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Basic information

CohesinDB ID: CDBP00413381

Locus: chr21-14977644-14978098

Data sourse: GSE116344, GSE62063, GSE83726

Cell type: RH4, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: NIPBL,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 47% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 64%, "15_Quies": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, HMG20A, ZNF660, NME2, FOXA1, RXRB, NFIC, ZBTB44, ATF4, MYOG, TRIM28, SNAI2, LMO2, ESR1, MLL, EP300, TRIM24, FOXA3, GATAD2A, NANOG, TOP2A, MLLT3, ZNF300, ERG, ASCL1, USP7, MYC, SMARCA4, HOMEZ, RAD21, LHX2, RXRA, NKX2-1, GABPA, NR2F6, NR3C1, ESRRA, CEBPB, KMT2A, SPI1, HDAC2, GATA2, ZNF644, NFIL3, MRTFB, NCOA2, RUNX1, THAP11, BCL6, CEBPA, NKX2-2, SOX13, RARA, RUNX2, CDK6, ZNF184, NFIB, DAXX, ZNF48, SMAD4, SUPT5H, CDK8, PIAS1, RBM22, NUP98-HOXA9, BCL11A, SP1, HNF4A, HOXA9, MLLT1, ZNF394, FOXA2, SS18, PAF1, GTF2B, MEF2C, HOXB13, KDM1A, YY1, RELA, GATA3, TAL1, MAX, NRIP1, GATA1, AGO2, HAND2, CEBPG, NR2F2, NR2F1, MYOD1, BRD2, AR, BRD4, JUND

Target gene symbol (double-evidenced CRMs): NRIP1,USP25

Function elements

Human SNPs: .

Number of somatic mutations (coding): 45

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000180530, ENSG00000155313,

eachgene

Deatailed information for cohesin site CDBP00413381