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Basic information

CohesinDB ID: CDBP00412866

Locus: chr21-10412733-10417199

Data sourse: GSE206145-GSE177045, GSE67783, GSE86191, GSE25021, GSE206145-NatGen2015, GSE62063, ENCSR153HNT, GSE83726, GSE131606, GSE50893, GSE145327, GSE38411

Cell type: MCF-7, Fibroblast, HCT-116, RH4, Ramos, DKO, HSPC, K-562, BCBL-1, GM18951, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 7% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.878

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 26% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "9_Het": 61%, "8_ZNF/Rpts": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: KDM4B, RBFOX2, SIN3B, ATF3, NFIC, THAP1, TRIM28, E2F5, RBM39, SMAD5, SAP30, ESR1, CTCF, TCF12, SND1, EP300, MNT, E2F6, TRIM24, E2F4, TEAD4, GTF2F1, TFAP2C, POU2F2, CHD8, MYCN, TBP, ERG, ASCL1, ETS1, MYC, RCOR1, NFRKB, NR3C1, EZH2, PHF8, ZHX2, HDAC2, ZNF644, TAF9B, HCFC1, EP400, NCOA2, ZC3H11A, NFYB, PTBP1, RUNX1, CBX1, SMC1A, HDAC1, SIN3A, ZFX, ZNF18, MYBL2, CREBBP, NRF1, ARNT, NFYA, NR2C1, FOS, SUPT5H, CHD1, MED1, PML, SMAD1, TAF7, C11orf30, L3MBTL2, SETDB1, SP1, PHF20, REST, RBM25, ZHX1, HNRNPLL, MBD2, SMC3, NFATC3, TRP47, CREM, CHD2, RBBP5, ZBED1, WT1, ZKSCAN1, ZNF589, YY1, RELA, TARDBP, NEUROD1, JUNB, CHAMP1, SP140, HIF1A, MGA, MAX, ZNF143, NCOA3, GFI1B, KDM5B, RBM14, KAT8, BHLHE40, AR, TAF1, ZBTB40, EGLN2, EGR1, BRD4, MAZ, MEF2D, ZZZ3

Target gene symbol (double-evidenced CRMs): TPTE

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 41

Related genes and loops

Related gene: ENSG00000274391,

eachgene

Deatailed information for cohesin site CDBP00412866