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Basic information

CohesinDB ID: CDBP00413324

Locus: chr21-14752293-14755665

Data sourse: GSE143937, ENCSR000BKV, ENCSR000FAD, ENCSR000EGW, ENCSR879KXD, GSE73207

Cell type: K-562, TF-1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SMC3,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS,TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 47% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 71%, "7_Enh": 8%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, CD74, SOX2, MEIS2, HMGN3, NME2, FOXA1, SUZ12, RBFOX2, PBX2, UBTF, HNRNPK, TFAP4, HDGF, LYL1, ZNF274, ATF3, NFIC, BMI1, HNRNPUL1, RUNX3, PRDM1, ZNF207, ATF4, CBFB, SMARCE1, PAX5, ZSCAN4, MITF, HDAC3, BACH2, MAF, JMJD1C, THRAP3, ELF1, TRIM28, BCLAF1, RBM39, MCM7, NFE2L2, E2F5, SMAD5, ESR1, OCA2, LMO2, ZNF217, MLL, USF2, ZFP91, CTCF, TCF12, JUN, EP300, E4F1, KLF1, MNT, PYGO2, DPF2, E2F6, SIX5, TRIM24, IRF4, SOX6, CREB3, RAD51, ZNF410, DDX20, PBX3, E2F1, ZNF280A, TEAD4, KMT2B, ZNF175, GTF2F1, EHMT2, RBPJ, EED, DACH1, POU2F2, POU5F1, ZNF263, TOP2A, ID3, BRD3, CTBP1, MTA2, DUX4, STAT1, HINFP, NONO, DDX5, NBN, ARID3A, PHB2, TBP, ERG, HOXC5, PBX1, MIER1, SMARCC2, MYC, EZH1, SMARCA4, RFX1, ARID1B, ONECUT1, RAD21, GRHL3, FOXK2, GABPA, STAT3, XRCC5, NKX3-1, IKZF1, RCOR1, NFE2, ZNF639, NFRKB, VDR, NR2F6, LEF1, CEBPB, ESRRA, NR3C1, HNRNPL, STAT5B, KMT2A, CREB1, ZBTB11, TBL1XR1, GRHL2, GABPB1, ELF4, SPI1, HES1, IRF1, HDAC2, GATA2, ETV1, ZNF644, GATAD2B, ZSCAN29, TAF9B, FLI1, MXI1, NR2C2, SMARCA5, RELB, EP400, NCOA2, ATF1, CC2D1A, RUNX1, ZNF585A, SMC1A, MAFG, HDAC1, NKX2-2, LDB1, CRY1, SIRT6, ZFX, CEBPA, IKZF2, TRIM22, ZMIZ1, ZNF18, PRDM10, NSD2, SATB1, MEF2A, ZBTB2, ZNF384, IRF2, NOTCH1, CREBBP, BRD9, BCL3, ZNF184, ARNT, DAXX, TFDP1, ELK1, BACH1, ATF2, SOX11, ZEB2, HMBOX1, NFYA, CBFA2T3, FOXM1, ETV6, SUPT5H, CDK8, CHD1, NR2C1, FOS, MED1, FOXJ2, GMEB1, PML, CEBPD, MYB, SCRT2, DIDO1, SMAD1, ZMYM3, TAF7, TERF1, NCOA1, L3MBTL2, C11orf30, EVI1, SETDB1, STAT5A, KLF16, NUP98-HOXA9, MAFK, BCL11A, SP1, NIPBL, NR4A1, REST, ZBTB7A, CCNT2, RBM25, ATF7, ASH2L, AFF1, MBD2, BCOR, FOXP1, TCF3, SMC3, STAT2, ILK, MLLT1, STAG1, NCOR2, NFATC3, CBFA2T2, MEF2B, FOXA2, MTA3, RBBP5, CBX3, CREM, CHD2, E2F8, ZSCAN16, GTF2B, MAFF, ZBED1, MEIS1, FOXF1, ZBTB33, MEF2C, CDK9, ZKSCAN1, ZNF318, KDM1A, ZNF19, RELA, ZNF589, YY1, CREB3L1, TARDBP, NEUROD1, AHR, JUNB, CHAMP1, ZNF282, MAFB, ZFP36, SKIL, HIF1A, TCF4, OTX2, GATA3, BATF, MGA, TAL1, MAX, SPIB, GATA1, MTA1, ZNF143, FOXO3, PLAG1, BCL6, CEBPG, ZNF592, KLF4, GFI1B, NR2F2, ZKSCAN8, ZNF83, ZNF512, TCF7L2, NR2F1, KDM5B, TERF2, EBF1, PKNOX1, TP53, MED, ZNF334, ELF3, BRD2, TBX21, BHLHE40, AR, PAX3-FOXO1, TAF1, ZBTB16, ZBTB40, RXR, EGR1, MYNN, RNF2, NCOR1, BRD4, SCRT1, JUND, ILF3, CUX1, MAZ, HSF1, NOTCH3, IRF9, MEF2D, ZNF24, ADNP, ZNF316

Target gene symbol (double-evidenced CRMs): SAMSN1,HSPA13,RBM11

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 20

Related genes and loops

Related gene: ENSG00000185272, ENSG00000155304, ENSG00000155307,

eachgene

Deatailed information for cohesin site CDBP00413324