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Basic information

CohesinDB ID: CDBP00413388

Locus: chr21-14995418-14997309

Data sourse: ENCSR000BLD, GSE138405, GSE206145, GSE206145-NatGen2015, GSE138105, GSE116344, GSE165895

Cell type: RPE, H1-hESC, Fibroblast, RH4, Hela-Kyoto, SLK, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 4% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 47% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 55%, "7_Enh": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, BCL6, BRD1, CEBPA, NKX2-2, LDB1, MYCN, PAF1, MEIS2, NME2, BRD3, GTF2B, SOX13, FOXA1, SRF, SAP130, HOXB13, ERG, YY1, RELA, ZBTB2, ETS1, MYC, RUNX2, HOMEZ, RAD21, PBX4, GATAD2A, NKX2-1, GABPA, TAL1, SMARCE1, XRCC5, NKX3-1, GATA1, CDK8, AGO2, ZNF614, TLE3, NR3C1, CEBPG, TEAD3, TEAD1, TRIM28, KMT2A, ETV1, PIAS1, KLF6, JUN, RBM22, ZHX2, EP300, SPI1, BCL11A, CTCF, AR, IRF1, BRD2, PAX8, FOXA2, GATA2, YAP1, ZNF644, FLI1, ASH2L, ZBTB26, BRD4, FOXP1, MRTFB, TEAD4, FOXA3, ZNF24, MLLT1, AHR

Target gene symbol (double-evidenced CRMs): USP25,NRIP1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 27

Number of somatic mutations (non-coding): 9

Related genes and loops

Related gene: ENSG00000180530, ENSG00000155313,

eachgene

Deatailed information for cohesin site CDBP00413388