- Basic information
- CohesinDB ID: CDBP00413447
- Locus: chr21-15218446-15220810
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE105028, GSE131606, GSE25021, ENCSR330ELC, ENCSR000BKV, GSE86191, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, ENCSR199XBQ, GSE98367, GSE206145, ENCSR767DFK, ENCSR984DZW, ENCSR495WGO, ENCSR217ELF, ENCSR853VWZ, ENCSR676MJK, GSE111913, ENCSR054FKH, ENCSR748MVX, GSE38411
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Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, Monocytes, Hep-G2, Neurons-H1, A-549, RT-112, H9-hESC, K-562, BCBL-1, Macrophage, DKO
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 8% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.833
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
52% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 61%,
"7_Enh": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, ZNF660, SOX2, HMGN3, HNF1A, FOXA1, HLF, PBX2, RXRB, ZFHX2, KDM3A, TFAP4, TSC22D4, THRB, ATF3, NFIC, ZFP64, RUNX3, CHD7, ATF4, MXD4, ZNF189, MECOM, PAX5, TP63, MITF, BACH2, CDX2, JMJD1C, MAF, TEAD1, BCLAF1, TRIM28, KLF6, ETV1, NFE2L2, ELF1, RCOR2, ESR1, SAP30, KLF10, MLL, USF2, JUN, TCF12, CTCF, BAF155, EP300, POU2F1, MNT, SOX5, GATA6, DMAP1, TRIM24, RFX5, SMC1, RFX3, TEAD4, FOXA3, ZNF175, KMT2B, GATAD2A, GTF2F1, RBPJ, MLX, TFAP2C, PDX1, SRF, NANOG, CHD8, POU2F2, BRD3, MYCN, POU5F1, ZMYND11, STAT1, MLLT3, GATAD1, DDX5, ZNF485, SAP130, ARID3A, ERG2, TBP, HNF4G, ERG, PAX6, HOXC5, HIC1, PBX1, ETS1, MYC, ONECUT1, SMARCA4, EOMES, ARID1B, RAD21, HOMEZ, GRHL3, LHX2, FOXP2, RXRA, NKX2-1, FOXK2, BATF3, GABPA, ZNF197, STAT3, ZNF614, APC, XRCC5, PRDM14, IKZF1, MIER3, RCOR1, NR2F6, TERF2, VDR, NR3C1, CEBPB, ESRRA, ZNF750, KMT2A, CREB1, CCAR2, TBL1XR1, EZH2, GRHL2, ZNF652, GABPB1, ZHX2, SPI1, MIXL1, EHF, TFE3, IRF1, HBP1, HDAC2, GATA2, ZNF644, MXD3, FLI1, DRAP1, ZGPAT, NFIL3, MRTFB, NCOA2, ETV5, RUNX1, THAP11, BCL6, SMC1A, CEBPA, NKX2-2, HDAC1, EZH2phosphoT487, SIN3A, SOX13, AFF4, ZFX, POU4F2, SMAD3, ERG3, SP5, SMARCC1, MEF2A, MYBL2, RARA, ZNF384, ZBTB2, ZNF35, NFYC, RUNX2, SMAD2, CDK6, GATA4, ZNF184, OSR2, ARNT, PBX4, DAXX, NRF1, ZNF48, ATF2, HMBOX1, PBX3, FOXM1, NR2C1, FOS, CDK8, HMGXB4, TGIF2, MED1, TEAD3, DIDO1, SPDEF, CEBPD, MYB, PIAS1, ZEB1, SMAD1, ZNF3, ZMYM3, RBM22, MAFK, BCL11A, SP1, NIPBL, HNF4A, NR4A1, IKZF5, REST, ARID1A, NKX2-5, ZNF479, ASH2L, PHIP, TCF3, FOXP1, BCOR, SMC3, ELL2, STAG2, MLLT1, ETV4, STAG1, SKI, PPARG, FOXA2, CBX3, CREM, CHD2, MIER2, GTF2B, MAFF, WT1, ZBTB33, TCF7, MEF2C, CDK9, ZNF823, HOXB13, BCL3, ZKSCAN1, KDM1A, YY1, RELA, ZNF580, FOXO3, JUNB, NEUROD1, BRCA1, ISL1, ZIC2, HIF1A, OTX2, GATA3, BATF, TAL1, MAX, MAF1, GATA1, HAND2, CEBPG, KLF4, SP7, NCOA3, NR2F2, TCF7L2, NR2F1, TP53, PKNOX1, BCL6B, NFKB1, EGR2, PHOX2B, ELF3, BRD2, KAT8, PHF5A, T, MYOD1, ARID4B, AR, NFKBIZ, RXR, ZBTB26, RNF2, BRD4, JUND, NR1H3, CUX1, SMAD4.1D12, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): NRIP1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 18
- Related genes and loops
- Related gene:
ENSG00000180530,
- Related loop:
chr21:14850000-14875000~~chr21:15200000-15225000,
chr21:14850000-14875000~~chr21:15225000-15250000,
chr21:14875000-14900000~~chr21:15200000-15225000,
chr21:14875000-14900000~~chr21:15225000-15250000,
chr21:15025000-15050000~~chr21:15200000-15225000,
chr21:15050000-15075000~~chr21:15200000-15225000,
chr21:15050000-15075000~~chr21:15225000-15250000,
chr21:15075000-15100000~~chr21:15200000-15225000,
chr21:15200000-15225000~~chr21:15425000-15450000,
chr21:15200000-15225000~~chr21:15450000-15475000,
chr21:15200000-15225000~~chr21:15475000-15500000,
chr21:15221555-15222862~~chr21:15482170-15484279,
chr21:15225000-15250000~~chr21:15325000-15350000,
chr21:15225000-15250000~~chr21:15475000-15500000,
chr21:15225000-15250000~~chr21:15575000-15600000,