- Basic information
- CohesinDB ID: CDBP00413263
- Locus: chr21-14530357-14536642
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Data sourse: GSE104888, GSE108869, GSE93080, ENCSR000EAC, ENCSR000DZP, GSE138405, GSE101921, GSE206145-NatGen2015, GSE120943, GSE98367, ENCSR879KXD, GSE206145, GSE62063, ENCSR000BMY, GSE38395, GSE129526, GSE155324, ENCSR000EDE, GSE68388, GSE126990, GSE50893, GSE126755, ENCSR000ECS
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Cell type: GM2610, HuCC-T1, B-cell, GM2630, HMEC, Fibroblast, HeLa-S3, hLCL, GM2255, K-562, SNYDER, Monocytes, GM18505, Lymphoblast, GM12878, GM12891, GM2588, GM19193, Macrophage, Ramos, GM12892, Hela-Kyoto, HCT-116, Neutrophil
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 9% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.733
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
41% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 37%,
"7_Enh": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, FOXA1, SUZ12, PBX2, UBTF, HDGF, ATF3, NFIC, ATF4, DPF1, MITF, JMJD1C, MAF, TEAD1, BCLAF1, TRIM28, OCA2, USF2, JUN, MNT, E2F6, TRIM24, RAD51, TEAD4, PDX1, EED, POU2F2, DUX4, ZBTB48, STAT1, NBN, ERG, MYC, SMARCA4, ARID1B, RAD21, GABPA, STAT3, NKX3-1, IKZF1, NR3C1, CEBPB, STAT5B, KMT2A, SPI1, IRF1, HDAC2, FLI1, RELB, MRTFB, RUNX1, BCL6, SMC1A, HDAC1, CEBPA, NKX2-2, MAFG, AFF4, MEF2A, CREBBP, ZNF384, ZEB2, MAFB, SUPT5H, CDK8, CHD1, FOS, MED1, PML, MYB, C11orf30, L3MBTL2, RBM22, USF1, MAFK, REST, ZBTB7A, ATF7, AFF1, BCOR, MLLT1, NFATC3, PAX7, CBFA2T2, MEF2B, FOXA2, MTA3, EBF1, NFATC1, E2F8, GTF2B, MAFF, MEF2C, ZBTB33, CDK9, HOXB13, BCL3, KDM1A, YY1, RELA, TARDBP, JUNB, ZNF830, SKIL, MAX, PLAG1, CEBPG, ZNF592, NR2F1, TBX21, BHLHE40, AR, ZBTB40, RNF2, BRD4, CLOCK, ZNF24, ZNF316
- Target gene symbol (double-evidenced CRMs): SAMSN1,RBM11,NRIP1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 230
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000185272,
ENSG00000155307,
ENSG00000180530,
- Related loop:
chr21:14225000-14250000~~chr21:14525000-14550000,
chr21:14525000-14550000~~chr21:14675000-14700000,
chr21:14525000-14550000~~chr21:14725000-14750000,
chr21:14525000-14550000~~chr21:14750000-14775000,
chr21:14525000-14550000~~chr21:15050000-15075000,
chr21:14525000-14550000~~chr21:25450000-25475000,
chr21:14526513-14528106~~chr21:14545508-14547033,
chr21:14533231-14535623~~chr21:14685023-14689153,
chr21:14533236-14535518~~chr21:14762302-14764315,