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Basic information

CohesinDB ID: CDBP00413319

Locus: chr21-14735214-14740505

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE101921, ENCSR806UKK, GSE51234, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE130140, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE106870, ENCSR193NSH, GSE206145, ENCSR000ECE, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE105028, ENCSR000EDW, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CUTLL1, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, T-47D, A-549, HUVEC, HCAEC, Ramos, GM19238, HeLa, TC-71, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 60% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.244

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 41% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 71%, "7_Enh": 14%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFATC3, RUNX1, SKI, FOSL1, SMC1A, CEBPA, POU5F1, CREM, GTF2B, STAT1, FOXA1, MLLT3, ZBTB33, MEF2C, SRF, TRIM22, KDM1A, ERG, RELA, ZBTB2, TARDBP, ZNF384, YY1, JUNB, CHAMP1, RUNX3, RAD21, PRDM1, SKIL, SMARCE1, ETV6, GATA1, CDK8, IKZF1, FOS, ELF1, TRIM28, MYB, KMT2A, ESR1, MLL, ZNF41, CTCF, SPI1, NIPBL, TBX21, NR4A1, AR, BCL11A, DPF2, ATF1, GATA2, REST, ATF7, IKZF2, JUND, BRD4, RELB, TEAD4, ZNF24, RBPJ, EED

Target gene symbol (double-evidenced CRMs): SAMSN1,RBM11

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 28

Related genes and loops

Related gene: ENSG00000185272, ENSG00000155307,

eachgene

Deatailed information for cohesin site CDBP00413319