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Basic information

CohesinDB ID: CDBP00413443

Locus: chr21-15198385-15201877

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, GSE105028, ENCSR000ECS, GSE103477, GSE25021, GSE108869, ENCSR000BTU, GSE138405, GSE76893, GSE101921, GSE116344, ENCSR703TNG, ENCSR000EEG, GSE98367, ENCSR000BLS, GSE206145, ENCSR000ECE, ENCSR981FDC, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR748MVX

Cell type: MCF-7, H1-hESC, HMEC, Hela-Kyoto, Macrophage, MDM, HEK293T, Hep-G2, RH4, Ishikawa, A-549, GM12891, HeLa-S3, HUES64, K-562, HuCC-T1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 14% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.811

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 52% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 63%, "7_Enh": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: SMC1A, NCOA3, BRD3, HOMEZ, RAD21, GRHL3, ESR1, JUND, JUN, HIF1A, ATF2, GATA3, CTCF, NCOR2

Target gene symbol (double-evidenced CRMs): NRIP1

Function elements

Human SNPs: Cancer_(pleiotropy)

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 21

Related genes and loops

Related gene: ENSG00000180530,

eachgene

Deatailed information for cohesin site CDBP00413443