Deatailed information for gene ENSG00000198743
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00017827
- Gene Symbol: SLC5A3
- Ensembl ID: ENSG00000198743
-
Gene locus: chr21:34073577-34106260
Strand: +
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-33525904-33526454,
chr21-33527092-33527653,
chr21-33529525-33530162,
chr21-33532796-33533465,
chr21-33533755-33533994,
chr21-33534392-33534803,
chr21-33535665-33535965,
chr21-33538818-33539084,
chr21-33539455-33539677,
chr21-33540381-33546238,
chr21-33546540-33546789,
chr21-33547026-33547321,
chr21-33547807-33548397,
chr21-33548736-33549040,
chr21-33549851-33553567,
chr21-33675259-33675593,
chr21-33678520-33679233,
chr21-33681669-33681950,
chr21-33682198-33684451,
chr21-33684696-33686775,
chr21-33687051-33688043,
chr21-33688329-33690064,
chr21-33690301-33691242,
chr21-33692275-33692558,
chr21-33693364-33693628,
chr21-33695730-33696319,
chr21-33700016-33700294,
chr21-33700936-33701037,
chr21-33701558-33702121,
chr21-33703645-33704316,
chr21-33704920-33705073,
chr21-33705365-33705686,
chr21-33706730-33707558,
chr21-33708388-33709548,
chr21-33711416-33711912,
chr21-33712966-33713558,
chr21-33713815-33714138,
chr21-33715952-33716503,
chr21-33717558-33717807,
chr21-33719132-33719441,
chr21-33723328-33723674,
chr21-33775163-33775433,
chr21-33778597-33778946,
chr21-33780702-33781002,
chr21-33781617-33781887,
chr21-33782467-33783022,
chr21-33783231-33783512,
chr21-33784205-33784483,
chr21-33789720-33790068,
chr21-33794698-33794955,
chr21-33795191-33795491,
chr21-33795906-33796270,
chr21-33798590-33800042,
chr21-33899805-33900206,
chr21-33901298-33903251,
chr21-33904131-33904969,
chr21-33913803-33916898,
chr21-33917462-33917726,
chr21-33918896-33919235,
chr21-33921048-33926629,
chr21-33930752-33933186,
chr21-33933885-33934098,
chr21-33934475-33934843,
chr21-33935976-33936727,
chr21-33936949-33938407,
chr21-33938778-33939105,
chr21-33939669-33941762,
chr21-33942492-33943155,
chr21-33944484-33945768,
chr21-33946584-33950682,
chr21-33951082-33952547,
chr21-33953313-33953520,
chr21-33956181-33956281,
chr21-33961186-33962466,
chr21-33963087-33963651,
chr21-33964274-33965220,
chr21-33966349-33970266,
chr21-33970541-33972949,
chr21-33973187-33974166,
chr21-33974402-33978652,
chr21-34070416-34071494,
chr21-34071705-34071912,
chr21-34072131-34076800,
chr21-34077159-34078441,
chr21-34078920-34079706,
chr21-34080088-34080383,
chr21-34082385-34083569,
chr21-34085588-34085895,
chr21-34086684-34087838,
chr21-34088093-34088654,
chr21-34089020-34089310,
chr21-34091155-34093003,
chr21-34094869-34095426,
chr21-34104657-34104885,
chr21-34105940-34106333,
chr21-34106889-34107301,
chr21-34108598-34109091,
chr21-34110152-34111183,
chr21-34178955-34179711,
chr21-34180822-34181533,
chr21-34183589-34183774,
chr21-34185182-34185546,
chr21-34185935-34187049,
chr21-34187656-34188698,
chr21-34189568-34191338,
chr21-34191993-34192521,
chr21-34194240-34194522,
chr21-34195280-34195731,
chr21-34196992-34197413,
chr21-34198106-34198720,
chr21-34199128-34205356,
chr21-34205572-34206804,
chr21-34207665-34207765,
chr21-34217743-34218130,
chr21-34219966-34220375,
chr21-34221388-34222210,
chr21-34222518-34224255,
chr21-34264956-34265232,
chr21-34269604-34269956,
chr21-34270378-34270876,
chr21-34271378-34273054,
chr21-34273641-34274038,
chr21-34330025-34330426,
chr21-34332972-34333971,
chr21-34334498-34338506,
chr21-34339763-34340385,
chr21-34340726-34341087,
chr21-34341939-34344393,
chr21-34344734-34353465,
chr21-34355390-34355626,
chr21-34356201-34356732,
chr21-34360486-34364137,
chr21-34364518-34364800,
chr21-34365500-34365847,
chr21-34366487-34368638,
chr21-34369248-34369608,
chr21-34371955-34372730,
chr21-34373717-34374267,
chr21-34374742-34376256,
chr21-34501761-34502015,
chr21-34504010-34504283,
chr21-34504884-34505791,
chr21-34506232-34507063,
chr21-34508107-34513689,
chr21-34514406-34516103,
chr21-34516659-34519824,
chr21-34520257-34523372,
chr21-34523800-34530931,
chr21-34598744-34600193,
chr21-34600852-34607197,
chr21-34607735-34607972,
chr21-34609310-34609958,
chr21-34610309-34610570,
chr21-34612457-34613145,
chr21-34613828-34615776,
chr21-34616709-34617250,
chr21-34618035-34618756,
chr21-34622856-34623945,
-
Co-expression with cohesin genes Rho = 0.5728
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.438
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.887
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: IMR-90,MCF-10A,MB157,Aorta,K1,H1-Mesenchymal,H1-Mesendoderm,Olfactory,Hepatocyte-H9,GM19239,HEK293T,MCF-7,SARS-Cov2-olfactory,GM12878,K-562,A-549,HFFc6,PAEC,HeLa-S3,H1-Trophectoderm,SU-DHL-2,H9-hESC,NCI-H1437,Liver,Hep-G2,H1-hESC,HT-1376,Motor-Neuron,NaiveB,HUES64,CyT49-hESC,NPC-H9,Left-Ventricle,CC-2551,HFF-hTERT,HAP1
- Related loop:
chr21:33525000-33550000~~chr21:34050000-34075000,
chr21:33675000-33700000~~chr21:34050000-34075000,
chr21:33700000-33725000~~chr21:34100000-34125000,
chr21:33775000-33800000~~chr21:34100000-34125000,
chr21:33900000-33925000~~chr21:34050000-34075000,
chr21:33900000-33925000~~chr21:34075000-34100000,
chr21:33900000-33925000~~chr21:34100000-34125000,
chr21:33922677-33925654~~chr21:34108278-34109481,
chr21:33922794-33925655~~chr21:34072307-34075130,
chr21:33922799-33925652~~chr21:34072055-34075610,
chr21:33923120-33925433~~chr21:34072467-34075245,
chr21:33923144-33925455~~chr21:34072248-34074599,
chr21:33923188-33925377~~chr21:34072259-34075558,
chr21:33925000-33950000~~chr21:34050000-34075000,
chr21:33925000-33950000~~chr21:34075000-34100000,
chr21:33931110-33932979~~chr21:34072676-34074842,
chr21:33946866-33949184~~chr21:34072307-34075130,
chr21:33950000-33975000~~chr21:34050000-34075000,
chr21:33967731-33970173~~chr21:34092084-34093399,
chr21:34050000-34075000~~chr21:34200000-34225000,
chr21:34050000-34075000~~chr21:34250000-34275000,
chr21:34050000-34075000~~chr21:34325000-34350000,
chr21:34050000-34075000~~chr21:34350000-34375000,
chr21:34050000-34075000~~chr21:34500000-34525000,
chr21:34050000-34075000~~chr21:34600000-34625000,
chr21:34072033-34075564~~chr21:34347215-34348903,
chr21:34072055-34075610~~chr21:34350835-34352930,
chr21:34072078-34075520~~chr21:34201046-34202955,
chr21:34072203-34075604~~chr21:34347152-34348883,
chr21:34072203-34075604~~chr21:34350950-34352712,
chr21:34072301-34075531~~chr21:34347428-34348867,
chr21:34072301-34075531~~chr21:34350864-34352907,
chr21:34072459-34075273~~chr21:34347146-34348894,
chr21:34073796-34075161~~chr21:34347195-34348845,
chr21:34075000-34100000~~chr21:34175000-34200000,
chr21:34075000-34100000~~chr21:34325000-34350000,
chr21:34100000-34125000~~chr21:34200000-34225000,
chr21:34100000-34125000~~chr21:34325000-34350000,
chr21:34100000-34125000~~chr21:34350000-34375000,
chr21:34100000-34125000~~chr21:34600000-34625000,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFI8649RQJ, 4DNFI3CFMRID, ENCSR662QKG, GSE95015, 4DNFIWZEN3FF, ENCSR194SRI, GSE43070, 4DNFI5CGQ46V, 4DNFIDJ2JZ7Q, 4DNFIE8E4ANZ, ENCSR499RVD, 4DNFIB7QTIMH, 4DNFIBN9K4V9, 4DNFI5SUHCGZ, GSE108787, GSE84022, GSE120294, 4DNFIOX3BGNE, 4DNFI7H4II2V, 4DNFIW8TIFI5, 4DNFIZ4F74QR, 4DNFIMEG1QIC, 4DNFIP25GZGA, 4DNFIBM714BP, 4DNFIF2D3TL9, 4DNFIA6NSSBJ, ENCSR866FWQ, 4DNFIKYXMF1E, 4DNFIYD8LO9Z, ENCSR668RDP, ENCSR381DCY, 4DNFIJWBWE41, ENCSR444BAR, GSE97394, ENCSR587DSF, 4DNFIIMZB6Y9, 4DNFIOUSETUP, 4DNFIE8T8JZ8, GSE80820, ENCSR128RPG, 4DNFI9YAVTI1, GSE52457, 4DNFIM2BMJ33, 4DNFIX4PJKXZ, Direct, ENCSR314HAC, ENCSR479MTN, 4DNFI6XD6JAQ, 4DNFIALNLR78, 4DNFISPUVQHA, 4DNFIX7H3CE2, GSE101921, GSE108869, 4DNFIEJEFCAM, ENCSR244BBG, ENCSR393LOP, GSE44267, 4DNFIOCW5AEM, 4DNFIPAF4PYT, 4DNFIQVMVRP6, ENCSR247RGI, ENCSR338WUS, 4DNFIVJ3IIQL, 4DNFIJ8JKKWJ, 4DNFIFI6NIKJ, 4DNFIDKJFK2S, ENCSR933UZH, ENCSR833CMG, 4DNFIDBIEXI7, 4DNFIDZT7PR8, GSE105028, GSE58752, 4DNFIBKZK63V, GSE116869, 4DNFII84FBKM
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: HCT116-mAID,HPC,SLK,P3HR-1,TC-32,MCF-10A,Kelly,HeLa-S3,CordBlood,NUGC-3
- Cohesin-DEGs, number of studies: 14
- Cohesin-DEGs, study: GSE115253,GSE137253,GSE140651,GSE111004,GSE74824,GSE101921,GSE119828,GSE138937,GSE106886,GSE108869,GSE130558
- Cohesin-DEGs, subunit: NIPBL,SA2,WAPL,CTCF,SMC1,Rad21,BORIS,SA1,CdLS