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Basic information

CohesinDB ID: CDBP00413347

Locus: chr21-14874201-14874958

Data sourse: GSE206145-GSE177045, GSE72082, ENCSR000BLS

Cell type: MCF-7, Hep-G2

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: Mau2,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 47% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 61%, "5_TxWk": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, MEN1, PAX5, TEAD1, LMO2, OCA2, SOX5, RFX3, GATAD2A, POU5F1, BRD3, HHEX, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, PAX6, ZNF597, SMARCA4, RCOR1, NR2F6, CEBPB, CREB1, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, FLI1, DRAP1, NR2C2, RELB, RUNX1, HDAC1, CEBPA, NKX2-2, CRY1, TBX3, SP5, TRIM22, SMARCC1, ZXDC, ZBTB2, ATF2, FOXM1, SMARCB1, PML, TERF1, PIAS1, SMAD1, NR1H2, MBD1, STAT5A, IKZF5, ZNF605, MBD2, ETV4, NFATC3, MEF2B, CREM, PAF1, NFATC1, MEF2C, JUNB, NEUROD1, TCF4, BATF, SPIB, KLF4, ELF3, ARID4B, RXR, ZBTB26, NCOR1, HSF1, ZNF316, FOSL1, HNF1A, TSC22D4, ATF3, THRB, ZFP64, HNRNPUL1, RUNX3, WDHD1, CBFB, TP63, BACH2, ELF1, KLF10, JUN, CTCF, TAF3, L3MBTL4, MNT, DPF2, IRF4, PDX1, RBPJ, TFAP2C, MLX, MTA2, SRF, DDX5, NBN, ONECUT1, HOMEZ, FOXP2, LHX2, RXRA, NKX3-1, MIER3, VDR, NR3C1, ESRRA, KMT2A, TBL1XR1, GRHL2, SSRP1, ZSCAN29, SMARCA5, NFIL3, THAP11, CTNNB1, EZH2phosphoT487, AFF4, SOX13, POU4F2, ARNT, DAXX, HMBOX1, ZEB2, ETV6, PBX3, HMGXB4, TEAD3, USF1, BCL11A, SP1, ATF7, ASH2L, CTBP2, SMC3, MLLT1, STAG1, STAG2, MTA3, EBF1, MAFF, ESR2, ZNF580, BCL3, KDM1A, ZNF19, ZIC2, GATA3, TAL1, NRIP1, ZNF143, TP53, ZNF334, NFKB1, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, IKZF2, BRD4, JUND, CUX1, SMAD4.1D12, PGR, CBX5, SOX2, TFAP4, BMI1, CHD7, MXD4, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, TP73, SOX9, POU2F2, TBP, HNF4G, HOXC5, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, EZH2, ZNF652, SPI1, HDAC2, GATAD2B, ZNF490, NCOA2, ETV5, BCL6, SIN3A, MEF2A, MYBL2, CREBBP, RARA, ZNF384, ZNF133, NFYC, SMAD4, CDK8, ZEB1, SREBF2, MAFK, HNF4A, NR4A1, REST, ARID1A, BCOR, FOXP1, NCOR2, PPARG, ZNF692, GTF2B, TCF7, FOXO3, RELA, TARDBP, SKIL, MAX, ZNF592, TCF7L2, NR2F1, PKNOX1, MYOD1, AR, YAP1, DMAP1, AHR, MBD3, FOSL2, HMG20A, LCORL, E2F7, RBFOX2, NFIC, PRDM1, CDX2, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, HNF1B, MLL, USF2, MBD4, TCF12, BAF155, EP300, GATA6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, GATAD1, ARID3A, ZNF300, RAD21, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF750, TRPS1, TFE3, EHF, HBP1, IRF1, ZGPAT, MRTFB, CBX1, SMC1A, MAFG, ZFX, SMAD3, PRPF4, RUNX2, GATA4, PBX4, NR2C1, FOS, MED1, CEBPD, ZNF3, NIPBL, ZBTB7A, PHIP, TCF3, PAX7, SKI, FOXA2, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, OTX2, BHLHE22, GATA1, TLE3, CEBPG, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, NOTCH3, ZNF24

Target gene symbol (double-evidenced CRMs): SAMSN1,HSPA13,NRIP1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000155304, ENSG00000155307, ENSG00000180530,

eachgene

Deatailed information for cohesin site CDBP00413347