Deatailed information for gene ENSG00000243646
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00036806
- Gene Symbol: IL10RB
- Ensembl ID: ENSG00000243646
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Gene locus: chr21:33266366-33297221
Strand: +
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-32377005-32377825,
chr21-32379033-32379799,
chr21-32381416-32385002,
chr21-32385478-32386069,
chr21-32386291-32386639,
chr21-32386870-32387447,
chr21-32388340-32390195,
chr21-32392163-32394318,
chr21-32394704-32394805,
chr21-32397459-32397677,
chr21-32450290-32453267,
chr21-32455431-32458336,
chr21-32458592-32459810,
chr21-32460801-32461622,
chr21-32462635-32464978,
chr21-32465888-32466157,
chr21-32467324-32467836,
chr21-32468636-32469297,
chr21-32470295-32471149,
chr21-32471386-32471935,
chr21-32472299-32473135,
chr21-32473670-32479773,
chr21-32824831-32828372,
chr21-32830402-32830634,
chr21-32831636-32833765,
chr21-32834854-32835342,
chr21-32836285-32836542,
chr21-32844499-32845578,
chr21-32846527-32846785,
chr21-32951208-32951430,
chr21-32955846-32956667,
chr21-32958326-32958988,
chr21-32961985-32962736,
chr21-32965025-32966085,
chr21-32968711-32969012,
chr21-32970880-32971243,
chr21-32973939-32974357,
chr21-33195338-33206151,
chr21-33206645-33209519,
chr21-33209798-33210131,
chr21-33211272-33213452,
chr21-33215011-33217335,
chr21-33219732-33220309,
chr21-33222873-33223242,
chr21-33224686-33226597,
chr21-33259241-33262524,
chr21-33263925-33265036,
chr21-33265360-33271071,
chr21-33271445-33271897,
chr21-33272560-33273289,
chr21-33278068-33278366,
chr21-33278760-33279199,
chr21-33279478-33279883,
chr21-33281091-33281795,
chr21-33282298-33282619,
chr21-33283111-33284448,
chr21-33285676-33297310,
chr21-33297831-33303232,
chr21-33346315-33351403,
chr21-33354048-33354418,
chr21-33355143-33356443,
chr21-33356778-33357973,
chr21-33359012-33364862,
chr21-33365781-33366490,
chr21-33367651-33369218,
chr21-33369612-33369909,
chr21-33370154-33370407,
chr21-33371268-33371854,
chr21-33372144-33385560,
chr21-34344734-34353465,
chr21-34355390-34355626,
chr21-34356201-34356732,
chr21-34360486-34364137,
chr21-34364518-34364800,
chr21-34365500-34365847,
chr21-34366487-34368638,
chr21-34369248-34369608,
chr21-34371955-34372730,
chr21-34373717-34374267,
chr21-34374742-34376256,
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Co-expression with cohesin genes Rho = 0.3295
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
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Gene expression across tissues (TPM):
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Tissue specificity of gene (Gini-coefficient): 0.358
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
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Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.835
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
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Involved cell types for loop evidence: MCF-7,GM12878,IMR-90,K-562,TAMR-MCF7,H1-hESC,HFF-hTERT,NaiveB,HFFc6,HeLa-S3,H9-hESC,H1-Mesenchymal,H1-Mesendoderm
- Related loop:
chr21:27500000-27525000~~chr21:33250000-33275000,
chr21:32375000-32400000~~chr21:33275000-33300000,
chr21:32450000-32475000~~chr21:33275000-33300000,
chr21:32825000-32850000~~chr21:33300000-33325000,
chr21:32950000-32975000~~chr21:33300000-33325000,
chr21:33200000-33225000~~chr21:33300000-33325000,
chr21:33250000-33275000~~chr21:33350000-33375000,
chr21:33275000-33300000~~chr21:34350000-34375000,
- Cohesin-loop type: HiChIP,HiC,Direct
- Cohesin-loop study:
4DNFIQYQWPF5, 4DNFI3CFMRID, GSE43070, 4DNFI5CGQ46V, 4DNFIMROE6N4, GSE118716, 4DNFIE8E4ANZ, GSE108787, 4DNFI5SUHCGZ, GSE84022, ENCSR410MDC, 4DNFIJWBWE41, 4DNFICEGAHRC, 4DNFIIMZB6Y9, GSE52457, Direct, 4DNFI1UEG1HD, 4DNFIPAF4PYT, 4DNFIQVMVRP6, GSE48592, 4DNFI2J1ODWB, 4DNFIVJ3IIQL, 4DNFIDKJFK2S, 4DNFIFLJLIS5, GSE105028
- Cohesin-loop subunit: Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
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Involved cell types for DEG evidence: SLK,U2OS,CMK,HAP1,CordBlood
- Cohesin-DEGs, number of studies: 6
- Cohesin-DEGs, study: GSE73224,GSE154086,GSE138937,GSE126635,GSE89799
- Cohesin-DEGs, subunit: CTCF,Rad21,SA2