- Basic information
- CohesinDB ID: CDBP00413265
- Locus: chr21-14541246-14550672
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR404BPV, GSE103477, ENCSR917QNE, GSE93080, ENCSR000EAC, ENCSR000DZP, ENCSR000BKV, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE98367, ENCSR879KXD, GSE206145, GSE62063, ENCSR000BMY, GSE38395, GSE155324, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE50893, GSE126755, ENCSR000ECS, GSE131577
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Cell type: MDM, GM2610, GM19240, Liver, HuCC-T1, B-cell, GM2630, Fibroblast, HeLa-S3, hLCL, GM2255, K-562, SNYDER, Monocytes, GM18505, Lymphoblast, GM12878, GM12891, GM2588, GM19239, Macrophage, Ramos, GM12892, HL-60, MCF-10A, Neurons-H1, HCAEC, Neutrophil
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 12% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.689
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
41% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 27%,
"7_Enh": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, CBX5, PGR, MEIS2, FOXA1, RBFOX2, PBX2, UBTF, HDGF, LYL1, ATF3, NFIC, RUNX3, ATF4, CBFB, MECOM, SMARCE1, PAX5, MITF, HDAC3, BACH2, MAF, INTS11, THRAP3, ELF1, TRIM28, BCLAF1, JMJD1C, ETV1, NFE2L2, KLF6, SMAD5, ZNF217, OCA2, LMO2, MLL, ESR1, HNF1B, USF2, CTCF, TCF12, SND1, EP300, E4F1, JUN, MNT, LMO1, KLF1, ZNF157, DPF2, PAX8, TRIM24, IRF4, RFX5, SOX6, RAD51, E2F1, SMC1, TEAD4, KMT2B, GTF2F1, RBPJ, EED, POU2F2, TOP2A, CDK7, RUNX1T1, CTBP1, MTA2, ZNF317, STAT1, DDX5, NBN, ARID3A, TBP, ERG, ZNF597, SMARCC2, ZNF341, MYC, ETS1, SMARCA4, RFX1, ARID1B, RAD21, FOXP2, GRHL3, FOXK2, BATF3, GABPA, STAT3, IKZF1, NFE2, TERF2, NR2F6, ZNF639, NFRKB, RCOR1, NFKB2, CEBPB, VDR, NR3C1, STAT5B, KMT2A, CREB1, TBL1XR1, GABPB1, PHF8, ELF4, SPI1, EHF, IRF1, ZNF395, HDAC2, GATA2, INTS13, GATAD2B, TAF9B, FLI1, DRAP1, MXI1, SMARCA5, RELB, HEXIM1-CDK9, EP400, ZIM3, NCOA2, ATF1, CC2D1A, RUNX1, BCL6, SMC1A, HDAC1, CEBPA, MAFG, CBX1, AFF4, ZFX, SIN3A, PALB2, TRIM22, ZMIZ1, MEF2A, MYBL2, ZBTB2, IRF2, NOTCH1, ZNF384, ARNT, PBX4, BACH1, ATF2, HMBOX1, ZEB2, NFYA, FOXM1, MAFB, ETV6, CHD1, FOS, SUPT5H, CDK8, PBX3, MED1, CBFA2T3, GMEB1, NR2C1, TERF1, PML, MYB, CEBPD, ZMYM3, SMAD1, TAF7, C11orf30, NCOA1, L3MBTL2, EVI1, STAT5A, NUP98-HOXA9, SP1, BCL11A, NR4A1, REST, ZBTB7A, RBM25, CCNT2, ATF7, ASH2L, AFF1, BCOR, FOXP1, MBD2, TCF3, SMC3, MLLT1, STAG2, NFATC3, SKI, ZNF283, MEF2B, FOXA2, MTA3, CREM, CBX3, NFATC1, E2F8, EBF1, ZNF207, GTF2B, ZBED1, CHD2, MEF2C, TCF7, CDK9, HOXB13, BCL3, ZKSCAN1, KDM1A, YY1, RELA, TARDBP, JUNB, AHR, NEUROD1, CHAMP1, ZNF830, ZFP36, HIF1A, SKIL, GATA3, BATF, TAL1, MAX, SPIB, ZNF143, MTA1, GATA1, HAND2, CEBPG, ZNF592, GFI1B, NR2F2, TCF7L2, NR2F1, KDM5B, ZNF687, PKNOX1, TP53, NFKB1, ELF3, TBX21, BHLHE40, AR, TAF1, ZBTB16, ZBTB40, RXR, EGLN2, EGR1, MYNN, NCOR1, IKZF2, BRD4, RNF2, ILF3, JUND, HSF1, SCRT1, ZNF24, ADNP, ZNF316
- Target gene symbol (double-evidenced CRMs): RBM11,NRIP1,SAMSN1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 389
- Number of somatic mutations (non-coding): 33
- Related genes and loops
- Related gene:
ENSG00000185272,
ENSG00000155307,
ENSG00000180530,
- Related loop:
chr21:14225000-14250000~~chr21:14525000-14550000,
chr21:14525000-14550000~~chr21:14675000-14700000,
chr21:14525000-14550000~~chr21:14725000-14750000,
chr21:14525000-14550000~~chr21:14750000-14775000,
chr21:14525000-14550000~~chr21:15050000-15075000,
chr21:14525000-14550000~~chr21:25450000-25475000,
chr21:14526513-14528106~~chr21:14545508-14547033,
chr21:14545597-14546983~~chr21:14675233-14677002,