- Basic information
- CohesinDB ID: CDBP00413380
- Locus: chr21-14968863-14969588
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Data sourse: GSE206145, GSE206145-NatGen2015
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Cell type: RPE, Fibroblast
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.978
- Subunit: Mau2,NIPBL,Rad21,SA2
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
47% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 70%,
"4_Tx": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, PGR, ZNF660, SOX2, NME2, XBP1, FOXA1, HLF, SRSF4, CHD7, PRDM1, TEAD1, TRIM28, BCLAF1, SNAI2, ESR1, OCA2, JUN, CTCF, GATA6, SOX5, GATAD2A, TFAP2C, EED, CHD8, POU5F1, TOP2A, ZNF317, ZNF205, MLLT3, HOXC5, ERG, MYC, RAD21, GRHL3, RXRA, NKX2-1, PROX1, STAT3, IKZF1, NR3C1, CEBPB, EPAS1, EZH2, ZNF652, SPI1, IRF1, GATA2, FLI1, SMC1A, CEBPA, SOX13, ZNF534, SMAD3, RUNX2, GATA4, GR, ARNT, PBX4, DAXX, FOS, SUPT5H, MED1, PML, CEBPD, MYB, ZMYM3, SUPT16H, HIF2A, RBM22, BCL11A, TFAP2A, HNF4A, ZNF605, SRSF9, PHIP, SMC3, NCOR2, ZNF283, PPARG, FOXA2, PAF1, ZSCAN16, ZNF823, HOXB13, BCL3, RELA, JUNB, HIF1A, GATA3, MAX, GATA1, AGO2, ZNF143, KLF4, CEBPG, NCOA3, NR2F2, TCF7L2, AR, EGLN2, NOTCH3, BRD4, JUND, SCRT1, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): SAMSN1,HSPA13,RBM11,NRIP1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 6
- Number of somatic mutations (non-coding): 2
- Related genes and loops
- Related gene:
ENSG00000185272,
ENSG00000155304,
ENSG00000155307,
ENSG00000180530,
- Related loop:
chr21:14225000-14250000~~chr21:14950000-14975000,
chr21:14275000-14300000~~chr21:14950000-14975000,
chr21:14375000-14400000~~chr21:14950000-14975000,
chr21:14475000-14500000~~chr21:14950000-14975000,
chr21:14650000-14675000~~chr21:14950000-14975000,
chr21:14775000-14800000~~chr21:14950000-14975000,
chr21:14850000-14875000~~chr21:14950000-14975000,
chr21:14950000-14975000~~chr21:15125000-15150000,
chr21:14950000-14975000~~chr21:15150000-15175000,
chr21:14950000-14975000~~chr21:15250000-15275000,
chr21:14950000-14975000~~chr21:15275000-15300000,
chr21:14950000-14975000~~chr21:15425000-15450000,
chr21:14950000-14975000~~chr21:15450000-15475000,
chr21:14950000-14975000~~chr21:15475000-15500000,
chr21:14950000-14975000~~chr21:15525000-15550000,
chr21:14950000-14975000~~chr21:15575000-15600000,
chr21:14950000-14975000~~chr21:16125000-16150000,