- Basic information
- CohesinDB ID: CDBP00413518
- Locus: chr21-15520334-15522556
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE116868, ENCSR000BLY, GSE105028, GSE121355, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, ENCSR000DZP, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, GSE135093, GSE152721, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, ENCSR000EEG, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE50893, ENCSR000ECS
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Cell type: RH4, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, Ishikawa, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, H1-hESC, GM18505, MB157, GM12878, SK-N-SH, RT-112, HAP1, GM19099, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, Hep-G2, HCAEC, GM19238, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 20% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.656
- Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
56% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 53%,
"9_Het": 14%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, TRP47, SMC1A, CHD8, CEBPA, POU5F1, NKX2-2, TOP2A, MYCN, ZFX, ZSCAN5D, RUNX1T1, MAFF, SMAD3, ZBTB48, FOXA1, WT1, SRF, TET2, ZSCAN5A, HOXB13, KDM1A, ERG, RELA, ZBTB2, MYC, CTCFL, RAD21, HOMEZ, SP140, GABPA, TAL1, PAX5, ZNF614, NKX3-1, TP63, HMGXB4, NCOA3, TEAD3, TRIM28, ZNF680, NEUROG2, ESR1, OCA2, GABPB1, CTCF, ELF3, MAFK, SPI1, JUN, HNF4A, AR, ZBTB40, ZNF479, NOTCH3, BRD4, SMC1, AATF, SMC3, GATAD2A, STAG1, TFAP2C
- Target gene symbol (double-evidenced CRMs): USP25
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 12
- Related genes and loops
- Related gene:
ENSG00000155313,
- Related loop:
chr21:14825000-14850000~~chr21:15500000-15525000,
chr21:14850000-14875000~~chr21:15525000-15550000,
chr21:14950000-14975000~~chr21:15525000-15550000,
chr21:15079778-15081441~~chr21:15520342-15521628,
chr21:15241528-15243057~~chr21:15520218-15521612,
chr21:15500000-15525000~~chr21:15825000-15850000,
chr21:15520136-15522073~~chr21:15552141-15554135,
chr21:15520229-15521680~~chr21:15825383-15827192,
chr21:15520337-15521600~~chr21:15825285-15827222,
chr21:15520438-15521729~~chr21:15825379-15827213,