Deatailed information for gene ENSG00000241945
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00036121
- Gene Symbol: PWP2
- Ensembl ID: ENSG00000241945
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Gene locus: chr21:44107398-44131181
Strand: +
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs
- Regulatory cohesin (double-evidenced):
chr21-44106721-44108797,
chr21-44113185-44114709,
chr21-44119525-44120067,
chr21-44125194-44125764,
chr21-44127060-44127393,
chr21-44131339-44132312,
chr21-44132653-44134411,
chr21-44134730-44135728,
chr21-44274897-44275317,
chr21-44277399-44277711,
chr21-44278029-44278466,
chr21-44278794-44279072,
chr21-44279636-44308260,
chr21-44474734-44475102,
chr21-44477225-44484621,
chr21-44484854-44488529,
chr21-44488757-44489043,
chr21-44489948-44491135,
chr21-44493207-44494864,
chr21-44495074-44495354,
chr21-44496153-44497242,
chr21-44498019-44500523,
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Co-expression with cohesin genes Rho = 0.2298
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
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Gene expression across tissues (TPM):
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Tissue specificity of gene (Gini-coefficient): 0.312
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
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Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.786
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
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Involved cell types for loop evidence: HFFc6,SARS-Cov2-olfactory
- Related loop:
chr21:44125000-44150000~~chr21:44275000-44300000,
chr21:44125000-44150000~~chr21:44475000-44500000,
chr21:5100000-5125000~~chr21:44125000-44150000,
chr21:5150000-5175000~~chr21:44100000-44125000,
- Cohesin-loop type: HiC,Direct
- Cohesin-loop study:
Direct, 4DNFIMROE6N4, 4DNFIS5F6EBL, 4DNFI5SUHCGZ, 4DNFII84FBKM
- Cohesin-loop subunit: Other
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
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Involved cell types for DEG evidence: HCT116-mAID,HPC,OCI-AML-3,P3HR-1,Fibroblast,HAP1,iPSC-megakaryocytes,HeLa-S3
- Cohesin-DEGs, number of studies: 8
- Cohesin-DEGs, study: GSE140651,GSE111537,GSE119828,GSE126635,GSE106886,SRP050576,GSE130558
- Cohesin-DEGs, subunit: SA2,WAPL,CTCF,SMC1,Rad21,CdLS