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Basic information

CohesinDB ID: CDBP00413405

Locus: chr21-15050583-15051369

Data sourse: ENCSR000BLD, ENCSR167MTG, ENCSR000EEG, GSE72082, GSE25021, ENCSR000BLS, GSE105028, GSE206145, ENCSR000ECE, ENCSR000BMY, GSE106870, GSE50893, GSE145327, GSE97394

Cell type: MCF-7, H1-hESC, RPE, HEK293T, Hep-G2, CVB-hiPSC, GM12878, HUES64, CVI-hiPSC, GM18486, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 5% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.878

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 52% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 41%, "5_TxWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, ZNF675, FOXA1, HLF, RXRB, KDM3A, HDGF, MEN1, THAP1, ZBTB44, IKZF3, ZNF429, MORC2, PAX5, SFPQ, TEAD1, LMO2, OCA2, MED26, HDAC8, ZNF561, SOX5, PAX8, E2F4, DEK, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, POU5F1, BRD3, TOP2A, ZNF263, CTBP1, DUX4, STAT1, SAP130, PAX6, ERG, ZBTB8A, EZH1, SMARCA4, RFX1, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, HCFC1, RELB, EP400, RUVBL2, RUNX1, HDAC1, NKX2-2, CEBPA, ZNF707, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, TFDP1, ATF2, FOXM1, SP2, SMARCB1, GMEB1, TERF1, PML, PIAS1, SMAD1, NR1H2, C11orf30, MBD1, STAT5A, GSPT2, ARID2, IKZF5, AFF1, MBD2, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, CREM, CHD2, PAF1, NFATC1, ZSCAN16, WT1, MEF2C, JUNB, NEUROD1, ZFP36, BATF, MAF1, SPIB, PLAG1, KLF4, BCL11B, ZKSCAN8, ZBTB6, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, FOSL1, ZNF660, HNF1A, ZNF101, KDM4B, SRSF4, PBX2, HNRNPK, ATF3, ZFP64, HNRNPUL1, RUNX3, CBFB, ZNF273, TP63, MITF, BACH2, ZNF467, JMJD1C, MAF, INTS11, ELF1, ZNF573, RBM39, SMAD5, FUS, CTCF, JUN, TAF3, MNT, ZBTB20, DPF2, RYBP, SIX5, IRF4, PDX1, TFAP2C, RBPJ, MLX, MTA2, ZBTB17, ZNF317, ZBTB48, NONO, SRF, DDX5, NBN, PBX1, ONECUT1, KDM4A, HOMEZ, ZKSCAN2, LHX2, FOXP2, RXRA, BATF3, NKX3-1, PRDM14, LEF1, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, ZBTB11, KLF8, GRHL2, KDM5A, ZBTB14, SSRP1, ZSCAN29, SMARCA5, NFIL3, THAP11, EZH2phosphoT487, SOX13, AFF4, POU4F2, ZNF770, ZMIZ1, SP3, DAXX, ARNT, BACH1, NFIB, ZNF48, HMBOX1, ZEB2, ETV6, MAFB, ZNF10, NCAPH2, HMGXB4, PBX3, TEAD3, U2AF1, KLF9, TBX5, USF1, BCL11A, SP1, ZNF479, ATF7, ASH2L, CTBP2, PCGF2, GLIS2, PRDM6, SMC3, STAT2, STAG1, MLLT1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, ESR2, ZNF580, ZKSCAN1, KDM1A, ZNF19, ZNF441, BRG1, ISL1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, TP53, ZNF334, NFKB1, ZSCAN22, PHOX2B, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, SPIN1, CUX1, ZSCAN23, TBX2, ZNF468, PGR, FANCL, SOX2, PATZ1, RING1B, UBTF, TFAP4, SIN3B, BMI1, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, SAP30, KLF1, SOX4, E2F6, TRIM24, RFX5, U2AF2, GTF2F1, GLIS1, POU2F2, ZNF778, KDM4C, ZSCAN5A, HIC1, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, DNMT3B, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF786, ZNF202, PCBP1, HDAC2, INTS13, ZNF182, GATAD2B, ZNF777, NCOA2, ETV5, BCL6, SIN3A, ZFP37, ERG3, MEF2A, CREBBP, RARA, ZNF35, ZNF384, TAF15, NFYC, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, SPDEF, ZNF250, ZMYM3, SUPT16H, NCOA1, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, ZNF34, CXXC4, PPARG, TBL1X, ZNF692, GTF2B, ZNF574, TCF7, YY2, FOXO3, RELA, TARDBP, SKIL, ZNF611, MAX, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, NEUROG2, PKNOX1, MYOD1, T, AR, PAX3-FOXO1, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, SFMBT1, ZNF90, NFIC, ZNF362, CTCFL, PRDM1, MECOM, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, HNF1B, USF2, MBD4, TCF12, BAF155, EP300, GATA6, PRDM4, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, ZNF425, CHD8, BRD1, MYCN, RUNX1T1, ZNF205, MLLT3, GATAD1, ARID3A, MIER1, ZNF341, ZNF84, EOMES, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF501, JMJD6, FEZF1, TFE3, HBP1, IRF1, SREBF1, ZGPAT, ZNF766, MRTFB, MYF5, ATF1, PTBP1, MAFG, SMC1A, CBX1, SIRT6, ZNF335, FIP1L1, ZFX, ZNF534, SMAD3, TWIST1, IRF2, NOTCH1, RUNX2, CDK6, GATA4, OSR2, ZSCAN30, SMAD2, PBX4, NRF1, FOS, CHD1, SUPT5H, TGIF2, MED1, CEBPD, MYB, SCRT2, KDM6B, ZNF558, VEZF1, ZNF3, L3MBTL2, NUP98-HOXA9, NIPBL, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, ZNF783, SKI, NELFA, FOXA2, RBBP5, MIER2, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, ZNF610, SP140, HIF1A, OTX2, ZNF519, ZNF740, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, NFKBIZ, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, NOTCH3, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): NRIP1,USP25,HSPA13,SAMSN1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 9

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000155304, ENSG00000155307, ENSG00000180530, ENSG00000155313,

eachgene

Deatailed information for cohesin site CDBP00413405