-41537183,
chr21-41537437-41538094,
chr21-41539474-41540152,
chr21-41541451-41541829,
chr21-41544162-41544406,
chr21-41546008-41546302,
chr21-41547101-41547423,
chr21-41548755-41549570,
chr21-41576049-41576419,
chr21-41580516-41586056,
chr21-41588945-41589916,
chr21-41590736-41590940,
chr21-41591543-41591866,
chr21-41592562-41593315,
chr21-41596184-41596598,
chr21-41597407-41599450,
chr21-41600668-41607029,
chr21-41607264-41617134,
chr21-41617741-41618159,
chr21-41619036-41619135,
chr21-41620001-41623327,
chr21-41750044-41752982,
chr21-41753429-41753815,
chr21-41754380-41755068,
chr21-41755301-41757502,
chr21-41758041-41771900,
chr21-41772125-41773546,
chr21-41774945-41781439,
chr21-41850983-41851877,
chr21-41852110-41853345,
chr21-41853692-41855866,
chr21-41857229-41860002,
chr21-41861355-41866024,
chr21-41866387-41867228,
chr21-41867863-41869049,
chr21-41871292-41871941,
chr21-41872703-41874138,
chr21-41874717-41875401,
chr21-43202414-43202849,
chr21-43203180-43204296,
chr21-43205526-43206063,
chr21-43206324-43207655,
chr21-43207866-43208349,
chr21-43208557-43212285,
chr21-43328508-43351938,
chr21-43352261-43357227,
chr21-43357471-43370764,
chr21-43371758-43372139,
chr21-43372411-43378616,
-
Co-expression with cohesin genes Rho = 0.2430
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.608
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.871
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: MCF-7,NCI-H1437,GM12878,NPC-H9,Hep-G2,K-562,MCF-10A,TAMR-MCF7,H1-hESC,A-549,HFF-hTERT,MSLCL,SU-DHL-4,HeLa-S3,LNCaP,SU-DHL-2,H9-hESC,Hepatocyte-H9
- Related loop:
chr21:33400000-33425000~~chr21:41350000-41375000,
chr21:36525000-36550000~~chr21:41350000-41375000,
chr21:38775000-38800000~~chr21:41350000-41375000,
chr21:39175000-39200000~~chr21:41350000-41375000,
chr21:40175000-40200000~~chr21:41400000-41425000,
chr21:40925000-40950000~~chr21:41375000-41400000,
chr21:41125000-41150000~~chr21:41350000-41375000,
chr21:41150000-41175000~~chr21:41350000-41375000,
chr21:41169934-41171396~~chr21:41373764-41374984,
chr21:41275000-41300000~~chr21:41375000-41400000,
chr21:41282249-41284316~~chr21:41359432-41361272,
chr21:41282253-41284285~~chr21:41359487-41361156,
chr21:41282284-41284738~~chr21:41410569-41412490,
chr21:41282285-41284324~~chr21:41359525-41361220,
chr21:41282304-41284355~~chr21:41359414-41361284,
chr21:41282471-41284284~~chr21:41359635-41361174,
chr21:41282554-41284321~~chr21:41359636-41362143,
chr21:41350000-41375000~~chr21:41450000-41475000,
chr21:41350000-41375000~~chr21:41575000-41600000,
chr21:41350000-41375000~~chr21:41750000-41775000,
chr21:41350000-41375000~~chr21:41850000-41875000,
chr21:41350000-41375000~~chr21:43350000-43375000,
chr21:41361000-41363181~~chr21:41425246-41427778,
chr21:41367534-41370215~~chr21:41600536-41602815,
chr21:41368487-41370280~~chr21:41458627-41461687,
chr21:41368627-41370590~~chr21:41459655-41461711,
chr21:41368688-41370210~~chr21:41777426-41779194,
chr21:41368711-41370168~~chr21:41459737-41461655,
chr21:41368727-41370235~~chr21:41460007-41461704,
chr21:41375000-41400000~~chr21:41525000-41550000,
chr21:41375000-41400000~~chr21:43200000-43225000,
chr21:41400000-41425000~~chr21:41500000-41525000,
chr21:41400000-41425000~~chr21:41600000-41625000,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
GSE118716, ENCSR499RVD, GSE120294, ENCSR146FPM, 4DNFIZ4F74QR, 4DNFI7H4II2V, ENCSR410MDC, ENCSR113OIR, 4DNFII6AN691, ENCSR381DCY, ENCSR452NHL, ENCSR128RPG, 4DNFI9YAVTI1, 4DNFISTWNV9C, 4DNFIJ7OAIFQ, ENCSR658RQQ, 4DNFIM2BMJ33, Direct, 4DNFISPUVQHA, 4DNFIAS8LV1C, 4DNFI1UEG1HD, GSE101921, 4DNFIZF1KI43, ENCSR393LOP, ENCSR247RGI, ENCSR338WUS, GSE105028, ENCSR833CMG
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: SLK,OCI-AML-3,P3HR-1,K-562,MCF-10A,NUGC-3
- Cohesin-DEGs, number of studies: 11
- Cohesin-DEGs, study: GSE137253,GSE140651,GSE111537,GSE101921,GSE131448,GSE138937
- Cohesin-DEGs, subunit: NIPBL,SA2,CTCF,SMC1,Rad21