Deatailed information for gene ENSG00000184012
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00015620
- Gene Symbol: TMPRSS2
- Ensembl ID: ENSG00000184012
-
Gene locus: chr21:41466141-41531116
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction
- Regulatory cohesin (double-evidenced):
chr21-40127723-40128008,
chr21-40133778-40134486,
chr21-40137553-40137697,
chr21-40138649-40139119,
chr21-40139730-40140015,
chr21-40140942-40147745,
chr21-40149386-40149804,
chr21-41120392-41124044,
chr21-41124570-41125247,
chr21-41125609-41125847,
chr21-41131071-41131294,
chr21-41132225-41137041,
chr21-41137303-41137741,
chr21-41138800-41139026,
chr21-41139502-41140501,
chr21-41140880-41142822,
chr21-41143510-41144226,
chr21-41146761-41148032,
chr21-41148592-41149430,
chr21-41149841-41150938,
chr21-41151775-41151894,
chr21-41153773-41154330,
chr21-41159227-41159964,
chr21-41165212-41165810,
chr21-41166931-41172082,
chr21-41173473-41173655,
chr21-41200720-41201085,
chr21-41203279-41204508,
chr21-41207311-41209537,
chr21-41213457-41213771,
chr21-41214800-41215219,
chr21-41216467-41217270,
chr21-41217596-41218016,
chr21-41218863-41219208,
chr21-41219451-41220069,
chr21-41221113-41223031,
chr21-41223341-41223563,
chr21-41224862-41225153,
chr21-41279309-41286918,
chr21-41287349-41287624,
chr21-41289470-41289790,
chr21-41290198-41290717,
chr21-41291671-41292309,
chr21-41295717-41296311,
chr21-41303650-41304823,
chr21-41310090-41310814,
chr21-41312700-41313050,
chr21-41315579-41317852,
chr21-41318233-41318586,
chr21-41319164-41319889,
chr21-41320310-41323824,
chr21-41349571-41350286,
chr21-41350528-41350953,
chr21-41351402-41351758,
chr21-41351961-41352359,
chr21-41355172-41355403,
chr21-41356031-41356141,
chr21-41357146-41357972,
chr21-41358175-41363229,
chr21-41363511-41364777,
chr21-41365610-41366077,
chr21-41366312-41368581,
chr21-41368785-41370859,
chr21-41373113-41380866,
chr21-41381134-41381620,
chr21-41381847-41383678,
chr21-41386568-41386813,
chr21-41387809-41388751,
chr21-41388985-41389586,
chr21-41390040-41391268,
chr21-41392802-41395480,
chr21-41396219-41397986,
chr21-41399454-41400168,
chr21-41402087-41403104,
chr21-41403367-41403677,
chr21-41403964-41404378,
chr21-41404989-41406680,
chr21-41407263-41409410,
chr21-41409832-41412348,
chr21-41418958-41421549,
chr21-41421909-41422277,
chr21-41422923-41423423,
chr21-41423769-41424317,
chr21-41425596-41431302,
chr21-41431562-41433383,
chr21-41433595-41438072,
chr21-41438421-41440223,
chr21-41440635-41442106,
chr21-41442477-41454571,
chr21-41457310-41463776,
chr21-41465279-41466074,
chr21-41466276-41469670,
chr21-41470417-41471816,
chr21-41472869-41473818,
chr21-41474341-41474869,
chr21-41475093-41475521,
chr21-41475833-41476575,
chr21-41477136-41478922,
chr21-41479819-41481047,
chr21-41483205-41483900,
chr21-41485034-41485162,
chr21-41485845-41487478,
chr21-41487871-41488521,
chr21-41489050-41489599,
chr21-41490680-41490994,
chr21-41491203-41491494,
chr21-41494116-41494784,
chr21-41497626-41497997,
chr21-41499328-41499739,
chr21-41499971-41502531,
chr21-41504215-41505004,
chr21-41505347-41509529,
chr21-41509897-41510115,
chr21-41510454-41511185,
chr21-41511910-41512243,
chr21-41512550-41513397,
chr21-41518109-41518579,
chr21-41520133-41522085,
chr21-41523158-41523411,
chr21-41524547-41525042,
chr21-41525661-41526249,
chr21-41526686-41527137,
chr21-41527940-41528857,
chr21-41529157-41529613,
chr21-41529914-41531492,
chr21-41531709-41531968,
chr21-41533651-41533917,
chr21-41535720-41537183,
chr21-41576049-41576419,
chr21-41580516-41586056,
chr21-41588945-41589916,
chr21-41590736-41590940,
chr21-41591543-41591866,
chr21-41592562-41593315,
chr21-41596184-41596598,
chr21-41597407-41599450,
chr21-41600668-41607029,
chr21-41607264-41617134,
chr21-41617741-41618159,
chr21-41619036-41619135,
chr21-41620001-41623327,
chr21-41698776-41700406,
chr21-41701336-41702512,
chr21-41703830-41708250,
chr21-41710305-41711418,
chr21-41711706-41713056,
chr21-41713475-41714677,
chr21-41715027-41718311,
chr21-41719102-41720033,
chr21-41720825-41721220,
chr21-41721582-41723534,
chr21-41724219-41724820,
chr21-41750044-41752982,
chr21-41753429-41753815,
chr21-41754380-41755068,
chr21-41755301-41757502,
chr21-41758041-41771900,
chr21-41772125-41773546,
chr21-41774945-41781439,
chr21-41782169-41784881,
chr21-41785377-41785632,
chr21-41785969-41787549,
chr21-41793143-41793460,
chr21-41794325-41795136,
chr21-41796584-41797209,
chr21-41797596-41797844,
chr21-41798299-41798682,
chr21-41799784-41800050,
chr21-41823944-41825655,
chr21-41827924-41829367,
chr21-41830742-41836906,
chr21-41837774-41838052,
chr21-41838738-41839946,
chr21-41842489-41843082,
chr21-41844161-41847949,
chr21-41849107-41849386,
chr21-42097185-42102518,
chr21-42102731-42103045,
chr21-42103416-42126825,
chr21-42127155-42127810,
chr21-42128488-42129619,
chr21-42130648-42131154,
chr21-42133171-42133790,
chr21-42135118-42136218,
chr21-42136531-42136713,
chr21-42136966-42138370,
chr21-42139645-42142559,
chr21-42143139-42149312,
chr21-42149675-42151617,
chr21-42248295-42251114,
chr21-42251485-42252063,
chr21-42252355-42253740,
chr21-42254531-42254923,
chr21-42255135-42266245,
chr21-42267072-42268447,
chr21-42268710-42270140,
chr21-42271071-42271815,
chr21-42272186-42275483,
chr21-42275794-42277332,
chr21-42278585-42283213,
chr21-42283471-42284076,
chr21-42284283-42285457,
chr21-42285916-42288654,
chr21-42289750-42290327,
chr21-42290743-42296744,
chr21-42298296-42298540,
chr21-42299343-42300483,
chr21-42300983-42302568,
chr21-42302945-42303453,
chr21-42304539-42307451,
chr21-42307683-42313987,
chr21-42314400-42316186,
chr21-42316662-42318793,
chr21-42319099-42320523,
chr21-42320786-42322135,
chr21-43202414-43202849,
chr21-43203180-43204296,
chr21-43205526-43206063,
chr21-43206324-43207655,
chr21-43207866-43208349,
chr21-43208557-43212285,
-
Co-expression with cohesin genes Rho = 0.0273
FDR = 0.0004
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.843
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.875
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: MCF-10A,TAMR-MCF7,MB157,DU145,GM12892,K1,hTERT-HME1,H1-Mesenchymal,H1-Mesendoderm,Olfactory,Hepatocyte-H9,MCF-7,HEK293T,GM12891,SARS-Cov2-olfactory,GM12878,MSiPS,K-562,A-549,HFFc6,PAEC,HeLa-S3,SU-DHL-2,H9-hESC,NCI-H1437,Liver,ARPE-19,Hep-G2,H1-hESC,HCC1599,GM19238,HT-1376,MSLCL,SU-DHL-4,HUVEC,NPC-H9,RT-112,Skin-Fibroblast,Jurkat,CC-2551,HFF-hTERT,MCF7-FASR
- Related loop:
chr21:40125000-40150000~~chr21:41450000-41475000,
chr21:41121201-41122984~~chr21:41459735-41461936,
chr21:41121224-41122886~~chr21:41459709-41461697,
chr21:41121225-41122896~~chr21:41459683-41461603,
chr21:41121237-41123266~~chr21:41459580-41461716,
chr21:41121239-41122909~~chr21:41459867-41462122,
chr21:41121260-41122868~~chr21:41459775-41461692,
chr21:41121357-41122645~~chr21:41460157-41461407,
chr21:41125000-41150000~~chr21:41450000-41475000,
chr21:41150000-41175000~~chr21:41450000-41475000,
chr21:41200000-41225000~~chr21:41450000-41475000,
chr21:41275000-41300000~~chr21:41450000-41475000,
chr21:41275000-41300000~~chr21:41500000-41525000,
chr21:41275000-41300000~~chr21:41525000-41550000,
chr21:41281909-41284412~~chr21:41459991-41461684,
chr21:41282093-41284330~~chr21:41459685-41461551,
chr21:41282099-41284639~~chr21:41459664-41461786,
chr21:41282110-41284722~~chr21:41459434-41461559,
chr21:41282125-41284316~~chr21:41459620-41461739,
chr21:41282133-41284375~~chr21:41459735-41461936,
chr21:41282147-41284710~~chr21:41459580-41461716,
chr21:41282155-41284690~~chr21:41459307-41461849,
chr21:41282193-41284644~~chr21:41459685-41461836,
chr21:41282205-41284637~~chr21:41459476-41461719,
chr21:41282223-41284326~~chr21:41459674-41461814,
chr21:41282224-41284707~~chr21:41459487-41461757,
chr21:41282240-41284443~~chr21:41459800-41461731,
chr21:41282253-41284285~~chr21:41459934-41461665,
chr21:41282268-41284276~~chr21:41459775-41461692,
chr21:41282269-41284303~~chr21:41459918-41461732,
chr21:41282270-41284305~~chr21:41459683-41461603,
chr21:41282272-41284307~~chr21:41459825-41461718,
chr21:41282272-41284702~~chr21:41459656-41461660,
chr21:41282282-41284347~~chr21:41459502-41461722,
chr21:41282283-41284648~~chr21:41459867-41462122,
chr21:41282284-41284738~~chr21:41459709-41461697,
chr21:41282295-41284287~~chr21:41459726-41462162,
chr21:41282314-41285188~~chr21:41459631-41461654,
chr21:41282316-41284371~~chr21:41459776-41461623,
chr21:41282331-41284316~~chr21:41459997-41461595,
chr21:41282376-41284318~~chr21:41459958-41461683,
chr21:41282419-41284353~~chr21:41459674-41461670,
chr21:41282438-41284308~~chr21:41459812-41461705,
chr21:41282441-41284676~~chr21:41459795-41461716,
chr21:41282471-41284284~~chr21:41459737-41461655,
chr21:41282471-41284317~~chr21:41459729-41461718,
chr21:41282499-41284371~~chr21:41460072-41461492,
chr21:41300000-41325000~~chr21:41450000-41475000,
chr21:41300000-41325000~~chr21:41500000-41525000,
chr21:41350000-41375000~~chr21:41450000-41475000,
chr21:41368487-41370280~~chr21:41458627-41461687,
chr21:41368627-41370590~~chr21:41459655-41461711,
chr21:41368711-41370168~~chr21:41459737-41461655,
chr21:41368727-41370235~~chr21:41460007-41461704,
chr21:41375000-41400000~~chr21:41525000-41550000,
chr21:41400000-41425000~~chr21:41500000-41525000,
chr21:41425000-41450000~~chr21:41525000-41550000,
chr21:41450000-41475000~~chr21:41575000-41600000,
chr21:41450000-41475000~~chr21:41600000-41625000,
chr21:41450000-41475000~~chr21:41700000-41725000,
chr21:41450000-41475000~~chr21:41750000-41775000,
chr21:41450000-41475000~~chr21:41825000-41850000,
chr21:41450000-41475000~~chr21:42100000-42125000,
chr21:41450000-41475000~~chr21:42125000-42150000,
chr21:41450000-41475000~~chr21:42275000-42300000,
chr21:41500000-41525000~~chr21:41600000-41625000,
chr21:41500000-41525000~~chr21:41750000-41775000,
chr21:41500000-41525000~~chr21:41775000-41800000,
chr21:41500000-41525000~~chr21:42250000-42275000,
chr21:41500000-41525000~~chr21:42300000-42325000,
chr21:41525000-41550000~~chr21:43200000-43225000,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFIQWD8ZYD, 4DNFI8649RQJ, 4DNFIWZEN3FF, ENCSR194SRI, 4DNFIR8OU6QJ, GSE94872, 4DNFIDJ2JZ7Q, GSE118716, 4DNFIMROE6N4, ENCSR499RVD, GSE108787, 4DNFI5SUHCGZ, GSE120294, ENCSR361AYD, ENCSR672RHL, ENCSR146FPM, 4DNFIDSWKFF5, 4DNFI7H4II2V, ENCSR410MDC, 4DNFIMEG1QIC, ENCSR732QOH, 4DNFI6EIFUZI, 4DNFIA6NSSBJ, 4DNFIF2D3TL9, 4DNFIREVU1Z5, 4DNFIRKGMZRQ, GSE99541, ENCSR668RDP, ENCSR381DCY, 4DNFIHN2QSMX, GSE155380, 4DNFICSTCJQZ, ENCSR981FNA, ENCSR587DSF, ENCSR452NHL, 4DNFIOUSETUP, 4DNFIE8T8JZ8, GSE80820, ENCSR128RPG, 4DNFI9YAVTI1, 4DNFISTWNV9C, GSE52457, 4DNFIJ7OAIFQ, ENCSR658RQQ, 4DNFIM2BMJ33, 4DNFIX4PJKXZ, ENCSR299VMZ, ENCSR314HAC, Direct, 4DNFI6XD6JAQ, 4DNFIAS8LV1C, 4DNFISPUVQHA, 4DNFIX7H3CE2, 4DNFI1UEG1HD, GSE101921, 4DNFII84FBKM, 4DNFIYIAUEPW, ENCSR244BBG, GSE116872, 4DNFIZF1KI43, GSE44267, ENCSR991JXX, ENCSR778FXH, 4DNFIC3HAU11, ENCSR255XYX, ENCSR000FDB, ENCSR247RGI, ENCSR110JOO, ENCSR338WUS, 4DNFIQVMVRP6, 4DNFIFI6NIKJ, ENCSR527RXH, ENCSR933UZH, ENCSR833CMG, 4DNFIFLJLIS5, 4DNFIS5F6EBL, GSE105028, GSE58752, 4DNFIBKZK63V, GSE116869, ENCSR033GUP
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: False
-
Involved cell types for DEG evidence: U2OS,Kasumi-1
- Cohesin-DEGs, number of studies: 2
- Cohesin-DEGs, study: GSE89799,GSE47641
- Cohesin-DEGs, subunit: Rad21