- Basic information
- CohesinDB ID: CDBP00413562
- Locus: chr21-15705710-15707849
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Data sourse: GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000BSB, ENCSR501LQA, ENCSR000BLY, GSE25021, GSE108869, GSE165895, ENCSR000EFJ, ENCSR000BTU, GSE115602, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, GSE94872, ENCSR895JMI, GSE98367, ENCSR193NSH, GSE206145, GSE85526, ENCSR000BTQ, GSE129526, ENCSR153HNT, GSE68388, GSE126990
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Cell type: HuCC-T1, RPE, HMEC, Fibroblast, HEKn, Ishikawa, HeLa-S3, IMR-90, K-562, HFFc6, Monocytes, SK-N-SH, Macrophage, MCF-7, Hela-Kyoto, HCT-116, A-549, HUVEC, HCAEC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 16% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.789
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
56% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 77%,
"7_Enh": 14%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, PGR, SMARCA2, E2F7, SOX2, MEIS2, FOXA1, PBX2, ATF3, NFIC, CHD7, PRDM1, SMARCE1, CDX2, JMJD1C, ELF1, TEAD1, KLF6, NFE2L2, ZNF217, ESR1, HNF1B, MLL, JUN, TCF12, BAF155, EP300, SOX9, GATA6, DPF2, SOX4, E2F1, SMC1, TEAD4, PDX1, TFAP2C, NANOG, CDK9-HEXIM1, CTBP1, ZBTB48, STAT1, SRF, MLLT3, ERG, HOXC5, MYC, SMARCA4, ARID1B, RAD21, LHX2, GRHL3, RXRA, NKX2-1, GABPA, STAT3, NKX3-1, RCOR1, VDR, ZNF750, ESRRA, NR3C1, CEBPB, CREB1, GRHL2, EBF3, TRPS1, ZHX2, SPI1, EHF, IRF1, HDAC2, GATA2, GATAD2B, FLI1, ZNF766, MRTFB, NCOA2, RUNX1, SMC1A, ZBTB24, CBX1, EZH2phosphoT487, NKX2-2, SIN3A, SMAD3, SMARCC1, MEF2A, ZXDC, CREBBP, RUNX2, CDK6, GATA4, GR, PBX4, ARNT, NFIB, DAXX, PBX3, FOXM1, FOS, CDK8, MED1, PIAS1, NR1H2, STAT5A, USF1, NIPBL, SP1, MAFK, HNF4A, REST, ARID1A, ATF7, CTBP2, PHIP, MBD2, SMC3, STAG2, STAG1, PPARG, FOXA2, CBX3, PAF1, SS18, MEF2C, HOXB13, KDM1A, YY1, RELA, NEUROD1, JUNB, HIF1A, OTX2, GATA3, TAL1, MAX, NRIP1, KLF4, NR2F2, TCF7L2, KDM5B, TP53, NFKB1, ELF3, BHLHE40, AR, EGLN2, HSF1, BRD4, JUND, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): .
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 21
- Related genes and loops