- Basic information
- CohesinDB ID: CDBP00413598
- Locus: chr21-15824259-15827480
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE93080, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, Ramos, GM19238, HeLa, TC-71, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 69% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.244
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
58% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"5_TxWk": 55%,
"4_Tx": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, IRF1, NOTCH1, MYB, CDK7, CHD7, ARNT, HNF1B, BRD4, NKX2-1, FOXA1, GABPA, CDK9, SUPT5H, TBX21, LMO1
- Target gene symbol (double-evidenced CRMs): HSPA13,USP25,NRIP1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 440
- Number of somatic mutations (non-coding): 11
- Related genes and loops
- Related gene:
ENSG00000155304,
ENSG00000180530,
ENSG00000155313,
- Related loop:
chr21:14250000-14275000~~chr21:15825000-15850000,
chr21:14375000-14400000~~chr21:15800000-15825000,
chr21:14375000-14400000~~chr21:15825000-15850000,
chr21:15050000-15075000~~chr21:15825000-15850000,
chr21:15500000-15525000~~chr21:15825000-15850000,
chr21:15520229-15521680~~chr21:15825383-15827192,
chr21:15520337-15521600~~chr21:15825285-15827222,
chr21:15520438-15521729~~chr21:15825379-15827213,
chr21:15575000-15600000~~chr21:15800000-15825000,
chr21:15591163-15593391~~chr21:15825411-15827711,
chr21:15591857-15593440~~chr21:15825433-15827080,
chr21:15600000-15625000~~chr21:15800000-15825000,
chr21:15600000-15625000~~chr21:15825000-15850000,
chr21:15625000-15650000~~chr21:15825000-15850000,
chr21:15678908-15680651~~chr21:15825379-15827213,
chr21:15678925-15680577~~chr21:15825423-15827778,
chr21:15679142-15680653~~chr21:15824955-15827171,
chr21:15681831-15683975~~chr21:15825446-15827214,
chr21:15725000-15750000~~chr21:15825000-15850000,
chr21:15728981-15731357~~chr21:15825379-15827213,
chr21:15729091-15731386~~chr21:15825686-15827611,
chr21:15729281-15731390~~chr21:15825659-15827066,
chr21:15729455-15730632~~chr21:15825625-15827005,
chr21:15729526-15731390~~chr21:15825285-15827222,