Deatailed information for gene ENSG00000274276
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00052679
- Gene Symbol: CBSL
- Ensembl ID: ENSG00000274276
-
Gene locus: chr21:6444868-6468040
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs
- Regulatory cohesin (double-evidenced):
chr21-6440784-6441130,
chr21-6441518-6442187,
chr21-6444414-6446326,
chr21-6447704-6450884,
chr21-6451878-6452706,
chr21-6453818-6454548,
chr21-6455205-6458396,
chr21-6458961-6460146,
chr21-6460803-6462176,
chr21-6463584-6464022,
chr21-6464460-6464712,
chr21-6465038-6469241,
chr21-6469565-6469928,
chr21-6471054-6472059,
-
Co-expression with cohesin genes Rho = 0.1695
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.560
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.931
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: IMR-90,TAMR-MCF7,Keratinocytes192627,Olfactory,MCF-7,SARS-Cov2-olfactory,GM12878,K-562,CyT49-pancreatic,HFFc6,HeLa-S3,H9-hESC,iPSC,HCT-116,Hep-G2,H1-hESC,HUVEC,CyT49-hESC,CyT49-endoderm,KBM-7,CyT49-Gut,CC-2551,HAP1,HFF-hTERT,MCF7-FASR
- Related loop:
chr21:6425000-6450000~~chr21:42525000-42550000,
chr21:6425000-6450000~~chr21:42575000-42600000,
chr21:6425000-6450000~~chr21:42625000-42650000,
chr21:6425000-6450000~~chr21:42725000-42750000,
chr21:6425000-6450000~~chr21:42900000-42925000,
chr21:6425000-6450000~~chr21:43000000-43025000,
chr21:6425000-6450000~~chr21:43025000-43050000,
chr21:6425000-6450000~~chr21:43300000-43325000,
chr21:6425000-6450000~~chr21:43575000-43600000,
chr21:6425000-6450000~~chr21:43625000-43650000,
- Cohesin-loop type: HiChIP,HiC,Direct
- Cohesin-loop study:
4DNFIQWD8ZYD, 4DNFIQYQWPF5, 4DNFIBRSIPE4, 4DNFIR8OU6QJ, 4DNFI5CGQ46V, 4DNFIMROE6N4, GSE118716, 4DNFITUOMFUQ, 4DNFI5SUHCGZ, 4DNFISNGDB53, 4DNFIDSWKFF5, 4DNFIILDWK8M, 4DNFIOX3BGNE, 4DNFIZ4F74QR, ENCSR410MDC, 4DNFIHKWIZ9T, 4DNFIMEG1QIC, 4DNFIEYQ5ZIR, 4DNFI6EIFUZI, 4DNFIF2D3TL9, 4DNFIREVU1Z5, 4DNFIBCIA62Q, 4DNFI9VXTBE2, 4DNFIFHU75I5, 4DNFII6AN691, 4DNFIKYXMF1E, 4DNFIYD8LO9Z, 4DNFIJWBWE41, 4DNFICSTCJQZ, 4DNFICEGAHRC, 4DNFIIMZB6Y9, 4DNFIL9M97T2, 4DNFIE8T8JZ8, 4DNFI1E6NJQJ, 4DNFI9YAVTI1, 4DNFIBT4EAKN, 4DNFI3A3VYWU, Direct, 4DNFIALNLR78, 4DNFIH7TH4MF, 4DNFIAS8LV1C, 4DNFISPUVQHA, 4DNFI6JJQKFJ, 4DNFI1UEG1HD, 4DNFIV56OFE3, 4DNFIYDBBSE3, 4DNFIK61ILGM, 4DNFIEJEFCAM, 4DNFI8JFOAJT, 4DNFIQRTP7NM, 4DNFI9815EEJ, 4DNFIOCW5AEM, 4DNFI9ZWZ5BS, 4DNFI5LCW273, 4DNFI2J1ODWB, 4DNFI7XAZNNQ, 4DNFIJ8JKKWJ, 4DNFIP71EWXC, 4DNFIFLJLIS5, 4DNFILIM6FDL, 4DNFIDZT7PR8, 4DNFINEQY95T, 4DNFIQ2687RT, 4DNFIZGCA8AH, 4DNFIHN2QSMX, 4DNFI1CIGHYC, GSE105028, 4DNFII84FBKM, 4DNFIT96Z365, 4DNFIVSCH2CH
- Cohesin-loop subunit: Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: MCF-7,MCF-10A,HeLa-S3,P3HR-1
- Cohesin-DEGs, number of studies: 4
- Cohesin-DEGs, study: GSE140651,GSE177045,GSE101921,GSE130558
- Cohesin-DEGs, subunit: WAPL,CTCF,SMC1,Rad21