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Basic information

CohesinDB ID: CDBP00413238

Locus: chr21-14382340-14384384

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, GSE126634, GSE116868, ENCSR000BLY, ENCSR404BPV, ENCSR000ECS, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, GSE165895, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE152721, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE138105, GSE130135, ENCSR703TNG, GSE116344, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000EHW, GSE85526, GSE62063, GSE206145, ENCSR000EHX, ENCSR620NWG, GSE38395, ENCSR167MTG, GSE110061, GSE111913, GSE155324, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE50893, GSE126755, ENCSR748MVX, GSE64758

Cell type: RH4, GM10847, GM2610, SLK, GM19240, OCI-AML-3, HSPC, Liver, HuCC-T1, RPE, Fibroblast, HEKn, HeLa-S3, hLCL, GM2255, K-562, GM18486, HFFc6, H1-hESC, GM18951, SNYDER, Monocytes, MB157, Lymphoblast, GM12891, SK-N-SH, GM19239, RT-112, GM19193, Macrophage, Ramos, MCF-7, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, Neutrophil, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 22% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.544

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 46% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "2_TssAFlnk": 37%, "1_TssA": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, PAX5, TEAD1, LMO2, OCA2, MED26, PITX3, HDAC8, E4F1, ARID5B, SOX5, PAX8, E2F4, DEK, ZNF528, RFX3, KMT2B, GATAD2A, NANOG, POU5F1, BRD3, TOP2A, ZNF263, CTBP1, ZMYND11, DUX4, STAT1, ZNF563, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, FOXK2, UBN1, RCOR1, NR2F6, NFRKB, CD74, CEBPB, CREB1, DDX21, GABPB1, ZHX2, ELF4, MIXL1, ZNF257, GATA2, ZNF644, MXD3, FLI1, HCFC1, MXI1, DRAP1, NR2C2, RELB, EP400, RUNX1, HDAC1, CEBPA, NKX2-2, IRF3, PALB2, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, CBX4, TFDP1, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, TERF1, PIAS1, SMAD1, C11orf30, EVI1, GSPT2, IKZF5, ARID2, AFF1, MBD2, ELL2, NFATC3, ZNF207, CBX3, CREM, CHD2, PAF1, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, DEAF1, NEUROD1, JUNB, ZFP36, BATF, PLAG1, KLF4, BCL11B, ZBTB6, EGR2, ELF3, ARID4B, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, PBX2, ATF3, ZC3H8, ZFP64, RUNX3, CBFB, ZSCAN4, MITF, BACH2, ZNF467, MAF, JMJD1C, INTS11, ELF1, RBM39, SNAI2, KLF10, SMAD5, CTCF, TAF3, JUN, ZBTB20, MNT, LMO1, DPF2, SIX5, IRF4, DDX20, ZNF677, PDX1, TFAP2C, RBPJ, MLX, MTA2, ZBTB17, ZBTB48, NONO, SRF, NBN, PBX1, ONECUT1, KDM4A, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, ZKSCAN5, KDM5A, NFIL3, CC2D1A, THAP11, CTNNB1, ZNF585A, ZBTB24, LDB1, SOX13, AFF4, POU4F2, SP3, ARNT, BACH1, ZNF48, ZEB2, NFYA, HMBOX1, PBX3, HMGXB4, TEAD3, ZXDB, U2AF1, TAF7, KLF9, USF1, BCL11A, SP1, TFAP2A, NKX2-5, ATF7, ASH2L, CTBP2, GLIS2, SMC3, STAG1, MLLT1, ZNF394, AGO1, MTA3, EBF1, MAFF, ZNF580, ZKSCAN1, BCL3, KDM1A, ZNF441, KAT2B, ZIC2, PCGF1, GATA3, TAL1, ZNF143, MTA1, AGO2, TP53, ZNF334, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, BRD4, SPIN1, JUND, CUX1, ZFP42, PGR, SOX2, PATZ1, UBTF, TFAP4, SIN3B, ATF4, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, SND1, KLF1, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, SP4, TBP, HOXC5, SMARCC2, ETS1, MYC, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF786, ZNF202, PCBP1, HDAC2, RBP2, INTS13, NCOA2, ZNF76, ZNF554, NFYB, ETV5, BCL6, SIN3A, ZFP37, ERG3, MYBL2, CREBBP, ZNF384, RARA, NFYC, ZNF35, SMAD4, CDK8, ZEB1, SPDEF, NCOA1, SREBF2, MAFK, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF574, ZNF823, YY2, RELA, TARDBP, SKIL, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, T, AR, KMT2D, YAP1, ZNF324, HEXIM1, AHR, FOSL2, DMAP1, ZNF391, HMG20A, MEIS2, SUZ12, RBFOX2, ZFHX2, NFIC, ZNF362, CTCFL, PRDM1, MECOM, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, TCF12, EP300, BAF155, GATA6, SOX6, CREB3, E2F1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, CDK7, RUNX1T1, ID3, GATAD1, GMEB2, ARID3A, ZNF341, EOMES, RAD21, GRHL3, XRCC5, ZNF614, NFE2, ZNF667, ZNF639, ZNF750, TRPS1, TFE3, HBP1, IRF1, SREBF1, ZGPAT, MRTFB, MYF5, ATF1, PTBP1, SMC1A, CBX1, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, TWIST1, IRF2, PRPF4, NOTCH1, RUNX2, ZSCAN30, GATA4, CDK6, PBX4, NRF1, SUPT5H, CHD1, FOS, MED1, CEBPD, MYB, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, NIPBL, ZBTB7A, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, MIER2, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, SP140, HIF1A, OTX2, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF512, BHLHE40, NFKBIZ, TAF1, ZBTB40, NOTCH3, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): NRIP1,RBM11,USP25,HSPA13,SAMSN1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 34

Number of somatic mutations (non-coding): 12

Related genes and loops

Related gene: ENSG00000185272, ENSG00000155304, ENSG00000155307, ENSG00000180530, ENSG00000155313,

eachgene

Deatailed information for cohesin site CDBP00413238