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Basic information

CohesinDB ID: CDBP00413346

Locus: chr21-14869900-14872963

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR000DZP, ENCSR000EAC, GSE72082, GSE98367, ENCSR000BSB, ENCSR000EGW, GSE76893, GSE105028, ENCSR054FKH, GSE50893, GSE120943, GSE62063, GSE68388, ENCSR703TNG, GSE25021, GSE116344

Cell type: MCF-7, H1-hESC, Macrophage, HCT-116, Monocytes, Hep-G2, RH4, GM12878, Ramos, GM12891, K-562, HuCC-T1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 7% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.856

Subunit: NIPBL,SA1,Rad21,SMC1,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 47% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 46%, "5_TxWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, HLF, RXRB, KDM3A, HDGF, PAX5, TEAD1, OCA2, HDAC8, E4F1, SOX5, KMT2B, GATAD2A, POU5F1, ZNF263, BRD3, CTBP1, STAT1, SAP130, ERG, SMARCA4, TOP1, FOXK2, RCOR1, NR2F6, DACH1, CEBPB, CREB1, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, RELB, EP400, RUNX1, CEBPA, NKX2-2, HDAC1, ZNF654, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, TFDP1, ATF2, FOXM1, SMARCB1, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, IKZF5, NFATC3, MEF2B, CBX3, CREM, NFATC1, PAF1, ZSCAN16, WT1, MEF2C, JUNB, NEUROD1, ZFP36, TCF4, BATF, SPIB, KLF4, ZFP69B, BCL11B, ELF3, ARID4B, EGLN2, ZBTB26, HSF1, ILF3, NR1H3, ZNF316, FOSL1, XBP1, PBX2, HNRNPK, ATF3, THRB, ZFP64, RUNX3, TP63, MITF, MYOG, JMJD1C, MAF, ELF1, RBM39, SNAI2, CTCF, JUN, MNT, DPF2, IRF4, PDX1, TFAP2C, RBPJ, MLX, MTA2, ZBTB48, SRF, DDX5, NBN, ONECUT1, HOMEZ, RXRA, NKX3-1, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, CCAR2, TBL1XR1, GRHL2, SSRP1, SMARCA5, NFIL3, CC2D1A, THAP11, SOX13, POU4F2, ZNF770, ARNT, BACH1, ZNF48, ETV6, PBX3, HMGXB4, TEAD3, U2AF1, USF1, SP1, TFAP2A, BCL11A, ATF7, ASH2L, CTBP2, SMC3, STAG1, MLLT1, STAG2, MTA3, MAFF, ZNF580, ZKSCAN1, KDM1A, ISL1, GATA3, TAL1, NRIP1, ZNF143, TP53, NFKB1, PHOX2B, PHF5A, BRD2, KAT8, TBX21, EGR1, RNF2, IKZF2, BRD4, JUND, CUX1, PGR, CBX5, SOX2, TFAP4, SIN3B, BMI1, CHD7, ATF4, MXD4, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, TP73, KLF1, SOX9, E2F6, TRIM24, GTF2F1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, HIC1, TBP, HNF4G, HOXC5, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, DNMT3B, EZH2, ZNF652, SPI1, HDAC2, GATAD2B, NCOA2, ETV5, BCL6, SIN3A, MEF2A, MYBL2, CREBBP, ZNF384, RARA, NFYC, HMGB2, SMAD4, CBFA2T3, CDK8, ZEB1, ZMYM3, NCOA1, RBM22, MAFK, HNF4A, REST, BCOR, FOXP1, NCOR2, PPARG, TBL1X, GTF2B, TCF7, ZNF823, RELA, TARDBP, CHAMP1, SKIL, MGA, MAX, ZNF592, NR2F1, TCF7L2, KDM5B, PKNOX1, MYOD1, AR, PAX3-FOXO1, DMAP1, AHR, FOSL2, HMG20A, MEIS2, RBFOX2, NFIC, CTCFL, PRDM1, CDX2, ZNF629, BCLAF1, TRIM28, RCOR2, HNF1B, MLL, USF2, ZFP91, TCF12, EP300, BAF155, GATA6, SOX6, RAD51, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, MYCN, ID3, MLLT3, GATAD1, ARID3A, RAD21, GRHL3, ZNF614, XRCC5, NFE2, ARNTL, ZNF750, JMJD6, TRPS1, TFE3, HBP1, IRF1, ZGPAT, MRTFB, ATF1, SMC1A, MAFG, CBX1, SIRT6, FIP1L1, ZFX, SMAD3, PRPF4, NOTCH1, RUNX2, ZSCAN30, GATA4, CDK6, PBX4, FOS, CHD1, TGIF2, MED1, CEBPD, MYB, ZNF3, L3MBTL2, NIPBL, ZBTB7A, POU2F3, PHIP, SKI, PAX7, FOXA2, E2F8, MIER2, ZBTB33, CDK9, HOXB13, YY1, HIF1A, GATA1, TLE3, CEBPG, NCOA3, NR2F2, ZNF687, NFKBIZ, BHLHE40, ZNF846, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): SAMSN1,HSPA13,NRIP1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000155304, ENSG00000155307, ENSG00000180530,

eachgene

Deatailed information for cohesin site CDBP00413346