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Basic information

CohesinDB ID: CDBP00413344

Locus: chr21-14861730-14867468

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, Ramos, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, hLCL, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, HeLa, BGO3, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, Kelly, K-562, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 84% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.133

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 47% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 34%, "7_Enh": 34%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, HLF, RXRB, KDM3A, HDGF, PAX5, TEAD1, OCA2, HDAC8, E4F1, SOX5, KMT2B, GATAD2A, POU5F1, ZNF263, BRD3, CTBP1, STAT1, SAP130, ERG, SMARCA4, TOP1, FOXK2, RCOR1, NR2F6, DACH1, CEBPB, CREB1, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, RELB, EP400, RUNX1, CEBPA, NKX2-2, HDAC1, ZNF654, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, TFDP1, ATF2, FOXM1, SMARCB1, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, IKZF5, NFATC3, MEF2B, CBX3, CREM, NFATC1, PAF1, ZSCAN16, WT1, MEF2C, JUNB, NEUROD1, ZFP36, TCF4, BATF, SPIB, KLF4, ZFP69B, BCL11B, ELF3, ARID4B, EGLN2, ZBTB26, HSF1, ILF3, NR1H3, ZNF316, FOSL1, XBP1, PBX2, HNRNPK, ATF3, THRB, ZFP64, RUNX3, TP63, MITF, MYOG, JMJD1C, MAF, ELF1, RBM39, SNAI2, CTCF, JUN, MNT, DPF2, IRF4, PDX1, TFAP2C, RBPJ, MLX, MTA2, ZBTB48, SRF, DDX5, NBN, ONECUT1, HOMEZ, RXRA, NKX3-1, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, CCAR2, TBL1XR1, GRHL2, SSRP1, SMARCA5, NFIL3, CC2D1A, THAP11, SOX13, POU4F2, ZNF770, ARNT, BACH1, ZNF48, ETV6, PBX3, HMGXB4, TEAD3, U2AF1, USF1, SP1, TFAP2A, BCL11A, ATF7, ASH2L, CTBP2, SMC3, STAG1, MLLT1, STAG2, MTA3, MAFF, ZNF580, ZKSCAN1, KDM1A, ISL1, GATA3, TAL1, NRIP1, ZNF143, TP53, NFKB1, PHOX2B, PHF5A, BRD2, KAT8, TBX21, EGR1, RNF2, IKZF2, BRD4, JUND, CUX1, PGR, CBX5, SOX2, TFAP4, SIN3B, BMI1, CHD7, ATF4, MXD4, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, TP73, KLF1, SOX9, E2F6, TRIM24, GTF2F1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, HIC1, TBP, HNF4G, HOXC5, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, DNMT3B, EZH2, ZNF652, SPI1, HDAC2, GATAD2B, NCOA2, ETV5, BCL6, SIN3A, MEF2A, MYBL2, CREBBP, ZNF384, RARA, NFYC, HMGB2, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, NCOA1, RBM22, MAFK, HNF4A, REST, BCOR, FOXP1, NCOR2, PPARG, TBL1X, GTF2B, TCF7, ZNF823, RELA, TARDBP, CHAMP1, SKIL, MGA, MAX, ZNF592, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, AR, PAX3-FOXO1, DMAP1, AHR, FOSL2, HMG20A, MEIS2, RBFOX2, NFIC, CTCFL, PRDM1, CDX2, ZNF629, BCLAF1, TRIM28, RCOR2, HNF1B, MLL, USF2, ZFP91, TCF12, EP300, BAF155, GATA6, SOX6, RAD51, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, MYCN, ID3, MLLT3, GATAD1, ARID3A, RAD21, GRHL3, ZNF614, XRCC5, NFE2, ARNTL, ZNF750, JMJD6, TRPS1, TFE3, HBP1, IRF1, ZGPAT, MRTFB, ATF1, SMC1A, MAFG, CBX1, SIRT6, FIP1L1, ZFX, SMAD3, PRPF4, NOTCH1, RUNX2, ZSCAN30, GATA4, CDK6, PBX4, FOS, CHD1, TGIF2, MED1, CEBPD, MYB, ZNF3, L3MBTL2, NIPBL, ZBTB7A, POU2F3, PHIP, SKI, PAX7, FOXA2, E2F8, MIER2, ZBTB33, CDK9, HOXB13, YY1, HIF1A, GATA1, TLE3, CEBPG, NCOA3, NR2F2, ZNF687, NFKBIZ, BHLHE40, ZNF846, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): HSPA13,SAMSN1,NRIP1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000155304, ENSG00000155307, ENSG00000180530,

eachgene

Deatailed information for cohesin site CDBP00413344