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Basic information

CohesinDB ID: CDBP00413529

Locus: chr21-15585495-15588247

Data sourse: ShirahigeLab-GSE177045, GSE76893, GSE67783

Cell type: MCF-7, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: NIPBL,SA1,Rad21,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 56% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 89%, "14_ReprPCWk": 6%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, PGR, NANOG, FOXA2, TOP2A, CTBP1, POU4F2, GTF2B, DUX4, ESR2, FOXA1, FOXF1, HOXB13, HNF4G, ERG, RELA, CREBBP, ZXDC, ONECUT1, PRDM1, GRHL3, HIF1A, SOX11, GATA3, GABPA, FOXM1, NKX3-1, NRIP1, RCOR1, MED1, CDX2, TLE3, NR3C1, ESRRA, NCOA3, TEAD1, NR2F2, ETV1, PIAS1, CREB1, NR2F1, ZNF217, ESR1, TP53, NCOA1, GRHL2, TRPS1, PHOX2B, JUN, BAF155, TFAP2A, NIPBL, EP300, AR, NR4A1, HNF4A, DPF2, ZBTB40, HDAC2, GATA2, ARID1A, MED12, ASH2L, RAD51, BRD4, CTBP2, FOXP1, CUX1, NCOA2, TFAP2C

Target gene symbol (double-evidenced CRMs): HSPA13,USP25,NRIP1

Function elements

Human SNPs: Velopharyngeal_dysfunction

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000155304, ENSG00000180530, ENSG00000155313,

eachgene

Deatailed information for cohesin site CDBP00413529