- Basic information
- CohesinDB ID: CDBP00413436
- Locus: chr21-15172374-15174253
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Data sourse: ENCSR000BTQ, GSE206145-GSE177045, ENCSR000EEG, ENCSR230ZWH, GSE72082, GSE76893, ENCSR000BLS, ENCSR054FKH, ENCSR703TNG, GSE25021, GSE115602
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Cell type: MCF-7, Liver, Hep-G2
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 7% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: NIPBL,SA1,Rad21,SMC1,Mau2
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
52% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 91%,
"7_Enh": 4%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: MBD3, NFIA, PGR, HMG20A, FOXA1, HLF, RXRB, MEN1, NFIC, TEAD1, ZNF217, ESR1, RCOR2, JUN, TCF12, BAF155, EP300, SOX5, GATA6, MED12, NR5A2, TEAD4, FOXA3, GATAD2A, PDX1, TFAP2C, CTBP1, DUX4, UTX, SRF, ARID3A, ERG, ASCL1, EOMES, HOMEZ, RAD21, RXRA, GABPA, ZNF614, NKX3-1, MIER3, RCOR1, NR2F6, NR3C1, ESRRA, CEBPB, CREB1, GRHL2, ZNF652, TRPS1, MIXL1, ZSCAN2, HDAC2, GATA2, ZNF644, MXD3, SIX2, DRAP1, ZGPAT, ZNF766, NFIL3, NCOA2, THAP11, BCL6, SMC1A, CEBPA, NKX2-2, SOX13, SIN3A, SMAD3, MYBL2, ZXDC, RARA, CREBBP, RUNX2, GATA4, NFIB, ARNT, SMAD4, FOXM1, MAFB, MED1, TEAD3, PIAS1, NCOA1, MAFK, NIPBL, TFAP2A, ATF7, CTBP2, MBD2, FOXP1, STAG1, PPARG, FOXA2, CREM, MIER2, MAFF, TCF7, HOXB13, KDM1A, RELA, GATA3, MAX, NRIP1, TLE3, CEBPG, NCOA3, NR2F2, NR2F1, TCF7L2, ELF3, KAT8, ARID4B, AR, NFKBIZ, ZNF579, JUND, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): NRIP1,RBM11,SAMSN1,HSPA13
- Function elements
- Human SNPs: Lung_function_(FVC)
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 12
- Related genes and loops
- Related gene:
ENSG00000185272,
ENSG00000155304,
ENSG00000155307,
ENSG00000180530,
- Related loop:
chr21:14100000-14125000~~chr21:15150000-15175000,
chr21:14225000-14250000~~chr21:15150000-15175000,
chr21:14275000-14300000~~chr21:15150000-15175000,
chr21:14375000-14400000~~chr21:15150000-15175000,
chr21:14450000-14475000~~chr21:15150000-15175000,
chr21:14500000-14525000~~chr21:15150000-15175000,
chr21:14600000-14625000~~chr21:15150000-15175000,
chr21:14775000-14800000~~chr21:15150000-15175000,
chr21:14850000-14875000~~chr21:15150000-15175000,
chr21:14875000-14900000~~chr21:15150000-15175000,
chr21:14950000-14975000~~chr21:15150000-15175000,
chr21:14975000-15000000~~chr21:15150000-15175000,
chr21:14975000-15000000~~chr21:15175000-15200000,
chr21:15150000-15175000~~chr21:15250000-15275000,
chr21:15150000-15175000~~chr21:15275000-15300000,
chr21:15150000-15175000~~chr21:15425000-15450000,
chr21:15150000-15175000~~chr21:15450000-15475000,
chr21:15150000-15175000~~chr21:15475000-15500000,